Protein Alignment Ppp3ca and Pp2B-14D

DIOPT Version :9

• Sequence 1: NP_032939.1
• Gene: Ppp3ca / 19055
• MGIID: 107164
• Length: 521
• Species: Mus musculus
• Sequence 2: NP_001245715.1
• Gene: Pp2B-14D / 32624
• FlyBaseID: FBgn0011826
• Length: 570
• Species: Drosophila melanogaster
• Alignment Length: 494
• Identity: 396/494 - (80%)
• Similarity: 438/494 - (88%)
• Gaps: 16/494 - (3%)

Mouse    11 LSTTDRVVKAVPFPPSHRLTAKEVFD-NDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQ 74
            ::|.:|||.:|||||||:||..|||| ..|||..::||.|.:.|||:||:.||:||.:||::|||
  Fly    76 VNTKERVVDSVPFPPSHKLTLAEVFDQRTGKPNHELLKQHFILEGRIEEAPALKIIQDGAALLRQ 140

Mouse    75 EKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKIL 139
            ||.::||:|||||||||||||:|||||||||||||:|:||||||||||||||||||||||:|||.
  Fly   141 EKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKIT 205

Mouse   140 YPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSP 204
            ||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   206 YPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSP 270

Mouse   205 EINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCDFL 269
            ||:.|:|||:|||||||||:|||||:|||||||||||||..:.:|||:||||||||||.|.||||
  Fly   271 EIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFL 335

Mouse   270 QHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQF 334
            |:||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   336 QNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQF 400

Mouse   335 NCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSE--EDGFDGATAAARKEVIR 397
            |||||||||||||||||||||||||||||||||||||||||||.:|  |:......||.||||||
  Fly   401 NCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMTEESEEPLSDDEAALRKEVIR 465

Mouse   398 NKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFS 462
            ||||||||||||||||||||||||.||||||||.||.|.||||||:|::          |::|||
  Fly   466 NKIRAIGKMARVFSVLREESESVLQLKGLTPTGALPLGALSGGKQSLKN----------AMQGFS 520

Mouse   463 PQHKITSFEEAKGLDRINERMPPRRDAMPS---DANLNS 498
            |.||||||.||||||.:|||||||||..|:   |.|.:|
  Fly   521 PNHKITSFAEAKGLDAVNERMPPRRDQPPTPSEDPNQHS 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppp3ca	NP_032939.1	MPP_PP2B	41..345	CDD:277361	261/303 (86%)
		Catalytic. /evidence=ECO:0000305	56..340		249/283 (88%)
		SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000250|UniProtKB:Q08209	327..336		8/8 (100%)
		Calcineurin B binding. /evidence=ECO:0000269|PubMed:26794871	341..369		27/27 (100%)
		Calmodulin-binding. /evidence=ECO:0000269|PubMed:26794871	392..406		13/13 (100%)
		Autoinhibitory segment. /evidence=ECO:0000269|PubMed:26794871	407..414		6/6 (100%)
		Autoinhibitory domain. /evidence=ECO:0000269|PubMed:26794871	465..487		18/21 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..521		16/27 (59%)
Pp2B-14D	NP_001245715.1	MPP_PP2B	107..411	CDD:277361	261/303 (86%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	396	1.000	Domainoid score	I753
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55497
Inparanoid	1	1.050	817	1.000	Inparanoid score	I472
Isobase	1	0.950	-	0.740582	Normalized mean entropy	S271
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	1	1.000	-	-		mtm8855
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	O	PTHR45673
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R954
SonicParanoid	1	1.000	-	-		X576
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810