DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA1 and Eato

DIOPT Version :9

Sequence 1:NP_005493.2 Gene:ABCA1 / 19 HGNCID:29 Length:2261 Species:Homo sapiens
Sequence 2:NP_001036360.1 Gene:Eato / 34783 FlyBaseID:FBgn0028539 Length:1597 Species:Drosophila melanogaster


Alignment Length:1739 Identity:451/1739 - (25%)
Similarity:748/1739 - (43%) Gaps:424/1739 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   584 EDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAW 648
            :|..|:..||..||.::::..:: .....|...|.:..||     :...:.:.|..:..|.||..
  Fly   170 DDDDYIRSGFLSLQHILDKQYMK-YQELGKDFEVVVSSMP-----NMEVISMDSHRLTYFGTLCS 228

Human   649 IYSVAVIIKGIVY----EKEARLKETMRI---MGLDNSILWFSWFISSLIPLLVSAGLLVVILKL 706
            |....|::...|.    ||:..|||.:.:   |...|.:.:|      ||..:....|::.:|.:
  Fly   229 ILFNVVLLSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFF------LIRFVCYTLLMIFVLVV 287

Human   707 GNLLPYSDPSVVFVFLSVFAVVTILQ----CFLISTLFSRANLAAACGGIIYFTLYLPYVLCV-- 765
            ..|.. :..|:.|.:::|..::.||.    .:|||..| .:...|..||:.  .|.:||....  
  Fly   288 AYLYK-ALGSICFAYVAVLFLLYILSTMSYAYLISICF-HSVFYAKIGGLA--MLIIPYAFSFVR 348

Human   766 AWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVS---- 826
            :|...:.|.      ..|...|..|.:.|..|..:....::..:       |.|.:..|.|    
  Fly   349 SWATSLAFV------CFSTNTFLEGLDIFQTFSNKRKNREFGAV-------DVFRVIKSNSSTMF 400

Human   827 ----MMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYF---PCTKSYWFGEESDEKSHP-GSNQKRI 883
                :::|.:|||.::..|:..||||..|:.||.:|   |  |:|...:.::..:.| |::...|
  Fly   401 SVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDP--KTYMKRQRNEYTTTPRGTHAIII 463

Human   884 SEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTG 948
            :|:|.:.:.:.....:|                |.|.:.....:||..||||||||||.|:::.|
  Fly   464 TELCKKFQTSKRDTLIS----------------DNLNMTINNKEITVLLGHNGAGKTTMMNMIMG 512

Human   949 LFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEME 1013
            |.|..||...:..:   .::::.|..:|.||||:|....:|..:|:.|:|:|:|......:...:
  Fly   513 LVPKDSGKIIVCSE---RDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWAD 574

Human  1014 QMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY 1078
            :....:|| |.|.......|||||:|:||:.:|..|.:|:||||||::|:|..|||.:|::||..
  Fly   575 EKLKKLGL-SDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNL 638

Human  1079 RQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCR 1143
            |:.:.::::||:|:||:||||.|.|:::|||..:||.|.||.:.|.||.|.|             
  Fly   639 RKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKL------------- 690

Human  1144 NSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVL 1208
                                        |.:..|.....|..:|...|..||::..:...:...|
  Fly   691 ----------------------------EINDFTSREVEIMEIIHHFVPTARVLNVVNPTVYICL 727

Human  1209 PYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVA-EESGVDAETSDGTLPARRNR 1272
            ||  |.:..|.::.:.::....:|||.:..:::|:||::||:.| |:..||  |.||:    || 
  Fly   728 PY--AYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQVD--TPDGS----RN- 783

Human  1273 RAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRL 1337
                                           :..||:.                       :|||
  Fly   784 -------------------------------DAPLLAH-----------------------YKRL 794

Human  1338 LIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWM--YNEQYTFVSNDAPEDTG 1400
            . .....:|.|                               |.||  :.:::||:||   |...
  Fly   795 Q-DHPPHRGLF-------------------------------QLWMAVFYKKWTFISN---EWLY 824

Human  1401 TLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQC 1465
            ||.:|            |     ||.. |..|      |.:....|.|.:|     :...|.   
  Fly   825 TLIML------------C-----IPFV-CVFG------AILVMHAMSLVEN-----EEALPL--- 857

Human  1466 SSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEF 1530
               |:.:|      |:|.:           .:.:.||.:..          :.:.|:.:|.:|  
  Fly   858 ---KLSQM------GSGVI-----------YVHNPTGHHAH----------LEQQLRQQIELN-- 890

Human  1531 RYGGFSLGV-SNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSL---------GRFMTGLD 1585
                   |: :.|..|..|.:|.:      :.|.|.:|:.|| ||..:         ||   |..
  Fly   891 -------GITAKTMHLRGSNDVKN------ESLDLQRDNLAD-FLEQVIGIIDMYGGGR---GTS 938

Human  1586 TKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMT 1650
            ....::::::...:|:....:|::::|:|:....:.|..:.| :.......:::..:|...|   
  Fly   939 DTPTIEIFYSGNRYHSSVELINLVDSAMLKLGRPESEIDTTY-VPIRRFVSDISPSRLEYYA--- 999

Human  1651 TSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPAT 1715
                |:|.|.:.|.|.:    |:....:|..:..|.||.:|   ...||.::|.:||        
  Fly  1000 ----VIVPIGMFFFMFY----FISLPFREYANGFKQLQTMS---RFTYWFAHFTFDM-------- 1045

Human  1716 LVIIIFIC---FQQKSYV------SSTNLPVLALLLLLYGWSITPLMYPASFVFKIPST--AYVV 1769
             :|:||:|   |..:|.:      ::..|.|:.|.:..||.|..|::|.....||..||  .|::
  Fly  1046 -LILIFVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYALGNNFKSISTISTYLL 1109

Human  1770 LTSVNLFIG--INGSVATFV---------LELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMV 1823
            |..:...|.  |..|.|..:         |....|..||:...|:...|:...|..|.:|||   
  Fly  1110 LMLIVSAIAPLITSSNAAAMKLHETKIAFLCFLPDFNLNHQFRIINENFITRRHPALIKGLI--- 1171

Human  1824 KNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIR----------- 1877
                        .::.|.:           :|.||..:|....|:::::::..|           
  Fly  1172 ------------SQDTFFA-----------YATAVGVMVMAFFTIVLEHKYLRRRIHDGIWEWAF 1213

Human  1878 -PRPVNA----KLSPLNDEDEDVRRERQRILD--GGGQND-ILEIKELTKIYRRKRKPAVDRICV 1934
             .:..|:    ..:|:::.| |..||.:|:.|  ....|| .|.:..|.|.|..|.  |||.:..
  Fly  1214 QRKKYNSTGTLPSTPISEID-DCAREEKRVTDLIKDPLNDHSLIVHNLRKRYGDKL--AVDGVSF 1275

Human  1935 GIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITE 1999
            ....||||||||||||||:|||:|:..:..:..|...:....|..:..:..:..|||||:||:.:
  Fly  1276 AAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNK 1340

Human  2000 LLTGREHVEFFALLRGVPEKEVG-------KVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAM 2057
            .:|..:.:.:.|||||:..:...       .|..| :.|:.|.||.:....:||||.||||..||
  Fly  1341 FMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYW-LEKMHLTKYQKVQVRHYSGGTKRKLLAAM 1404

Human  2058 ALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRF 2122
            |:||.|.:|.|||||||:||.:|||||.|......:.|:||||||||:|||.||.|:|||.:|:|
  Fly  1405 AMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKF 1469

Human  2123 RCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGL---AFPGSVLKEKHRNMLQYQLPSSL 2184
            :||.::..||..  .|:||.:::.........|....|.   .|||..|:|.|...|.|.:.:..
  Fly  1470 KCLNNICALKRL--SGFTIKLKMKADTETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQE 1532

Human  2185 SSL--ARIFSILSQ---SKKRLHIEDYSVSQTTLDQVFVNF---AKDQS 2225
            |.:  :.:|.|..:   .:....:.||||::.||:.:|:.|   ||.||
  Fly  1533 SVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREAKSQS 1581

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCA1NP_005493.2 rim_protein 6..2236 CDD:130324 451/1739 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1283..1312 2/28 (7%)
EatoNP_001036360.1 ABC2_membrane_3 <209..347 CDD:289468 35/147 (24%)
CcmA 460..767 CDD:224054 110/369 (30%)
ABC_subfamily_A 461..679 CDD:213230 84/237 (35%)
ABC2_membrane_3 <937..1117 CDD:289468 44/203 (22%)
ABC_subfamily_A 1255..1479 CDD:213230 99/226 (44%)
drrA 1262..1573 CDD:130256 122/315 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148381
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.660

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