DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pou2f2 and pdm2

DIOPT Version :9

Sequence 1:XP_006539710.1 Gene:Pou2f2 / 18987 MGIID:101897 Length:717 Species:Mus musculus
Sequence 2:NP_001285877.1 Gene:pdm2 / 34673 FlyBaseID:FBgn0004394 Length:893 Species:Drosophila melanogaster


Alignment Length:544 Identity:209/544 - (38%)
Similarity:261/544 - (47%) Gaps:129/544 - (23%)


- Green bases have known domain annotations that are detailed below.


Mouse    27 LDSPSEHTDTERNGPDINHQNPQNKA-SPFSVSPTGPSTKVGILSGLHLTF------WGPGPC-- 82
            :|.|.|.:..|:..|:..|..|.||. ...|.|||.|| .:..||....:|      .|.. |  
  Fly   419 VDPPKEPSIYEQPAPNGRHCRPANKVMRHMSNSPTPPS-PLRSLSDCGKSFEEEELELGEN-CEM 481

Mouse    83 -----------------------LSPPQIKAEDPSGDSAPAAPPPPQP---AQPHLPQAQLMLTG 121
                                   |:||..:..:...:...|:..||||   |...:.||..:...
  Fly   482 PQNLSSKRQARELDSELENEVLDLAPPPKRLAEEQEEEKVASVNPPQPVAFAPEEMHQALQLQLH 546

Mouse   122 SQLAGLSALIP--------AQQQLLLQQAQAQLLAAAVQQSSAAAANAAAAAAAASTSSSTSSAS 178
            |.:..:..|.|        |.|.||....||.....|:||..           .........|.|
  Fly   547 SYIEMVRQLAPEAFPNPNLATQFLLQNSLQALAQFQALQQMK-----------QQQREDPLPSYS 600

Mouse   179 SSTSQTPASSGGGDLPPSQPTSQPPGTPQLTLSQPIQLTAQDIQQLLQLQQLVLVPGHHLQPPAQ 243
            :..:::|..|     |...|..:...:.|.|  .|..:||..    |.:...|:.|.        
  Fly   601 TPLAKSPLRS-----PSLSPVPRHSKSQQRT--PPNSMTANS----LGMSSAVMTPN-------- 646

Mouse   244 FLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLP-TQAMTRPTLPDPHLSHPQPPKCLE 307
                           ||::.|.||..|.   |.:|.:||. ..||.:                ||
  Fly   647 ---------------TPSMQQQPQLQQS---TPKPTSGLTVASAMAK----------------LE 677

Mouse   308 PPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNM 372
              ..|||.:|||||||||:||||||||||||||||||||||||||||||||||||||||||||||
  Fly   678 --QSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNM 740

Mouse   373 CKLKPLLEKWLNDAETMSVDS--SLPSPNQLSSP-SLGFDGLPGRRRKKRTSIETNVRFALEKSF 434
            |||||||:|||.||::....|  .:.:.|.::|. |...:.:.||||||||||||.||..|||:|
  Fly   741 CKLKPLLQKWLEDADSTVAKSGGGVFNINTMTSTLSSTPESILGRRRKKRTSIETTVRTTLEKAF 805

Mouse   435 LANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPMLPSP-GKPTS-----YSP 493
            |.|.|||||||..::|:|:|:||||||||||||||||||||   :..|.|| |.|.|     |.|
  Fly   806 LMNCKPTSEEISQLSERLNMDKEVIRVWFCNRRQKEKRINP---SLDLDSPTGTPLSSHAFGYPP 867

Mouse   494 HLVT-----PQGGAGTLPLSQASS 512
            ..:.     .:||:|:...|..||
  Fly   868 QALNMSHMQMEGGSGSFCGSSISS 891

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pou2f2XP_006539710.1 PRK10263 <206..>334 CDD:236669 40/128 (31%)
POU 313..387 CDD:197673 68/73 (93%)
Homeobox 418..472 CDD:365835 40/53 (75%)
pdm2NP_001285877.1 POU 691..755 CDD:197673 60/63 (95%)
Homeobox 789..842 CDD:278475 39/52 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 142 1.000 Domainoid score I4663
eggNOG 1 0.900 - - E1_KOG3802
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003004
OrthoInspector 1 1.000 - - mtm8890
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11636
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
55.000

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