DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pparg and Hr96

DIOPT Version :9

Sequence 1:	NP_035276.2	Gene:	Pparg / 19016	MGIID:	97747	Length:	505	Species:	Mus musculus
Sequence 2:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster

Alignment Length:	380	Identity:	99/380 - (26%)
Similarity:	143/380 - (37%)	Gaps:	104/380 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse   130 PSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRC--DLNCRIHKKSRNKCQY 192
            |.|      |.||||||.|:::....||.||.||||....|..: .|  :.||.|...:|..||.
  Fly     4 PKN------CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQF-TCPFNQNCDITVVTRRFCQK 61

Mouse   193 CRFQKCLAVGMSHNAIRFGRMPQAEKEKL--------------LAEISSD-IDQLNPESADLRAL 242
            ||.:|||.:||....|      .:|::||              |.|..:| .|....|..|.:|.
  Fly    62 CRLRKCLDIGMKSENI------MSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAP 120

Mouse   243 A-------KHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKI---------- 290
            |       .| |.....|.....|.:.|.........||..  .:|.|.|..:||
  Fly   121 ADSSSSNLDH-YSGSQDSQSCGSADSGANGCSGRQASSPGT--QVNPLQMTAEKIVDQIVSDPDR 182

Mouse   291 KFKHITPLQEQSKEVAIRIFQ---GCQFRSVEAVQEITEY----AKNIPGFINLDLNDQVTLLKY 348
            ..:.|..|....|| ||.:.:   ..|..::..|..:.:|    .|.|..|:|...|......|:
  Fly   183 ASQAINRLMRTQKE-AISVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKF 246

Mouse   349 ------GVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSL-RKPFGDFMEPKFEFAVKFNALE 406
                  || |||    :.:::....::         ||:::| ..|     |...:...||
  Fly   247 MSSPTDGV-EII----SKIVDSPADVV---------EFMQNLMHSP-----EDAIDIMNKF---- 288

Mouse   407 LDDSDLAIFIAVIILSG----------DRPGLLN----VKPIEDIQ--DNLLQAL 445
            ::....|:.|...||||          ||..||:    |||....:  |.::|::
  Fly   289 MNTPAEALRILNRILSGGGANAAQQTADRKPLLDKEPAVKPAAPAERADTVIQSM 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pparg	NP_035276.2	PPARgamma_N	31..108	CDD:289354
		NR_DBD_Ppar	138..221	CDD:143523	33/84 (39%)
		Interaction with FAM120B. /evidence=ECO:0000269\|PubMed:17595322	205..280		19/96 (20%)
		NR_LBD_PPAR	237..504	CDD:132730	57/256 (22%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P37231	495..503
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	36/105 (34%)
		NR_LBD	462..>573	CDD:299703
		NR_LBD_F1	523..702	CDD:132727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847966
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.800