Protein Alignment ABCA1 and snu

DIOPT Version :10

• Sequence 1: NP_005493.2
• Gene: ABCA1 / 19
• HGNCID: 29
• Length: 2261
• Species: Homo sapiens
• Sequence 2: NP_651628.1
• Gene: snu / 43391
• FlyBaseID: FBgn0039594
• Length: 808
• Species: Drosophila melanogaster
• Alignment Length: 1010
• Identity: 202/1010 - (20%)
• Similarity: 353/1010 - (34%)
• Gaps: 305/1010 - (30%)

Human   892 PTHLKLGVSIQNLVKVY--RDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTS 954
            |.:.:..||:::..|.|  :......::.|.:...:|.|...||.:|.||||.:|.:.|.....:
  Fly    67 PRNTQAAVSVRHAFKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDA 131

Human   955 GTAYILGKDIRSEMSTI-RQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALD 1018
            |..::||....:..|.: .:.:|..||...|:...:::|.:.::..:.|:..|.:...::.:...
  Fly   132 GEIFVLGGKPGTRGSGVPGKRVGYMPQEIALYGEFSIQETMMYFGWIFGMDTKEILERLQFLLNF 196

Human  1019 VGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQG-- 1081
            :.|||.|...|  .||||.||::|.|:|.:...:::||||||.||||..|:.||..|:...:.
  Fly   197 LDLPSEKRLVK--NLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQ 259

Human  1082 RTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSS 1146
            :|:|::||:::||. ....|.::..|.|....|...|     ...|..:..::|...||..::..
  Fly   260 KTVIITTHYIEEAR-QAHTIGLMRSGHLLAEESPSVL-----LSIYKCISLEEVFLKLSRIQSQK 318

Human  1147 STVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYE 1211
            ..|:::...:::|..:...|...|..|
  Fly   319 GDVTHVNFSNNISLHAMAFGSKMDKPS-------------------------------------- 345

Human  1212 AAKEGAFVEL-FHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAF 1275
            :::||..|.| ||:..:.|.:   .|.|...|..:|.:               ...|:|||...
  Fly   346 SSQEGGVVGLNFHQSKEVLIN---DSNGSIYTLNQEPY---------------SPPPSRRNNNP- 391

Human  1276 GDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLLIA 1340
            .|::||...::.                    |..:..||..:            |||.|.:|..
  Fly   392 NDEESCQDCYSN--------------------LCKITSKGKIR------------ALLTKNMLRM 424

Human  1341 RRS---RKGFFAQIVLPAVFVCIALVFSLIVPPFGKYP-SLELQPWMYNEQYTFVSNDAPEDTGT 1401
            .|:   ....||..|:..:..|:|:         |:.| .|.|.          :.|....||
  Fly   425 WRNVGVMLFIFALPVMQVILFCLAI---------GRDPQGLNLA----------IVNGEMNDT-- 468

Human  1402 LELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQCS 1466
                             :..|...:..|.                  |:|         ..|:..
  Fly   469 -----------------VRENCYWEDGCH------------------FKN---------LGCRYL 489

Human  1467 SDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQII--AKSLKNKIWVNE 1529
            |                                    :::..:||||.:.:  ||....|
  Fly   490 S------------------------------------HLNTSVVKTYYEDLDDAKEAVRK----- 513

Human  1530 FRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWF 1594
                |.:.|     |:..|:...||   ......|.:||. |..::|           :.||||.
  Fly   514 ----GTAWG-----AVYISENFTDA---FIARANLGRDSD-DETIDS-----------SEVKVWL 554

Human  1595 NNKGWHAISSFLN-----VINNAILRANLQKGENPSHYGI-TAFNHPLNLTKQQLSEVALMTTSV 1653
            :... ..|...||     ...:..:....|.|.||....: ..|..|:..|         |..|.
  Fly   555 DMSN-QQIGVMLNRDIQLAFRDFAMGLLGQCGSNPKLGDVPIQFRDPIYGT---------MNPSF 609

Human  1654 ------DVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWD---MCN 1709
                  .|:::|....|::...::.::    ||........:::||.|.....|:.:..   ||.
  Fly   610 TDFVAPGVILTIVFFLAVALTSSALII----ERTEGLLDRSWVAGVSPFEILFSHVITQFVVMCG 670

Human  1710 YVVPATLVII-IFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSV 1773
               ..|||:| :.:.|   ...::.:|..:.:|.||.|      |....|.|.|.|...:...::
  Fly   671 ---QTTLVLIFMLVVF---GVTNNGDLFWVIVLTLLQG------MCGMCFGFLISSVCELERNAI 723

Human  1774 NLFIGINGSVATFVLELFTDN---KLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERF 1835
            .|.:|      :|...|....   .:..:..:|:.:.|..| ..|....:..:..:..| .||..
  Fly   724 QLALG------SFYPTLLLSGVIWPIEGMPVVLRYISLCLP-LTLATSSLRSILTRGWA-ILESD 780

Human  1836 GENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLI 1870
            ....:||.||| :||            |.::|:|:
  Fly   781 VYIGYVSTLSW-IVG------------FLVLTLLV 802

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA1	NP_005493.2	rim_protein	6..2236	CDD:130324	202/1010 (20%)
		Annulus domain 1. /evidence=ECO:0000305|PubMed:35974019	69..80
		Annulus domain 2. /evidence=ECO:0000305|PubMed:35974019	368..379
		Gateway domain. /evidence=ECO:0000305|PubMed:35974019	564..594
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1283..1312		1/28 (4%)
snu	NP_651628.1	CcmA	74..311	CDD:440746	68/244 (28%)
		YadH	609..807	CDD:440604	47/231 (20%)