Protein Alignment Ppp3cc and CanA1

DIOPT Version :9

• Sequence 1: NP_001291920.1
• Gene: Ppp3cc / 19057
• MGIID: 107162
• Length: 522
• Species: Mus musculus
• Sequence 2: NP_001247378.2
• Gene: CanA1 / 43670
• FlyBaseID: FBgn0010015
• Length: 622
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 355/505 - (70%)
• Similarity: 414/505 - (81%)
• Gaps: 35/505 - (6%)

Mouse    10 TTERVIKAVPFPPTRRLTLKEVFEN---GKPKMDLLKNHLVKEGRVEEEVALKIINDGAAILKQE 71
            |.||::..||.|||.:||:.||:::   |||..|.|:.|.:.|||:||.|||:||.:|||:|::|
  Fly    51 TRERMVDDVPLPPTHKLTMSEVYDDPKTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLREE 115

Mouse    72 KTMIEVEAPITVCGDVHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINH 136
            |.||:||||||||||:|||||||:|||||||.|:.||||||||||||||||||||||||||||.:
  Fly   116 KNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITY 180

Mouse   137 PKTLFLLRGNHECRHLTEYFTFKQECRIKYSEMVYDACMHTFDCLPLAALLNQQFLCVHGGMSPE 201
            |.||.|||||||||||||||||||||.|||||.:|||||..||||||||||||||||:|||:|||
  Fly   181 PTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPE 245

Mouse   202 ITCLEDIRKLDRFSEPPAFGPVCDLLWSDPLEDYGSEKTLEHYTHNTVRGCSYFFSYPAVCEFLQ 266
            |..|:||:.|:||.||||:||:|||||||||||:|:|||.|.::||:||||||||||.|.|||||
  Fly   246 IFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQ 310

Mouse   267 NNSLLSIIRAHEAQDAGYRMYRKNQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 331
            .|:||||:|||||||||||||||||.|||||||||||||||||||||||||||||||||||||||
  Fly   311 KNNLLSIVRAHEAQDAGYRMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 375

Mouse   332 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDEEM-----NVTDEE------------ 379
            |||||||||||||||||||||||||||||||||||||||:|:     :..:||
  Fly   376 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDDELVAGPDDELEEELRKKIVLVPANA 440

Mouse   380 -----DHYISSCPKGATTGRKEVIKNKIRAIGKMARVFTVLREESENVLTLKGLTPTGTLPLGVL 439
                 ::...|.|...:..|||:|:|||||||||:|||::||||||:||.||||||||.||:|.|
  Fly   441 SNNNNNNNTPSKPASMSALRKEIIRNKIRAIGKMSRVFSILREESESVLQLKGLTPTGALPVGAL 505

Mouse   440 SGGKQTIETAKQEAAEEREAIRGFTIAHRIRSFEEARGLDRINERMPPRK 489
            |||:.::          :||::|.|.:..|.||.||:|||.:|||||||:
  Fly   506 SGGRDSL----------KEALQGLTASSHIHSFAEAKGLDAVNERMPPRR 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppp3cc	NP_001291920.1	MPP_PP2B	37..341	CDD:277361	247/303 (82%)
		Catalytic. /evidence=ECO:0000305	52..343		242/290 (83%)
		PP2Ac	54..325	CDD:197547	223/270 (83%)
		SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:P16298	344..366		21/21 (100%)
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P16298	394..408		11/13 (85%)
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	409..416		3/6 (50%)
		Autoinhibitory domain. /evidence=ECO:0000250|UniProtKB:P16298	467..489		14/21 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..522		7/9 (78%)
CanA1	NP_001247378.2	MPP_PP2B	81..385	CDD:277361	247/303 (82%)
		PP2Ac	98..369	CDD:197547	223/270 (83%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832385
Domainoid	1	1.000	89	1.000	Domainoid score	I7810
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	1	1.010	-	-		D194337at33208
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	O	PTHR45673
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X576
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.720