DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S1PR3 and ador-1

DIOPT Version :9

Sequence 1:	NP_001382777.1	Gene:	S1PR3 / 1903	HGNCID:	3167	Length:	378	Species:	Homo sapiens
Sequence 2:	NP_001040809.1	Gene:	ador-1 / 174890	WormBaseID:	WBGene00011878	Length:	362	Species:	Caenorhabditis elegans

Alignment Length:	381	Identity:	88/381 - (23%)
Similarity:	168/381 - (44%)	Gaps:	85/381 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    41 LTTVLFLVICSFIV-----LENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSG 100
            :.|:|:..|...::     ..||:||....::.........:|.:|||.|.|||   .:.|.::.
Worm     1 MDTLLWYAIAELLLSIHISFSNLLVLWVYVRSKHVRTVTNTYIFSLALTDFLAG---ALGIPLTV 62

Human   101 KKTFSLSPTVWFLREGSMFVAL------GASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIG 159
            ....:..|..::   |.:||.|      ..||..:|||||::::|:.......:::|.|...|:.
Worm    63 VSVMTRKPRTFY---GCLFVHLILCILCTISTFHMLAIAIDKYVTICCRDRIFSSRRKRAIFLLT 124

Human   160 MCWLIAFTLGALP---ILGWN-----CLHNLPDCS-TILPLYSKKYIAFCISIFTAILVT--IVI 213
            ..|::...:..||   :.|:.     .:.|...|. |::..|  :|:.:.|...|.:..|  ||:
Worm   125 TSWILGLLVAILPLFNVFGFAETQSLFIENGEMCHFTMVVDY--RYLVYVIFFSTILAPTAIIVL 187

Human   214 LYARIYFLVKSSSRKV---ANHNNSERSMA----LLRTVVIVVSVFIACWSPLFILFLIDV---A 268
            ||:.||..:::..::|   ...:..||.||    |:|.::|:|..:..||.||:|:..||.   .
Worm   188 LYSSIYSRIRTEEKQVKCLLRQSERERRMAGRRKLIRILLILVVSYGICWYPLYIINTIDYFWPE 252

Human   269 CRVQACPILFKAQWFIVLAVLNSAMNPVIYTLAS---KEMRRAFFRL-----VC---NCLVRGRG 322
            ..:.:..:     |.::::.::.|:||:||....   |:..||||.:     .|   :|.:..|
Worm   253 FSINSLTL-----WTVIMSHMSCALNPLIYAYGMPGFKKALRAFFNIQTDNNTCANYSCYMSFR- 311

Human   323 ARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPH----------TAPSSCIMDKN 368
                             |::|....|..|: .:|:          :||:..::|::
Worm   312 -----------------STANQKQRSISVR-GMPYETSLAAIRKISAPTPTMLDRH 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S1PR3	NP_001382777.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..358		5/40 (13%)
ador-1	NP_001040809.1	7tm_GPCRs	5..288	CDD:391938	72/295 (24%)
		TM helix 1	6..32	CDD:341315	5/25 (20%)
		TM helix 2	39..66	CDD:341315	9/29 (31%)
		TM helix 3	76..106	CDD:341315	11/29 (38%)
		TM helix 4	119..137	CDD:341315	2/17 (12%)
		TM helix 5	166..196	CDD:341315	11/31 (35%)
		TM helix 6	217..247	CDD:341315	10/29 (34%)
		TM helix 7	256..281	CDD:341315	6/29 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910