Protein Alignment ABCA1 and ldd

DIOPT Version :10

• Sequence 1: NP_005493.2
• Gene: ABCA1 / 19
• HGNCID: 29
• Length: 2261
• Species: Homo sapiens
• Sequence 2: NP_001285513.1
• Gene: ldd / 318066
• FlyBaseID: FBgn0083956
• Length: 1998
• Species: Drosophila melanogaster
• Alignment Length: 2452
• Identity: 560/2452 - (22%)
• Similarity: 917/2452 - (37%)
• Gaps: 714/2452 - (29%)

Human     6 QLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAG-TLPW 69
            ::|.||.|:|..|.||....|:.:|||:.:|::|..:||.|...|...|.:|.:.:|:.. .:|.
  Fly     9 EVRELLRKDLLVRWRQKGLSLILLAWPVMVFMLLYLIRLKYGSEELEACQYPTRLLPTKNQVVPA 73

Human    70 VQGIICNANNPC------FRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDTSMKDMRKV 128
            ....||:..|.|      ..|....|||                      |:|..|.
  Fly    74 AFSYICSIENRCQPAHPYEEYSHWKEAP----------------------LHSVIDV-------- 108

Human   129 LRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILHKVFLQGYQLHLTS 193
                           :..|:.|..           |.|:.|:...:|:      |:......:||
  Fly   109 ---------------VNAFVTDER-----------LHKAVVELAEKAN------FVSAITTLITS 141

Human   194 LCNGSKSEEMIQLGDQEVSELCGLPREKLAAAERVLRSNMDILKPILRTLNSTSPFPSKELAEAT 258
                    :...:....:||:..|..|    .||.:..:.||
  Fly   142 --------DRFDIIRSNISEIISLVPE----IERRMNYSFDI----------------------- 171

Human   259 KTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLN 323
                       :.|||.|                      :.:..:..::||||......|..:|
  Fly   172 -----------KHLFSNR----------------------ETFVKLGVLLCGHPFPNTDTIPLVN 203

Human   324 -WYEDNNYKALFGGNGTEEDA------ETFYDNST----TPYCNDLMKNLESSPLSRIIWKALKP 377
             ..|..::..   .|..|.||      ..:.|..|    |.||..|.:::.|:...::.|..:||
  Fly   204 EILESEDFSQ---ANDAEIDAMPTRRRRRYEDLPTDWRPTKYCKRLYRDVTSTNQGKLTWNTIKP 265

Human   378 LLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPKIWTFMENSQEMDLVRMLLDS 442
            ::.|:|||||....|..|:...|.:|:||.....|......:..|:.|
  Fly   266 IIQGRILYTPANAMTESVVKFSNASFEELDRLKQLSRAAATILTKLHT----------------- 313

Human   443 RDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGSVYTWRE-----AFNETNQAI----RTI 498
              |..|.|         |.|.:..|||.|. |:|..|..:...|     .:..|||.|    .|:
  Fly   314 --NATFQE---------AFDNLLKLAKSPL-VKSLVGDDFDIGEIERVFEYIRTNQLIYDILTTV 366

Human   499 SRFMECVNLNKLEPIATEVWLINKSMELLDERKFWAGIVF--TGITPGSIELPHHVKYKIRMDID 561
            :..|:||:.::.|.:.:...|..::.||...:.|.|.:..  .|:...|        |::.||.|
  Fly   367 ADLMDCVSADRFEAVESVEELHKRAYELNQNKLFLAALNLEDVGLKQAS--------YRLHMDTD 423

Human   562 NVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAII-------------------RV 607
            |.:.|.:.::.:|.|||......|::| ..||..|:.:|:..||                   |.
  Fly   424 NTQPTFENRNRFWFPGPADSMVIDLKY-HRGFVQLKQMVDLGIIKSKREEAGFAPEEDGPESGRS 487

Human   608 LTG-------------------------------------------------------------- 610
            |:|
  Fly   488 LSGLFSIKQVENDTPDEDDDDFDLSLEESGDEKAAPKVSASASDHEATTISPSSLDGVTTEEVRV 552

Human   611 -TE----------------------KKTGV--------------------------YMQQMPYPC 626
             ||                      |:.|:                          |.:|.|||.
  Fly   553 TTEQTVVSGDPDLLLLKNEDVLKRSKRQGLFDLLGGFGGSGDANKKNKFEVDNMQFYTKQFPYPA 617

Human   627 YVDDIFLR--VMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISS 689
            :::|:|.|  .:::.:.:...|..:..||:.::..::.:|:|....||.|||.......:|.:.|
  Fly   618 FLNDVFKRGLYLAQGVQVAYLLGLVVFVALSVRERIWMRESRNSMLMRSMGLKAHSELVAWALMS 682

Human   690 LIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIY 754
            .:.|.|...|:..:|..|.:|.|::...:..:...|.:..|..|::.:..|:.||:.|....:::
  Fly   683 FLELCVIFALISGVLYSGGILGYTNWFFMMFYCLSFGLCLISFCYMCTNFFNSANIGAVASALLF 747

Human   755 FTLYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGF 819
            |....|:::.:.:.    ..|.:|.|.|..::|           .......|..|....::::|.
  Fly   748 FISLCPFIIVLMFD----AKLSVFESFLVDLSF-----------TTAFAKGWGELIRMELQQEGL 797

Human   820 NL-------------TTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESD 871
            .:             ..::.|.|.|..||.|:            |:          :|...:::|
  Fly   798 TVRHLIQVGPARSECAMALLMFLLDLLLYAVI------------GL----------AYQRYKKTD 840

Human   872 EKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNG 936
            ..|....::.::..          |||.|:.|:.|:|  |.|.||..|:|:|...|::..||.||
  Fly   841 NYSFVKVSRSQLDG----------KLGASLVNVSKLY--GSKCAVSNLSLDFARNQVSCLLGRNG 893

Human   937 AGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLK 1001
            |||:|.:.:|||....:||...:.|:          ..:|||.|.|:|...||..||:..||::|
  Fly   894 AGKSTLIKLLTGQIRQSSGKVLLAGE----------HQVGVCWQDNILIPTLTAREHLQLYAQIK 948

Human  1002 -------GLSEKHVKAEMEQ--MALDVGLPSSKLKSKTS-QLSGGMQRKLSVALAFVGGSKVVIL 1056
                   |:.|  :::|:.|  .:|:.|    |.:|..| |||||.:|:|.||:||:....||||
  Fly   949 IPPGGSGGVEE--IRSEVAQTLQSLNFG----KHESYPSWQLSGGYRRRLCVAIAFIASPSVVIL 1007

Human  1057 DEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQ 1121
            |||..|||..:|:.||:|:.:.||||.:|.:||.||||..|.|.:.|:.:|::....|...|:..
  Fly  1008 DEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQRL 1072

Human  1122 LGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNL 1186
            ..:.|.:.|          .|.:::.....::|...:...:.....|:.....:|||:.|...:|
  Fly  1073 CTSNYSIRL----------RCADATGVTFVIQKAQQLLPQTQVTHSGAADYPHSLTINASYAEHL 1127

Human  1187 IRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHE--IDDRLSDLGISSYGISETTLEEIFL 1249
            ....|.                         |:||...  ....:||:.:::....|...|::
  Fly  1128 TPGAVE-------------------------FLELLQSQVTAGSISDVELTTSSSLEQEFEQL-- 1165

Human  1250 KVAEESGVDAETSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGK 1314
               ..:|.||..          ||...|:...:        |.|.....:|.:
  Fly  1166 ---NRNGEDAGP----------RRPASDRSGVV--------AGPAMITDEPPT------------ 1197

Human  1315 GSYQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLEL 1379
                      ..:||..|:.|||....|:.:.....::|||:|...|:
  Fly  1198 ----------ACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAM----------------- 1235

Human  1380 QPWMYNEQYTFVSNDAPEDTGT-LELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQ 1443
              |       |||....:|..| |.|..:|                                .||
  Fly  1236 --W-------FVSYRLEDDFDTVLPLSRSL--------------------------------YPQ 1259

Human  1444 TIMDL-FQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISD 1507
            |...| .:......:...|..:.|.|.:.:    |           |..||:....|....:..:
  Fly  1260 TAQFLSHERATSFSEKLYPQLRTSCDHLGE----C-----------RVFNTSQQSYDWVLNSWGE 1309

Human  1508 YLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADR 1572
            |                   :|.||||:.|..|
  Fly  1310 Y-------------------SERRYGGYGLNGS-------------------------------- 1323

Human  1573 FLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLN 1637
                            ...||:||||:|::.::||.:|:.:||..:    |.|...|...|.|..
  Fly  1324 ----------------GATVWYNNKGYHSMMAWLNDLNSELLRTTM----NDSESSILTLNEPWK 1368

Human  1638 LTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSN 1702
            |...:||..:::..:.|..:...::.|...|.||..|:|:.|||:..|..|.:.||..|.|||..
  Fly  1369 LGFAELSTSSILRQAGDGSMVFILLIAFGLVVASGSVYLVNERVNGEKLQQRLCGVSAVTYWLVA 1433

Human  1703 FVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAY 1767
            .|||....|:...:.:::.:.|....:|....|..:..|.|.:.::..|.::.|..:|...|.|.
  Fly  1434 LVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQLVGIIGLSLAFSFACVPSVHVAEKIFSDSSIAI 1498

Human  1768 VVLTSVNLFIGINGSVATFVLELFTDNKL-NNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADA 1831
            |.:...||.:.:.......:|.:..|... ::....|...|||||...||.|.:::.||..:|..
  Fly  1499 VSIFCANLIVPLVTMGIILILGVVGDGPAWDDWRHALNQAFLIFPIHALGDGFLELCKNYMVALV 1563

Human  1832 LERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRP-RPVNAKLSPLNDEDEDV 1895
            ..|:..:.:..||:.||:||:..|:.:.||...:|.|||::....|. :.|...|      |...
  Fly  1564 FRRYDIDSYKHPLASDLLGRHFTALLLVGVAALIINVLIEWHLLRRLWQRVERLL------DCTY 1622

Human  1896 RRERQRILDGGGQNDILEIKELTK----------------IYRRKRKPAVDRICVGIPPGECFGL 1944
            |||    ||..||..::.|:.:.|                .|||... ||..:...:..||||||
  Fly  1623 RRE----LDKLGQLKLVNIQSIFKSCVDTGEAVRAENLWLAYRRGHY-AVRNVNFSVQRGECFGL 1682

Human  1945 LGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEF 2009
            ||.||||||:.||:|||......|..:..:..|           .||||.:.:..|||..|.:.|
  Fly  1683 LGKNGAGKSTIFKLLTGQLQPDVGQIYFEQPGI-----------SYCPQSNPLDPLLTTTECIRF 1736

Human  2010 FALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTG 2074
            :..|||:  :::.:..:..:....|..|.:....|.||||:|||:.|:...|..|.|.:||||:.
  Fly  1737 YGRLRGI--RDLDQFLDRVLDTYELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSD 1799

Human  2075 MDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGY 2139
            |||..|..::.....::...|:|||||||:.|.|.||.|:|::..|:.....|.|.||:..| ||
  Fly  1800 MDPVTRDMVYATIEQLLLARRAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHG-GY 1863

Human  2140 TIVVRIAGSNPDLKPVQD-----FFGLAFPGSVLKEKHRNMLQY----QLPSSLSS---LARIFS 2192
            ..|....|      |.|.     ......||:...:.:.:.|::    :.|.||..   |:.:|:
  Fly  1864 YAVTCFCG------PAQQAILSRSLNQRLPGARDLQHYAHSLRFLVRVRSPGSLGDAPLLSELFA 1922

Human  2193 ILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQ 2239
            ||..  ..:::..:|:|:...:.||.... |.|:.:...  .:||:|
  Fly  1923 ILCD--VCVNVARFSLSRCRFETVFERIL-DSSESNGSN--GVHKDQ 1964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA1	NP_005493.2	rim_protein	6..2236	CDD:130324	557/2447 (23%)
		Annulus domain 1. /evidence=ECO:0000305|PubMed:35974019	69..80		2/10 (20%)
		Annulus domain 2. /evidence=ECO:0000305|PubMed:35974019	368..379		3/10 (30%)
		Gateway domain. /evidence=ECO:0000305|PubMed:35974019	564..594		8/29 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1283..1312		3/28 (11%)
ldd	NP_001285513.1	rim_protein	179..1867	CDD:130324	483/2042 (24%)