Protein Alignment ABCA1 and Abca3

DIOPT Version :10

• Sequence 1: NP_005493.2
• Gene: ABCA1 / 19
• HGNCID: 29
• Length: 2261
• Species: Homo sapiens
• Sequence 2: NP_608445.2
• Gene: Abca3 / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Alignment Length: 1933
• Identity: 628/1933 - (32%)
• Similarity: 977/1933 - (50%)
• Gaps: 362/1933 - (18%)

Human   410 HDLEGMWEELSPKIWTFMENSQEMDLVRMLLDSRDND--HFWEQQLDGLDWTAQD---------I 463
            |..:.:.|.:.|.|::.:     :.|||.|:|:....  ::.||.|..|:.....         :
  Fly    24 HKWQMVIELVLPAIFSLL-----LVLVRTLVDTEQKGVRYYNEQNLTDLNLLQHSLHRSSYLGKL 83

Human   464 VAFLAKHPEDVQSSNG-SVYTWREAFNETNQAIRTI----------SRFMECVNLNKLEPIATEV 517
            :|.:|  |...:.:.| |.:.:...::..|..::.:          ::..|..|..:||
  Fly    84 IALIA--PNRRRKNGGFSKFEFILCYSPVNPVLKKLVEEAWQSLGKNKICESENATQLE------ 140

Human   518 WLINKSMELLDERKFWAGIVFTGITPGSIE---LPHHVKYKIR---------MDIDNVERTNKIK 570
                  ::.:.:..| ||:.|........|   ||:...:.:|         :.|.|...|.::.
  Fly   141 ------LDTVSKNAF-AGVQFDDAWANLTENDPLPNDFHFALRFPAELRTATIAIANTWLTMRLF 198

Human   571 DGYWDPGPRADPFED----MRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDI 631
            ......|||.:..:|    ..|:..||..||..:..|.:|..:|.:....|.|::.|:|.|:.|.
  Fly   199 PTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSMAYLRQKSGEQDLPNVVMKRYPFPAYIFDP 263

Human   632 FLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVS 696
            .|..||..|.|.:.|::||....|.|.|..|||.:|||.|:||||.|.:.|.:||:.|.|.|.:|
  Fly   264 LLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFIMLTIS 328

Human   697 AGLLVVILKLG-----NLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFT 756
            |.|:.:::|:.     .:|.:::.:.:..||.::.|.:|..||:::|.||||:.|||..|:|:|.
  Fly   329 AILIAILVKINWSEDVAVLTHANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFI 393

Human   757 LYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNL 821
            .|:||...:...|.:..:.|:..||:|..|.|||.:....||..|.|:||.|.|.....:|...|
  Fly   394 AYIPYSFTINSYDDLSLSSKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSVDDTLTL 458

Human   822 TTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEE--SDEKSHPGSNQKRIS 884
            ...:.|||....:|.::..|:|.|.||.:|:||||.||.|:.:|.||.  :..:..|..:.::..
  Fly   459 GAVMIMMLVSCVIYMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTGVEDIPNGHVEQRD 523

Human   885 EICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGL 949
            ....|.||....:|:.:::|.|  |.|.|:.|.||::|.:|.:||..|||||||||||:|:|||:
  Fly   524 PKAFETEPEGKHIGLQMRHLKK--RFGNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGM 586

Human   950 FPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQ 1014
            ||||||||.|.|.|||:.:...|.:||:|||||||||.::|..||.|::|:|||..|.|:.|:.:
  Fly   587 FPPTSGTAIINGSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAK 651

Human  1015 MALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYR 1079
            ....:.| ..|....:|:|||||:|||||..|..|.:|||:.|||::|:||.:||.:|:||.:.:
  Fly   652 YLKMIEL-EDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEK 715

Human  1080 QGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRN 1144
            .|||::|:||.|||||||||||||:..|:|.|.|:|.|||.|.|:||.|..||:|
  Fly   716 VGRTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRD---------- 770

Human  1145 SSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLP 1209
                                         |..|.:|:|   |:.|::...:...|||.||:|.||
  Fly   771 -----------------------------DCETNEVTA---LLNKYIPGLKPECDIGAELSYQLP 803

Human  1210 YEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRA 1274
            ..|:.:  |.|:|.:::::..:|.::.||:..|::||:|:||..|              :.|...
  Fly   804 DSASAK--FEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAE--------------KDNTGN 852

Human  1275 FGDKQSCLR---PFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKR 1336
            ..|:...:.   .|..:|         |.||.::|   |:..:....::|.:|...|:.|:|.|:
  Fly   853 IKDQHEIMNGGSGFRGED---------DNESVQSD---GIFSENRRLLQGLQLLSNQWKAMLLKK 905

Human  1337 LLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGT 1401
            .|...|::.....|.::|..||.:.:   ||:...|.:.  ||:|.                  |
  Fly   906 FLYTWRNKLLLLIQNIMPVFFVVVTI---LIIKTQGTFQ--ELKPI------------------T 947

Human  1402 LELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDL--FQNGNWTMQNPSPACQ 1464
            :.|                                |..|:..|::|.  .|||
  Fly   948 ISL--------------------------------TQYPLAVTVLDRSNVQNG------------ 968

Human  1465 CSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNE 1529
                                                ||     |.:....:.:|:|
  Fly   969 ------------------------------------TG-----YEIANKYEDLARS--------- 983

Human  1530 FRYG-GFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVW 1593
              || .:.|.::.||..      .|.|..:.|.:::..:|   |:|      :....|::.:..|
  Fly   984 --YGSNYGLELTGTQGF------EDYILDLGKTIQVRINS---RYL------VAATITESKITAW 1031

Human  1594 FNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVS 1658
            .||:..|.....:|:::|||  |:...|   |...|...|.||..|...|........::...::
  Fly  1032 LNNQALHTAPLTVNMVHNAI--ADKLFG---SSVKIQVTNAPLPYTTSTLLSQLSTGNNLGTQLA 1091

Human  1659 ICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFIC 1723
            ..:.|.|.||.:.:::|||:||.|:||.|||:.|||...:|||.|:.|..:|:|.|.:|:|..:|
  Fly  1092 SNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVITIVC 1156

Human  1724 FQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVL 1788
            ||:....:...|....|||||:|:::.|.:|..|..|:.|:|.:..::.||:|.|:...:...|:
  Fly  1157 FQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVM 1221

Human  1789 --ELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPL------- 1844
              ||| |.|  :..|||..:|.|||||.|...|..:..|.|..:|..:.|.   :.|:
  Fly  1222 SSELF-DTK--DTADILGWIFRIFPHFSLAMSLNKVYTNTATRNACAKAGA---LPPILLCELVP 1280

Human  1845 ---------SWDLVG--RNLFAMAVEGVVFFLITVLIQYR------FFIR-------PRPVNAKL 1885
                     :|:..|  .....|||.|||||||.:::::|      |.||       |.|...:|
  Fly  1281 QCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIVLEFRLINELMFKIRQLISKPPPPPTEGQL 1345

Human  1886 SPLNDEDEDVRRERQRILDGGGQNDI----LEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLG 1946
                  |:||..||:|||. ...|::    |.:..:||.|.:..  ||:::.:.:...|||||||
  Fly  1346 ------DDDVANERERILQ-MSSNELATKNLVLDRVTKYYGQFM--AVNQVSLCVQEVECFGLLG 1401

Human  1947 VNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFA 2011
            ||||||::||||:|||..::.|.|::...|:.||::.:::.:||||||||:.:.|||||.:..|.
  Fly  1402 VNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFDALLDDLTGREVLRIFC 1466

Human  2012 LLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMD 2076
            :||||.|..:.::.|...:..|.:|:.:|....||||||||||||:|:||.|.|::|||||||||
  Fly  1467 MLRGVQESRIRQLSEDLAKSFGFMKHIDKQTHAYSGGNKRKLSTAIAVIGSPSVIYLDEPTTGMD 1531

Human  2077 PKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTI 2141
            |.|||.|||....:...|:|:||||||||||||||||:||||||.|:|:||.|||||:|..|..:
  Fly  1532 PAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLAIMVNGEFKCIGSTQHLKNKFSKGLIL 1596

Human  2142 VV------------RIAGS---NP------------DLKPVQDFFGLAFPGSVLKEKHRNMLQYQ 2179
            .:            |::|.   ||            |:..|::|....:|.|:|:|:::.:|.:.
  Fly  1597 KIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDIDAVKEFVETEYPNSILQEEYQGILTFY 1661

Human  2180 LPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDD 2227
            :|.:....:|||.::..::.:|::||||||||||:::|:.|||.|.:|
  Fly  1662 IPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTLEEIFLEFAKYQRED 1709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA1	NP_005493.2	rim_protein	6..2236	CDD:130324	628/1933 (32%)
		Annulus domain 1. /evidence=ECO:0000305|PubMed:35974019	69..80
		Annulus domain 2. /evidence=ECO:0000305|PubMed:35974019	368..379
		Gateway domain. /evidence=ECO:0000305|PubMed:35974019	564..594		7/33 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1283..1312		7/31 (23%)
Abca3	NP_608445.2	rim_protein	<137..1708	CDD:130324	606/1810 (33%)