DRSC/TRiP Functional Genomics Resources

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Protein Alignment LPAR1 and Rh6

DIOPT Version :9

Sequence 1:NP_001338326.1 Gene:LPAR1 / 1902 HGNCID:3166 Length:364 Species:Homo sapiens
Sequence 2:NP_524368.5 Gene:Rh6 / 41889 FlyBaseID:FBgn0019940 Length:369 Species:Drosophila melanogaster


Alignment Length:352 Identity:66/352 - (18%)
Similarity:135/352 - (38%) Gaps:69/352 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    31 AFFYNRSGKHLAT-----------------EWNTVSKLVMG-LGITVCI---FIMLANLLVMVAI 74
            :|.|.|.|::|:.                 :|..:..:..| :|..:.|   ..:..|.:||...
  Fly     8 SFAYMRDGRNLSLAESVPAEIMHMVDPYWYQWPPLEPMWFGIIGFVIAILGTMSLAGNFIVMYIF 72

Human    75 YVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDT-----SL-- 132
            ..::....|....:.|||.:||.    ..:.||  .|........||::...|.:.     ||  
  Fly    73 TSSKGLRTPSNMFVVNLAFSDFM----MMFTMF--PPVVLNGFYGTWIMGPFLCELYGMFGSLFG 131

Human   133 TASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSN 197
            ..|:.::..||.:|:..:.:......::....|:.::|:||:......:|..|||......|.:.
  Fly   132 CVSIWSMTLIAYDRYCVIVKGMARKPLTATAAVLRLMVVWTICGAWALMPLFGWNRYVPEGNMTA 196

Human   198 MAPLY------SDSYLVFWAIFNLVTFVVMVVL-YAHIFGYV-------RQRTMRM---SRHSSG 245
            ....|      :.||::.::::..:|.::.::. |.||...|       |::..:|   |..:|.
  Fly   197 CGTDYFAKDWWNRSYIIVYSLWVYLTPLLTIIFSYWHIMKAVAAHEKAMREQAKKMNVASLRNSE 261

Human   246 PRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFL---------LLAE 301
            ..:::...:.|.|..:..:..:...|||..::....:         :|...|         :.|:
  Fly   262 ADKSKAIEIKLAKVALTTISLWFFAWTPYTIINYAGI---------FESMHLSPLSTICGSVFAK 317

Human   302 FNSAMNPIIYSYRDKEMSATFRQILCC 328
            .|:..|||:|.....:.....|:.:.|
  Fly   318 ANAVCNPIVYGLSHPKYKQVLREKMPC 344

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LPAR1NP_001338326.1 7tmA_LPAR1_Edg2 50..322 CDD:341348 58/308 (19%)
TM helix 1 52..76 CDD:341348 6/27 (22%)
TM helix 2 85..106 CDD:341348 5/20 (25%)
TM helix 3 122..144 CDD:341348 5/28 (18%)
Lysophosphatidic acid binding. /evidence=ECO:0000305|PubMed:26091040 124..129 1/4 (25%)
TM helix 4 166..182 CDD:341348 3/15 (20%)
TM helix 5 203..226 CDD:341348 3/23 (13%)
TM helix 6 257..279 CDD:341348 4/21 (19%)
TM helix 7 290..315 CDD:341348 8/33 (24%)
Rh6NP_524368.5 7tmA_photoreceptors_insect 48..338 CDD:320207 58/304 (19%)
TM helix 1 50..74 CDD:320207 5/23 (22%)
TM helix 2 83..105 CDD:320207 8/27 (30%)
TM helix 3 121..143 CDD:320207 4/21 (19%)
TM helix 4 165..181 CDD:320207 3/15 (20%)
TM helix 5 209..232 CDD:320207 3/22 (14%)
TM helix 6 273..295 CDD:320207 4/21 (19%)
TM helix 7 306..331 CDD:320207 6/24 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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