Protein Alignment ABCA1 and CG31213

DIOPT Version :10

• Sequence 1: NP_005493.2
• Gene: ABCA1 / 19
• HGNCID: 29
• Length: 2261
• Species: Homo sapiens
• Sequence 2: NP_732473.2
• Gene: CG31213 / 42382
• FlyBaseID: FBgn0051213
• Length: 1809
• Species: Drosophila melanogaster
• Alignment Length: 2061
• Identity: 481/2061 - (23%)
• Similarity: 839/2061 - (40%)
• Gaps: 551/2061 - (26%)

Human   437 RMLLDSRDNDHFWEQ-QLDGLDWTAQDIVAFLAK----------------HPEDVQ--------S 476
            |:||        |:. :|...:|....::.||:.                .|.|::        |
  Fly    12 RLLL--------WKDIKLQLTNWVELVMIIFLSALMPIFFSIGTKVAKSIFPPDIEMEKSPGPKS 68

Human   477 SNGSVYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLIN--KSMELLDE---------- 529
            .|.|::.  :.:...|..|              ||.:.|::..|:  ||:|:.|.
  Fly    69 VNTSLFV--DLYFTPNNGI--------------LEQLITQLANISEFKSVEVFDTNSELYLQLMI 117

Human   530 RKFWAGIVFTGITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFA 594
            .:...||.|..........|..:...|.|.: :::|                  :|.:|...||.
  Fly   118 NRNAIGIAFPSEWYDIKSCPEVLNLTIFMPL-SIKR------------------KDFKYFESGFL 163

Human   595 YLQDVVEQAIIRVL-TGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKG 658
            .||:.:.:..|... .|..|...|.|...|||.||.:.:.. .:::|.....:::......|.|.
  Fly   164 LLQERISKIFIFFKNAGNGKIPRVLMNHFPYPSYVPNHYAE-SAKAMTYMTLISFFLPCITIAKY 227

Human   659 IVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLS 723
            :|.|||...|..:..||..|||.|.:|:..|::.||:...:::.|..:|.:..:|....:.....
  Fly   228 VVAEKERHQKAVLTAMGFSNSIHWLAWYTKSMLLLLLCLLIMISIFSIGLIYEFSSLVCLMTIFL 292

Human   724 VFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFASLLSPVAFG 788
            |:....:|..|.||:.|||:..|.....::||:..||:::..|....|  ..:..||:....|..
  Fly   293 VYIHSLVLFAFFISSFFSRSLSAVVATILMYFSTALPFLIVGAENSSV--AAQTAASIGLNSALF 355

Human   789 FGCEYFALFEEQGIGVQW---DNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTW-------YIE 843
            :..:..|:.|.|.:|.||   ||...|     |:.|:....|::..:     ::|       |||
  Fly   356 YILDSVAVMEMQSVGAQWYTIDNTASS-----GYKLSIVGYMLIMIS-----ISWIELLICLYIE 410

Human   844 AVFPGQYGIPRPWYFPCTKSYW----FGE-------------ESDEKSHPGSNQKRISEICMEEE 891
            ||..|::.:|:||.:|..:.||    :|.             ::.|.:.|.::..|...|.:::.
  Fly   411 AVRTGEFEVPQPWSYPFQRRYWCPLRYGSSVFHQGALLPLAGKNSEGNLPAAHPTRQPIIYLDDR 475

Human   892 PTH--------LKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTG 948
            ...        .|:|:.:::|.|.:  |.:..|..|..|.||.:||:.:||.|:||||.:.:|.|
  Fly   476 TQENFQRVNISKKIGIEVRSLSKTF--GFRNVVKDLFFNVYENEITALVGHKGSGKTTIIMMLCG 538

Human   949 LFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEME 1013
            :..||:||..|.|.||.:|....:.:||:||||:|:|..::..:||:|::|:||.::.....|..
  Fly   539 ILQPTTGTVLINGYDIVTEAKVAKSSLGICPQHSVIFKGMSARDHIYFFSRVKGYNKTEAMMESN 603

Human  1014 QMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY 1078
            .....:||..|: |....:||.|.||:||:|.|...||||::.|||::|:||..|..:...|.|.
  Fly   604 IYISKLGLVDSQ-KWDAMRLSPGNQRRLSLACALCAGSKVILCDEPSSGLDPIGRHELMRFLQKE 667

Human  1079 RQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCR 1143
            :.||||:::|..::|.::|.|||||::.|::.|.|:..:||....|.|.|            ||:
  Fly   668 KHGRTILMTTQQLEEGEILADRIAIMNDGQILCYGTLGYLKQLPFTSYTL------------SCQ 720

Human  1144 NSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVL 1208
                                   :..:.::|.||       :|:|.:::........|.:::|.|
  Fly   721 -----------------------MAPNSKADNLT-------DLVRLYMTTTTSPVFHGVDVSYKL 755

Human  1209 PYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRR 1273
            |  .::...|.|.|.::::....|.:.|:|:|::||:.|:|.:....| .:....|..|...::.
  Fly   756 P--RSQIDRFPEFFQQLEENKKSLNVVSFGVSDSTLDGIYLSLDYGQG-SSRLRGGADPGVNDKV 817

Human  1274 AFG---DKQSCLRPFTEDDAAD-----------PNDSDID------------PESRETDLLSGMD 1312
            .||   ||  .:|  |:|.|.:           ||::.::            |..||
  Fly   818 EFGVQTDK--AIR--TKDRANNSLVRYQHQVDPPNETILNTKTPINPIEIWRPIDRE-------- 870

Human  1313 GKGSYQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPF------ 1371
             |||...:             |:.:.|   .:|.:.|...|  :|:.|     ||:|.|
  Fly   871 -KGSCMAQ-------------WQAMFI---KKKNYTASRAL--IFILI-----LIIPLFYYIIVL 911

Human  1372 ------------GKYP--SLELQPWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGN 1422
                        .|.|  .|.|..:.|::....           ||:...|.|..|
  Fly   912 GTAASEKCAHRTDKQPVLPLSLDYYSYDDMIIL-----------LEVDKQLYKSEG--------- 956

Human  1423 PIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPP 1487
                                :..:.|.:         .||...|.|.|...|...||
  Fly   957 --------------------EAYVQLVK---------EPATVESVDSIFSHLLKAPP-------- 984

Human  1488 QRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVN 1552
                                        ||.:.:|.|          :..|.|...|
  Fly   985 ----------------------------IIRRDIKRK----------YVCGASFNNA-------- 1003

Human  1553 DAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGW-HAISSFLNVINNAI--- 1613
                                               :.:..|||:..: |:....||::.||:
  Fly  1004 -----------------------------------STITAWFNSDAFEHSAPIALNLVYNALGKA 1033

Human  1614 ---------------------------LRANLQKGENP-----SHYGITAFNHPL---------- 1636
                                       :|...::..:|     |.|.|..::..:
  Fly  1034 VFEDQDFSILVNRGDLHDFIWLNNASSMRRRYKRQNDPDYTDYSDYEIQEYDVVVKPNSSSTSGQ 1098

Human  1637 ---------NLTKQQLSEVALMTTSVD------------VLVSICVIFAMSFVPASFVVFLIQER 1680
                     |:...|:|.:...:|..:            ::::..:...:|.    |.:|:.:||
  Fly  1099 HNKSNPGDDNIITVQMSIIEAASTLYNEKGKRKQLFGTLIIITAYIALCLSI----FSIFVTKER 1159

Human  1681 VSKAKHLQFISGVKPVIYWLSNFVWDMCNYVV---PATLVIIIFICFQQKSYVSSTNLPVLALLL 1742
            |...|..|.|.||....:|.::||.|...|.:   ..|:.|..|..:.|           :.::|
  Fly  1160 VEHFKMQQEIYGVTLFYFWSTHFVGDFLIYAIYMGALTIAIYHFTIWYQ-----------VVVML 1213

Human  1743 LLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATF--VLELFTDNKLNNINDILKS 1805
            ||.|::..|.:|..|.:|.:|:.|:..:.::.:..|  |.:.:|  :|.|.||     :|  ..:
  Fly  1214 LLIGFACLPFVYLCSLLFSLPNIAFAGIFAILVMTG--GMLFSFMYMLTLITD-----VN--FTT 1269

Human  1806 VFLIFPHFCLGRGLIDMVK-----NQAMADALE----RFGENRFVSPLSWDLVGRNLFAMAVEGV 1861
            ||.|.|.:....||...:.     |:.:...:|    :||..........:.....::.:.|..:
  Fly  1270 VFAILPMYVGTFGLFKCLAWREYCNREVLPPIEELDCKFGNCNVFCACKPERTWMEVWLLMVHCL 1334

Human  1862 VFFLITVL------IQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGG-------QNDILE 1913
            |:|:....      |.|||  :|:..| ::...|::...|..|.:|:    |       ::..:.
  Fly  1335 VWFIFLWFSNFGYEIGYRF--KPKLSN-RIWHNNEKHIRVLDEERRV----GLIPKYEHEDYPII 1392

Human  1914 IKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSIL 1978
            :.::||.|.| .|.||..:...|.||:.|||||..||||:|.|:|:.|:|:::.|:.::..:|:.
  Fly  1393 VDQVTKNYCR-AKNAVQLVSFAIRPGDTFGLLGAQGAGKTSIFQMIAGETSMSHGNIYVRGHSLR 1456

Human  1979 SNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAG 2043
            .:.:.....:|:|||.|...:.||||:.:....||.|||:..:..|.|....:.......::...
  Fly  1457 EHRNAAKMEVGFCPQGDNAPKYLTGRQLLRIHCLLHGVPKDHIKAVSEQMAIEFNFKDQLDRPIH 1521

Human  2044 NYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECE 2108
            .||||.||||:.|:|:..| .|:.||:....:|...:||:|....:|.:.||.|:||:.||||..
  Fly  1522 TYSGGKKRKLNIALAIDSG-SVLCLDDTNGSVDHATQRFIWRKLEAVKRSGRPVLLTTQSMEEAN 1585

Human  2109 ALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGL------AFPGSV 2167
            |:|:|:|.:|.|....:||:|.:::...:  |||:|:..:..|.|..:.|..|      .||.:.
  Fly  1586 AVCSRVAFLVAGEMMFIGSLQQVRSEVSN--TIVIRLRVNPSDGKLKRRFQQLIADMAELFPLAT 1648

Human  2168 LKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKD 2232
            |.|.....|.|.:..::::||.:|..:.:.:....:||||::|.:||::: ....|: :|.:|.|
  Fly  1649 LHEALETCLIYHININVTTLANLFYQMEKIRNEGLLEDYSITQVSLDEIY-RILNDE-EDPNLVD 1711

Human  2233 L-SLHKNQTVVDV----------------AVLTSFLQDEKVKESYV 2261
            | |.|.::.:.|:                .|....:|.||||...|
  Fly  1712 LDSTHNSEVLEDIRDTTRDTTRGTTRDTNLVSDEGIQKEKVKRKKV 1757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA1	NP_005493.2	rim_protein	6..2236	CDD:130324	472/2018 (23%)
		Annulus domain 1. /evidence=ECO:0000305|PubMed:35974019	69..80
		Annulus domain 2. /evidence=ECO:0000305|PubMed:35974019	368..379
		Gateway domain. /evidence=ECO:0000305|PubMed:35974019	564..594		4/29 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1283..1312		9/51 (18%)
CG31213	NP_732473.2	rim_protein	<118..1698	CDD:130324	443/1868 (24%)