Protein Alignment ABCA1 and CG43672

DIOPT Version :10

• Sequence 1: NP_005493.2
• Gene: ABCA1 / 19
• HGNCID: 29
• Length: 2261
• Species: Homo sapiens
• Sequence 2: NP_788912.3
• Gene: CG43672 / 318910
• FlyBaseID: FBgn0263747
• Length: 1690
• Species: Drosophila melanogaster
• Alignment Length: 2018
• Identity: 399/2018 - (19%)
• Similarity: 723/2018 - (35%)
• Gaps: 600/2018 - (29%)

Human   436 VRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQS------SNGSVYTWREAF-NETNQ 493
            :|...||...|:....:.:.|:::...::..:.:....:.|      :|..:...|.|| ..:|.
  Fly    44 IRSSSDSNMRDYSIRAEAELLEFSWSSLIGKIQERRAKMASKQRNFTTNVFIPDIRVAFAPNSNA 108

Human   494 AIRTI------------SRFMECVNLNKLE-PIATEVWLINKSMELLDERKFWAGIV--FTGITP 543
            |:|.:            .:.::..|.|.:. ..|:|.:|.:.....:||.......|  |..|.|
  Fly   109 ALRRLMGDALGKLSMSEDKIVDFENCNDMRIHAASEHYLASVCFRNVDESLNGLPTVLNFAIIMP 173

Human   544 GSIELPHHVKYK------------IRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYL 596
            ..:.     .|:            ..||.|..|.....:|||.|            |:..||..|
  Fly   174 SELR-----NYEDTWIGDSWKETTTLMDRDVAEEDEFDEDGYTD------------YMGEGFVPL 221

Human   597 QDVVEQAIIRVLTG-TEKKTGVYMQQM---PYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIK 657
            |..:....:|.... .||...|.|::.   |.....:.|     ..|:.|.:.|.:::.|.::..
  Fly   222 QYHISMQFLRATASKVEKLPKVVMRRFNENPNVLLSEGI-----GTSVVLLILLGFMFPVTILTT 281

Human   658 GIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLG--------NLLPYSD 714
            .||.|:|...:..::|:....::...:||.:.....|:::.|:.::||:.        |..|:
  Fly   282 LIVEERELGQRYMLKILNASATLQMAAWFFNVFTHFLITSLLITILLKIEWNGATAAVNKCPW-- 344

Human   715 PSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPY-----VLCVAWQDYVGFT 774
            |.::...:|....||.| ..|:::...|:.:|.....||:..|.||.     :|......:.||.
  Fly   345 PILLCFLISYGCSVTSL-IILMTSAMRRSRVAMVMAPIIWILLALPLLSKKELLSDGPDVFYGFA 408

Human   775 LKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMT 839
                ..||..|:|..|.......|:..:||.........|.:..|.:            ...::.
  Fly   409 ----TVLLCNVSFSRGLSKIFYIEDYTLGVTIGKYMFYRVSKSDFGI------------FVPIVC 457

Human   840 WYIEAVFPGQYGIPRPWYFPCT---------KSYWFG--------EESDEKSHPGSNQKRISEIC 887
            :|::.:|             ||         ..:|..        :....:|..|..:::|.|:.
  Fly   458 FYVQTIF-------------CTLLAMIFENNAYFWLAIRVKNLLKKYHATRSAVGRLKRQIPEVS 509

Human   888 MEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPP 952
            ..:  |..:..:..:.:.:.|.:...|..| :.||.|.|::.:.||||.:||:|.:.:|.|...|
  Fly   510 FSK--TSAEALIEFRGVWQKYSNSTYVVQD-ITLNVYAGEVVALLGHNASGKSTIIKMLYGRTRP 571

Human   953 TSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMAL 1017
            ..|..|:.|.:|.::.....:|..:...:..||..|.|.:|:.|.:||:|||:  .:|::|..||
  Fly   572 KLGEIYLSGFNIVTQRKEALKNSSISMSYKTLFTELVVLDHLVFLSRLRGLSK--TEAKLEAKAL 634

Human  1018 DVGLPSSKL----KSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY 1078
               |...||    |:..:.|:.|.:|.|....||.||:::||||:|..|:|.......:.|:|..
  Fly   635 ---LRYLKLEDWEKTLVNDLTIGQRRVLQFLCAFAGGNQIVILDKPFDGIDEQRTSLFYSLILDQ 696

Human  1079 RQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVK------KDV-- 1135
            ::.|:|..::::...|..:.|||.::|.|||...|:...|...|...|.|.:..      |||
  Fly   697 KKNRSIFFTSNNQKVASGIADRIFVLSKGKLQAFGTVKKLCRMLNESYRLIIFGNEKCSFKDVYA 761

Human  1136 -----------ESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRK 1189
                       :|.|:.|      .|:|.|                |:..|..|::  |.||
  Fly   762 FMATFIPEIEMDSILADC------ASFLVK----------------HKYHTELINL--IENL--- 799

Human  1190 HVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHE--IDDRLSDLGISSYGISETTLEEIFLKVA 1252
                |||..|:.     |..:|          .||  |||.|:.|    |...::|||      .
  Fly   800 ----ARLKNDLN-----VYSFE----------IHECSIDDILASL----YTRDKSTLE------F 835

Human  1253 EESGVDAETSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSY 1317
            .:.|:.      ||.|.|       :||..|.|
  Fly   836 GQPGLQ------TLLASR-------QQSAKRRF-------------------------------- 855

Human  1318 QVKGWKLTQQQFVALLWKRLLIARRSRKGF--FAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQ 1380
                  :....::....::|||| .:|..|  ..::.||::.|    |::|.:|.|
  Fly   856 ------IIPTMYLLEELRQLLIA-DTRNWFLPILKLTLPSLVV----VWTLSMPYF--------- 900

Human  1381 PWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTI 1445
             | :|                       .:.||..|
  Fly   901 -W-HN-----------------------CRQPGHIT----------------------------- 911

Human  1446 MDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLV 1510
                                        .|:...|.|.:   ..:::|.|          |:.||
  Fly   912 ----------------------------FPMSDHGDGII---LMQKDTLD----------SELLV 935

Human  1511 --KTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRF 1573
              :.|.::....:...:.:..|.|               :.|..:::.           |.||
  Fly   936 ASEMYAKVGVTEVDKTVDITTFIY---------------NYEYKNSLL-----------SDAD-- 972

Human  1574 LNSLGRFMTGLDTKN-NVKVWFNNKGWH----AISSFLNVINNAILRANLQKGENPSHYGITAFN 1633
                  .|..:...| .::|.||.|..|    :::..||.:..|.:..:.         ||....
  Fly   973 ------IMEAVIFSNVQIEVLFNTKWPHTAPDSLAQALNSLAVAFIDGDA---------GIKVEL 1022

Human  1634 HPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIY 1698
            ..|..:.....::.|.....|::.:.|:.|...|:.:..::.:...|..:..:::.|:|:..::.
  Fly  1023 EVLPFSTIHTLQLHLNIDGYDLIFASCLSFCFCFIWSIPLLHMTLSRDGRYNYVELIAGMPTIVL 1087

Human  1699 WLSNFVWDMCNYVV---PATLVII----------------IFICFQQKSYVSSTNLPVLAL---- 1740
            .::..::::...::   |..:.:|                :::.|...:.|.|.|:.:..:
  Fly  1088 IVAFLIYELLVVLLALFPINIAVIFFHWDLLMDSNIHIYSVYVMFIIAACVFSLNILITIMPISD 1152

Human  1741 -----LLLLYGWSITPLMYPA---SFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLN 1797
                 |.:|..:|:..|:|.|   ...|..|:||:.:|...:.|..:.             :.|.
  Fly  1153 MPFVYLKVLLAYSLGILVYIAVKELRPFTNPNTAHFLLLDFHPFYALL-------------HNLM 1204

Human  1798 NINDILKSVFLIFPHFCLGRGLID---------MVKNQAMADALERFGENRFVSPLSWDLVGRNL 1853
            .|..|.:.::|     |..|.:.:         .:.|....||.| |...|::..:...||
  Fly  1205 RIASISEKIWL-----CSDRQIYETSVYADQCNTIPNCCDDDAQE-FYHLRYLCCVYLLLV---- 1259

Human  1854 FAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKEL- 1917
                   ||:..|.:.:: ...::.||...|.  ..|.|.|.:.: |.||      .|:|..||
  Fly  1260 -------VVWISIFIFLK-SHMVKRRPRQPKY--FWDSDPDSKYD-QNIL------HIMEPSELE 1307

Human  1918 -TKIYRRKR-------------------------KPAVDRICVGIPPGECFGLLGVNGAGKSSTF 1956
             |.|:.:.|                         |.|:..|...:...:...:.|.||.|||...
  Fly  1308 NTWIHEKSRVSTLERNHIESKALHVEHLSVFFGLKAAIKHIDFMVNRYQVMSVFGANGTGKSVLL 1372

Human  1957 KMLTGDTTVTRGDAFLN-----KNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGV 2016
            |.:.|..|.:.|....:     |:..|.:.|.|    ||..|.....:|:|..|..:.  :||..
  Fly  1373 KTILGIYTPSSGRIISSKTVPFKSKDLDSCHMV----GYSAQEFQTMQLMTILETWDL--ILRIR 1431

Human  2017 PEKEVGKVGEWAIRKL----GLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDP 2077
            ..|::....|  ..||    ||.||........|.|..::||..:||:....::.||:|.|.:|.
  Fly  1432 RSKQISFRAE--ATKLCKIFGLYKYRFNSLSICSQGVLKRLSLGIALMSDAELILLDDPFTHLDI 1494

Human  2078 KARRFLWNCALSVVKEGRSVVLT-SHSMEECEALCTRMAIMVNGRFRCLGSVQHL-KNRFGDGYT 2140
            .::|.:.:....:.:.|.|::.| |.:.....||  |||.:.......:|..:.: :|.:...|.
  Fly  1495 VSQRSMLHIIHDLRRRGHSIIYTCSDTAYSTPAL--RMATLSYPGIAVIGEREEMQQNYYSSYYM 1557

Human  2141 IVVRI----AGSNPDL-----KPVQDFFGLAFPGSVLKEKHRNM--------------------- 2175
            :..||    .||..|.     :..:|..|..  |::|:.||:..
  Fly  1558 VETRIHLAELGSPIDFDSQSTEAKEDRAGTT--GTLLRHKHQEFSAAFTDSADRWKYLKLCGVIE 1620

Human  2176 ---------------LQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQS 2225
                           :.:.|.|.:..::||...|.::|:..:  .:||||.:::.||::..:.:|
  Fly  1621 NVFPHAIIKNVSFPRVCFWLSSHMYPMSRIVDTLHRNKQDFY--SFSVSQPSVNSVFLSIHRQKS 1683

Human  2226 DDD 2228
            :.|
  Fly  1684 NKD 1686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA1	NP_005493.2	rim_protein	6..2236	CDD:130324	399/2018 (20%)
		Annulus domain 1. /evidence=ECO:0000305|PubMed:35974019	69..80
		Annulus domain 2. /evidence=ECO:0000305|PubMed:35974019	368..379
		Gateway domain. /evidence=ECO:0000305|PubMed:35974019	564..594		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1283..1312		2/28 (7%)
CG43672	NP_788912.3	rim_protein	<266..>732	CDD:130324	120/505 (24%)
		ABC_subfamily_A	519..737	CDD:213230	69/223 (31%)
		P-loop containing Nucleoside Triphosphate Hydrolases	1330..1517	CDD:476819	47/194 (24%)