Protein Alignment ABCA1 and Eato

DIOPT Version :10

• Sequence 1: NP_005493.2
• Gene: ABCA1 / 19
• HGNCID: 29
• Length: 2261
• Species: Homo sapiens
• Sequence 2: NP_001036360.1
• Gene: Eato / 34783
• FlyBaseID: FBgn0028539
• Length: 1597
• Species: Drosophila melanogaster
• Alignment Length: 1739
• Identity: 451/1739 - (25%)
• Similarity: 748/1739 - (43%)
• Gaps: 424/1739 - (24%)

Human   584 EDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAW 648
            :|..|:..||..||.::::..:: .....|...|.:..||     :...:.:.|..:..|.||..
  Fly   170 DDDDYIRSGFLSLQHILDKQYMK-YQELGKDFEVVVSSMP-----NMEVISMDSHRLTYFGTLCS 228

Human   649 IYSVAVIIKGIVY----EKEARLKETMRI---MGLDNSILWFSWFISSLIPLLVSAGLLVVILKL 706
            |....|::...|.    ||:..|||.:.:   |...|.:.:|      ||..:....|::.:|.:
  Fly   229 ILFNVVLLSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFF------LIRFVCYTLLMIFVLVV 287

Human   707 GNLLPYSDPSVVFVFLSVFAVVTILQ----CFLISTLFSRANLAAACGGIIYFTLYLPYVLCV-- 765
            ..|.. :..|:.|.:::|..::.||.    .:|||..| .:...|..||:.  .|.:||....
  Fly   288 AYLYK-ALGSICFAYVAVLFLLYILSTMSYAYLISICF-HSVFYAKIGGLA--MLIIPYAFSFVR 348

Human   766 AWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVS---- 826
            :|...:.|.      ..|...|..|.:.|..|..:....::..:       |.|.:..|.|
  Fly   349 SWATSLAFV------CFSTNTFLEGLDIFQTFSNKRKNREFGAV-------DVFRVIKSNSSTMF 400

Human   827 ----MMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYF---PCTKSYWFGEESDEKSHP-GSNQKRI 883
                :::|.:|||.::..|:..||||..|:.||.:|   |  |:|...:.::..:.| |::...|
  Fly   401 SVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDP--KTYMKRQRNEYTTTPRGTHAIII 463

Human   884 SEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTG 948
            :|:|.:.:.:.....:|                |.|.:.....:||..||||||||||.|:::.|
  Fly   464 TELCKKFQTSKRDTLIS----------------DNLNMTINNKEITVLLGHNGAGKTTMMNMIMG 512

Human   949 LFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEME 1013
            |.|..||...:..:   .::::.|..:|.||||:|....:|..:|:.|:|:|:|......:...:
  Fly   513 LVPKDSGKIIVCSE---RDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWAD 574

Human  1014 QMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY 1078
            :....:|| |.|.......|||||:|:||:.:|..|.:|:||||||::|:|..|||.:|::||..
  Fly   575 EKLKKLGL-SDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNL 638

Human  1079 RQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCR 1143
            |:.:.::::||:|:||:||||.|.|:::|||..:||.|.||.:.|.||.|.|
  Fly   639 RKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKL------------- 690

Human  1144 NSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVL 1208
                                        |.:..|.....|..:|...|..||::..:...:...|
  Fly   691 ----------------------------EINDFTSREVEIMEIIHHFVPTARVLNVVNPTVYICL 727

Human  1209 PYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVA-EESGVDAETSDGTLPARRNR 1272
            ||  |.:..|.::.:.::....:|||.:..:::|:||::||:.| |:..||  |.||:    ||
  Fly   728 PY--AYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQVD--TPDGS----RN- 783

Human  1273 RAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRL 1337
                                           :..||:.                       :|||
  Fly   784 -------------------------------DAPLLAH-----------------------YKRL 794

Human  1338 LIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWM--YNEQYTFVSNDAPEDTG 1400
            . .....:|.|                               |.||  :.:::||:||   |...
  Fly   795 Q-DHPPHRGLF-------------------------------QLWMAVFYKKWTFISN---EWLY 824

Human  1401 TLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQC 1465
            ||.:|            |     ||.. |..|      |.:....|.|.:|     :...|.
  Fly   825 TLIML------------C-----IPFV-CVFG------AILVMHAMSLVEN-----EEALPL--- 857

Human  1466 SSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEF 1530
               |:.:|      |:|.:           .:.:.||.:..          :.:.|:.:|.:|
  Fly   858 ---KLSQM------GSGVI-----------YVHNPTGHHAH----------LEQQLRQQIELN-- 890

Human  1531 RYGGFSLGV-SNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSL---------GRFMTGLD 1585
                   |: :.|..|..|.:|.:      :.|.|.:|:.|| ||..:         ||   |..
  Fly   891 -------GITAKTMHLRGSNDVKN------ESLDLQRDNLAD-FLEQVIGIIDMYGGGR---GTS 938

Human  1586 TKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMT 1650
            ....::::::...:|:....:|::::|:|:....:.|..:.| :.......:::..:|...|
  Fly   939 DTPTIEIFYSGNRYHSSVELINLVDSAMLKLGRPESEIDTTY-VPIRRFVSDISPSRLEYYA--- 999

Human  1651 TSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPAT 1715
                |:|.|.:.|.|.:    |:....:|..:..|.||.:|   ...||.::|.:||
  Fly  1000 ----VIVPIGMFFFMFY----FISLPFREYANGFKQLQTMS---RFTYWFAHFTFDM-------- 1045

Human  1716 LVIIIFIC---FQQKSYV------SSTNLPVLALLLLLYGWSITPLMYPASFVFKIPST--AYVV 1769
             :|:||:|   |..:|.:      ::..|.|:.|.:..||.|..|::|.....||..||  .|::
  Fly  1046 -LILIFVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYALGNNFKSISTISTYLL 1109

Human  1770 LTSVNLFIG--INGSVATFV---------LELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMV 1823
            |..:...|.  |..|.|..:         |....|..||:...|:...|:...|..|.:|||
  Fly  1110 LMLIVSAIAPLITSSNAAAMKLHETKIAFLCFLPDFNLNHQFRIINENFITRRHPALIKGLI--- 1171

Human  1824 KNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIR----------- 1877
                        .::.|.:           :|.||..:|....|:::::::..|
  Fly  1172 ------------SQDTFFA-----------YATAVGVMVMAFFTIVLEHKYLRRRIHDGIWEWAF 1213

Human  1878 -PRPVNA----KLSPLNDEDEDVRRERQRILD--GGGQND-ILEIKELTKIYRRKRKPAVDRICV 1934
             .:..|:    ..:|:::.| |..||.:|:.|  ....|| .|.:..|.|.|..|.  |||.:..
  Fly  1214 QRKKYNSTGTLPSTPISEID-DCAREEKRVTDLIKDPLNDHSLIVHNLRKRYGDKL--AVDGVSF 1275

Human  1935 GIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITE 1999
            ....||||||||||||||:|||:|:..:..:..|...:....|..:..:..:..|||||:||:.:
  Fly  1276 AAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNK 1340

Human  2000 LLTGREHVEFFALLRGVPEKEVG-------KVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAM 2057
            .:|..:.:.:.|||||:..:...       .|..| :.|:.|.||.:....:||||.||||..||
  Fly  1341 FMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYW-LEKMHLTKYQKVQVRHYSGGTKRKLLAAM 1404

Human  2058 ALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRF 2122
            |:||.|.:|.|||||||:||.:|||||.|......:.|:||||||||:|||.||.|:|||.:|:|
  Fly  1405 AMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKF 1469

Human  2123 RCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGL---AFPGSVLKEKHRNMLQYQLPSSL 2184
            :||.::..||..  .|:||.:::.........|....|.   .|||..|:|.|...|.|.:.:..
  Fly  1470 KCLNNICALKRL--SGFTIKLKMKADTETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQE 1532

Human  2185 SSL--ARIFSILSQ---SKKRLHIEDYSVSQTTLDQVFVNF---AKDQS 2225
            |.:  :.:|.|..:   .:....:.||||::.||:.:|:.|   ||.||
  Fly  1533 SVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREAKSQS 1581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA1	NP_005493.2	rim_protein	6..2236	CDD:130324	451/1739 (26%)
		Annulus domain 1. /evidence=ECO:0000305|PubMed:35974019	69..80
		Annulus domain 2. /evidence=ECO:0000305|PubMed:35974019	368..379
		Gateway domain. /evidence=ECO:0000305|PubMed:35974019	564..594		3/9 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1283..1312		2/28 (7%)
Eato	NP_001036360.1	rim_protein	<169..1591	CDD:130324	451/1739 (26%)