Protein Alignment ABCA1 and CG42816

DIOPT Version :10

• Sequence 1: NP_005493.2
• Gene: ABCA1 / 19
• HGNCID: 29
• Length: 2261
• Species: Homo sapiens
• Sequence 2: NP_730301.3
• Gene: CG42816 / 39977
• FlyBaseID: FBgn0261998
• Length: 1459
• Species: Drosophila melanogaster
• Alignment Length: 1726
• Identity: 461/1726 - (26%)
• Similarity: 773/1726 - (44%)
• Gaps: 381/1726 - (22%)

Human   592 GFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVD----DIFLRVMSRSMP----LFMTLAW 648
            ||..:|..:.|..|:.......||   ...:.:|...|    .||....|.::.    :.:.:..
  Fly    14 GFLAVQQALSQVHIKHKCKEFNKT---QGDIKFPPIKDLPSPPIFKSDNSSTLQDVGIMIIVIII 75

Human   649 IYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLG------ 707
            .:.|..:.|.||.|||.:||.|:.:||:.:.:.|.:|:|.:.|..|:.:.::.:..||.
  Fly    76 FFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITLFWKLVLPNSEI 140

Human   708 NLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVG 772
            :.:|::..|:....|.|.:..||...||:|:|.|.....:....:.....|||:::..:.....|
  Fly   141 SFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPFLILHSKGCSEG 205

Human   773 FTLKIFASL-----LSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDT 832
              |.:|.||     |..:..|     ..::|:.|.|:||.||||:.......::...:.:|:..:
  Fly   206 --LNVFLSLFLLSGLQVLVVG-----ICMWEDYGEGLQWGNLFETSWPGGTLSVGYILLVMILAS 263

Human   833 FLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGS--------------NQKRI 883
            ||..::..|:|.:.||.||:|:||:||||:..     |.|...|.|              :::|.
  Fly   264 FLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCC-----STESLLPYSRLFNRIFGIYSAAPDEERP 323

Human   884 SEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTG 948
            ....:|.:|.....||.|:.|.|.:  |....|..::.:.:|||||..:|||||||||.:|:|.|
  Fly   324 DLQLIEPDPVDKIAGVQIRGLSKTF--GKMEVVKNVSFDMFEGQITVLMGHNGAGKTTLISMLAG 386

Human   949 LFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEME 1013
            ...||||||.|.|.|||.|....::.:|:|||.||||..|:...||..::||:||....||:|::
  Fly   387 FISPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSEVQ 451

Human  1014 QMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY 1078
            .....:.|...| :.....||||.||:||||.:..||.||:|.|||:.|:||.:||.:|.|:|:.
  Fly   452 NYLKKLNLQEKK-RLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWRLILEA 515

Human  1079 RQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCR 1143
            ::|.||:|:||.:|:.:|||||:.|||.|:|.|:||..|||.|:..            |.|.:|.
  Fly   516 KEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQVDA------------SCLITCE 568

Human  1144 NSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVL 1208
                    .:|.                      .|:..:::||.:||...:.....|.::.|.|
  Fly   569 --------ARKR----------------------CDLEKLTSLISRHVGTIQPFSIKGRDVCYKL 603

Human  1209 PYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRR 1273
            |...:|  .|..||.:::.:::.||:..:.:|..:|||||:....|. :::..|.|.
  Fly   604 PLSKSK--YFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGAED-LNSRQSGGA-------- 657

Human  1274 AFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLL 1338
                           :..|.:|.|.|.|:..      .||......|.|:       |::.|:::
  Fly   658 ---------------EKRDDDDRDDDEENEV------QDGNVRSCKKQWR-------AMMTKKVM 694

Human  1339 IARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGTLE 1403
             |....|.:|..::|..:...|..:.....|.....|             ||..:|...|..|:.
  Fly   695 -ALYDNKVYFLLLLLTPIVYYITTLMMATKPHHSGRP-------------TFNISDYGVDKFTIL 745

Human  1404 LLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQCSSD 1468
            |                                 :.||.::..:
  Fly   746 L---------------------------------SVPVSKSYTE--------------------- 756

Human  1469 KIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYG 1533
                                  :..||.:..         |:|..:::|..|.:.|.:|::
  Fly   757 ----------------------ERRADSIAS---------LIKGKLKLIVVSEQIKDYVDD---- 786

Human  1534 GFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKG 1598
                   ..::....:|:|        .:.:|.| :.||         |||            .|
  Fly   787 -------KWKSREGRREIN--------FVSMAID-TGDR---------TGL------------IG 814

Human  1599 W-------HAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVL 1656
            |       ||....||::.||:    .|:...|. ..|...:.|..|.|:   |..|::.:.|:
  Fly   815 WVGPRHYVHAAPMILNLVYNAL----AQELIGPK-ISIEVTSVPFTLRKK---EDFLISNNGDI- 870

Human  1657 VSICVIFAMSFVPASFVVF---LIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVI 1718
                .|:.:.:|..:.::|   :||||||..|.||.:||::.:.||||:..:||          :
  Fly   871 ----PIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAFDM----------V 921

Human  1719 IIFICFQQKSYVSSTNLPVLALLLLLYGWS-------------ITPLMYPASFVFKIPSTAY--- 1767
            :.||.             ||||||.|||::             :..|:: ..|:..:.|..:
  Fly   922 VFFIL-------------VLALLLPLYGYAPWYLLLCVLFFTGLAGLIF-IYFLISMLSATFLAV 972

Human  1768 -VVLTSV---NLFIGINGSVATFVLELFTDNKLNNINDILKSVFLI---FPHFCLGRGLIDMVKN 1825
             ::|.||   :|.:.|.|::|.....::....:.|::.::.....|   |.:..|....|...:|
  Fly   973 SMILLSVIIGSLILMILGALALIFKMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQN 1037

Human  1826 QAMADALE---------RFGENR--FVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPR 1879
            ....:...         .|.|.|  .|:|::|.    ::..|....::.||:.:..:|...:..|
  Fly  1038 PLSENLTSDEMYCINPLAFLEPRCVCVNPMTWP----DMLVMLGTAIILFLLIMFFEYGSCVWYR 1098

Human  1880 -----PVNAKLSPLNDEDEDVRRERQRI----LDGGGQNDILEIKELTKIYRRKRKPAVDRICVG 1935
                 |.::|.|   .||..|.||.::|    .|..|.. .|.:..::|.|...:. ||:.|...
  Fly  1099 CKGCCPYSSKGS---IEDPKVSREAEKIRAMDADQIGTR-ALVVNGVSKKYGCDQL-AVNNISFA 1158

Human  1936 IPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITEL 2000
            :.|..|.||||.|||||::||||:.|:.::.:|:.:::..|:....::..:.:|||||.|:..|.
  Fly  1159 LKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEF 1223

Human  2001 LTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPV 2065
            ||||:.::.|.|:.|.|.|::.|..|....:.|..|:.:|....||||.|||::.|:| .|...:
  Fly  1224 LTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSL 1287

Human  2066 VFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQH 2130
            :.||||:.|:||.:||.:|.....|.::|::|:||||:|:|..|||::..|:|:|....:|||||
  Fly  1288 ICLDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQH 1352

Human  2131 LKNRFGDGYTIVVRIAGSNPD-----LKPVQDFFGLAFPGSVLKEKHR--NMLQYQLPSSLSSLA 2188
            :||:...|.|:.: :....||     |..::|...:.:|.:.||||:.  ..|.:|: |..:|.:
  Fly  1353 VKNKIAKGMTLKL-VVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQI-SKDTSWS 1415

Human  2189 RIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQ 2224
            .||..:..::...|:||||:||.:|:..|...|:::
  Fly  1416 EIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEER 1451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA1	NP_005493.2	rim_protein	6..2236	CDD:130324	461/1726 (27%)
		Annulus domain 1. /evidence=ECO:0000305|PubMed:35974019	69..80
		Annulus domain 2. /evidence=ECO:0000305|PubMed:35974019	368..379
		Gateway domain. /evidence=ECO:0000305|PubMed:35974019	564..594		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1283..1312		5/28 (18%)
CG42816	NP_730301.3	rim_protein	<81..1451	CDD:130324	448/1654 (27%)