DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pou5f1 and pdm2

DIOPT Version :9

Sequence 1:	NP_038661.2	Gene:	Pou5f1 / 18999	MGIID:	101893	Length:	352	Species:	Mus musculus
Sequence 2:	NP_001285877.1	Gene:	pdm2 / 34673	FlyBaseID:	FBgn0004394	Length:	893	Species:	Drosophila melanogaster

Alignment Length:	244	Identity:	102/244 - (41%)
Similarity:	143/244 - (58%)	Gaps:	43/244 - (17%)

- Green bases have known domain annotations that are detailed below.

Mouse    92 GQAGARVESNSEGTSSEP----CADRPN-----AVKLEKVEPTPEESQDMKALQKELEQFAKLLK 147
            |.:.|.:..|:.....:|    ...:|.     |..:.|:|.:|||:.|:    :|||||||..|
  Fly   637 GMSSAVMTPNTPSMQQQPQLQQSTPKPTSGLTVASAMAKLEQSPEETTDL----EELEQFAKTFK 697

Mouse   148 QKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEALQLSLKNMCKLRPLLEKWVEEADNNENLQE 212
            |:||.||:||.||||.:|.|:|..||||||.|||||.||.||||||:|||:||:|:||:.
  Fly   698 QRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLEDADST----- 757

Mouse   213 ICKS------------------ETLVQARKRKRTSIENRVRWSLETMFLKCPKPSLQQITHIANQ 259
            :.||                  |:::..|::||||||..||.:||..||...||:.::|:.::.:
  Fly   758 VAKSGGGVFNINTMTSTLSSTPESILGRRRKKRTSIETTVRTTLEKAFLMNCKPTSEEISQLSER 822

Mouse   260 LGLEKDVVRVWFCNRRQKGKR--SSIEYSQREEYEATGTPFPGGAVSFP 306
            |.::|:|:||||||||||.||  .|::..     ..||||....|..:|
  Fly   823 LNMDKEVIRVWFCNRRQKEKRINPSLDLD-----SPTGTPLSSHAFGYP 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pou5f1	NP_038661.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..115		4/26 (15%)
		POU	131..205	CDD:197673	48/73 (66%)
		DNA binding. /evidence=ECO:0000269\|PubMed:23376973, ECO:0007744\|PDB:3L1P	173..179		5/5 (100%)
		DNA binding. /evidence=ECO:0000269\|PubMed:23376973, ECO:0007744\|PDB:3L1P	186..189		1/2 (50%)
		Homeobox	226..279	CDD:278475	28/52 (54%)
pdm2	NP_001285877.1	POU	691..755	CDD:197673	44/63 (70%)
pdm2	NP_001285877.1	Homeobox	789..842	CDD:278475	28/52 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810