DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppib and cyp33

DIOPT Version :9

Sequence 1:	NP_035279.2	Gene:	Ppib / 19035	MGIID:	97750	Length:	216	Species:	Mus musculus
Sequence 2:	NP_523773.1	Gene:	cyp33 / 36984	FlyBaseID:	FBgn0028382	Length:	300	Species:	Drosophila melanogaster

Alignment Length:	178	Identity:	94/178 - (52%)
Similarity:	121/178 - (67%)	Gaps:	4/178 - (2%)

- Green bases have known domain annotations that are detailed below.

Mouse    29 GPSVANDKKKGPKVTVKVYFDLQIGDESVGRVVFGLFGKTVPKTVDNFVALATGEKGFGYKNSKF 93
            ||:|.   :|..|...:|:||::||....||:|..|....||||.:||..|.|.|:|:|||...|
  Fly   127 GPAVI---EKAEKRNPQVFFDIRIGGNDAGRIVMLLRADVVPKTAENFRQLCTHEQGYGYKGCSF 188

Mouse    94 HRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVK 158
            ||||.:||.||||||..:|||||||||::|.||||.|||...|.:||||:|.:||||||||.|.|
  Fly   189 HRVIPEFMCQGGDFTNNNGTGGKSIYGKKFNDENFNLKHNSFGTLSMANSGANTNGSQFFICTTK 253

Mouse   159 TSWLDGKHVVFGKVLEGMDVVRKVESTKTDSRDKPLKDVIIVDSGKIE 206
            |.|||.||||||.|:.|.:||||:|...:.| ..|.:.::|...|:::
  Fly   254 TDWLDNKHVVFGHVISGAEVVRKMERCGSKS-GTPSQKIVIYSCGELK 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppib	NP_035279.2	cyclophilin_ABH_like	45..203	CDD:238907	88/157 (56%)
Ppib	NP_035279.2	Prevents secretion from ER. /evidence=ECO:0000250	213..216
cyp33	NP_523773.1	RRM_PPIE	8..80	CDD:240793
cyp33	NP_523773.1	cyclophilin_ABH_like	139..297	CDD:238907	88/158 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810