DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pou3f2 and nub

DIOPT Version :9

Sequence 1:	NP_032925.1	Gene:	Pou3f2 / 18992	MGIID:	101895	Length:	445	Species:	Mus musculus
Sequence 2:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster

Alignment Length:	417	Identity:	159/417 - (38%)
Similarity:	190/417 - (45%)	Gaps:	127/417 - (30%)

- Green bases have known domain annotations that are detailed below.

Mouse    86 GGGDGSPWSTSPLGQPDI---------KPSVVVQQGGRGDELHGPGAL----------------- 124
            |.|..:|..|..|...|.         :...:.||.....||...|:|
  Fly   588 GLGMNNPLLTGSLSPQDFAQFHQLLQQRQVALTQQFNSYMELLRSGSLGLAQDDPALTAQVAAAQ 652

Mouse   125 -QQQHQQQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHP---------GPGAWRSAAAAAHL 179
             ..|.|.|...|..||.|..|:|||:|...|..::|.....|         .|.|.||.|::
  Fly   653 FLMQSQLQALSQASQQLQALQKQQQRQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPASS--- 714

Mouse   180 PPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQ-QPP- 242
                                         |..||||                  |.||.| .||
  Fly   715 -----------------------------PQQLHHH------------------HHHPLQITPPS 732

Mouse   243 ------------PPPPPQGPPGHPG----------------AHHDPHSDEDTPTSDDLEQFAKQF 279
                        |..|..|.....|                |..:| |.|:|...::||||||.|
  Fly   733 SAASLKLSGMLTPSTPTSGTQMSQGTTTPQPKTVASAAAARAAGEP-SPEETTDLEELEQFAKTF 796

Mouse   280 KQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSP 344
            |||||||||||.|||||:|.||||.||||||.|||||.|||||||||||||.|||::||.:..:.
  Fly   797 KQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLDDADRTIQAT 861

Mouse   345 TSI-DKIAAQ---------GRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEV 399
            ..: |..|.|         ||:||||||||.:::||||..||...||:::|||.|||.|.:||||
  Fly   862 GGVFDPAALQATVSTPEIIGRRRKKRTSIETTIRGALEKAFLANQKPTSEEITQLADRLSMEKEV 926

Mouse   400 VRVWFCNRRQKEKRMTPPGGTLPGAED 426
            ||||||||||||||:.|...:..||:|
  Fly   927 VRVWFCNRRQKEKRINPSLDSPTGADD 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pou3f2	NP_032925.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..173		30/122 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..269		20/95 (21%)
		POU	264..338	CDD:197673	57/73 (78%)
		Homeobox	359..413	CDD:395001	37/53 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..445		7/16 (44%)
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	53/63 (84%)
		Homeobox	886..939	CDD:278475	36/52 (69%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810