DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LPAR1 and TkR86C

DIOPT Version :9

Sequence 1:	NP_001338326.1	Gene:	LPAR1 / 1902	HGNCID:	3166	Length:	364	Species:	Homo sapiens
Sequence 2:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	410	Identity:	94/410 - (22%)
Similarity:	174/410 - (42%)	Gaps:	79/410 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIML 65
            :.::.:|| :.::....::||.:.|..|.: |........|..|..|:..::.||    .:|:.:
  Fly    40 VVSLLSSI-IDNRDNLESINEAKDFLTECL-FPSPTRPYELPWEQKTIWAIIFGL----MMFVAI 98

Human    66 A-NLLVMVAIYVNRRFHFPIYYLMANLAAADFFAG----LAYFYLMFNTGPNTRRLTVSTW---- 121
            | |.:|:..:..:|.......|.:.||:.||....    :..|..|.|          |.|
  Fly    99 AGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLN----------SDWPFGS 153

Human   122 ---LLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPS 183
               .:...:.:.:::.||..|:||:.:|:|.:.. .|..|.|.|:|.:::|:||.::.|:.| |.
  Fly   154 IYCTINNFVANVTVSTSVFTLVAISFDRYIAIVH-PLKRRTSRRKVRIILVLIWALSCVLSA-PC 216

Human   184 VGWNCICDIEN--------CSNMAP--LYSDSYLVFWAIFNLVTFV--------VMVVLYAHIFG 230
            :.::.|.....        |..|.|  .|..|...:  .:||:..|        ||::.|: :.|
  Fly   217 LLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADY--AYNLIILVLTYGIPMIVMLICYS-LMG 278

Human   231 YVRQRTMRMSRHSSGPRRNRDTMMSLLKTV---VIVLGAFIICWTPGLVLLLLDVCCPQCDVLAY 292
            .|...:..:..::.   |..::|.|..|.|   :.::..|.|||.|   ..|..:.....:.:|.
  Fly   279 RVLWGSRSIGENTD---RQMESMKSKRKVVRMFIAIVSIFAICWLP---YHLFFIYAYHNNQVAS 337

Human   293 EKF-------FLLLAEFNSAMNPIIYSYRDKEMSATFRQILCC-------QRSENPTGPTEGSDR 343
            .|:       |..||..|:.:||:||.:.:|.....|::|:||       .|.::|.......:
  Fly   338 TKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPKSRLTNKN- 401

Human   344 SASSLNHTILAGVHSNDHSV 363
              ||..||  .|.::..||:
  Fly   402 --SSNRHT--RGGYTVAHSL 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LPAR1	NP_001338326.1	7tmA_LPAR1_Edg2	50..322	CDD:341348	71/311 (23%)
		TM helix 1	52..76	CDD:341348	6/24 (25%)
		TM helix 2	85..106	CDD:341348	6/24 (25%)
		TM helix 3	122..144	CDD:341348	5/21 (24%)
		Lysophosphatidic acid binding. /evidence=ECO:0000305\|PubMed:26091040	124..129		0/4 (0%)
		TM helix 4	166..182	CDD:341348	5/15 (33%)
		TM helix 5	203..226	CDD:341348	6/30 (20%)
		TM helix 6	257..279	CDD:341348	7/24 (29%)
		TM helix 7	290..315	CDD:341348	10/31 (32%)
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	71/308 (23%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	64/283 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910