DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pou2f1 and nub

DIOPT Version :9

Sequence 1:	NP_035267.2	Gene:	Pou2f1 / 18986	MGIID:	101898	Length:	793	Species:	Mus musculus
Sequence 2:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	216/562 - (38%)
Similarity:	281/562 - (50%)	Gaps:	129/562 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse    22 SRMNNPSETNKSSMESEDASTGTQTNGLDFQKQPVPVGGAISTAQAQA----------------- 69
            ||..:|.::|.|..:..::|.||.::     :...|:..|:|.:..||
  Fly   409 SRSPSPLQSNASDCDDNNSSVGTSSD-----RCRSPLSPALSLSHQQAKRQLMSLQPHPAHHHHN 468

Mouse    70 --FLGHL--HQVQLAGTSLQAAAQSLNVQSKSSEESGDSQQS-------------SQPSSQPPSV 117
              .|.||  ||.:.......|...:||:.|.:|..|..|..:             |.||..||.:
  Fly   469 PHHLNHLNHHQYKQEEDYDDANGGALNLTSDNSRHSTQSPSNSVKSATASPVPVISVPSPVPPMI 533

Mouse   118 QSAI------------------------------------------PQTQLMLAG-GQ----ITG 135
            ...:                                          ||.||..|| |.    :||
  Fly   534 SPVLAPSGCGSTTPNSMAAAAAAAAAVASTMGSGISPLLALPGMSSPQAQLAAAGLGMNNPLLTG 598

Mouse   136 LTLTP---AQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGA----------TISASAATPMTQ 187
             :|:|   ||...||||.|      .|..||.::..:...:|:          |...:||..:.|
  Fly   599 -SLSPQDFAQFHQLLQQRQ------VALTQQFNSYMELLRSGSLGLAQDDPALTAQVAAAQFLMQ 656

Mouse   188 IPLSQPIQIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQL 252
            ..|....|.:|.||.||:.||:.:: :...|.|..|. ||.    |.||...:..:..::..:.
  Fly   657 SQLQALSQASQQLQALQKQQQRQVD-EPLQLNHKMTQ-QPR----SSTPHSIRSPIAIRSPASS- 714

Mouse   253 PQQ---SQANLLQPQP-----SITLTSQ--PTTPTRTIAAASVQTLPQ-----SQSTPKRIDTPS 302
            |||   ...:.||..|     |:.|:..  |:|||.....:...|.||     |.:..:....||
  Fly   715 PQQLHHHHHHPLQITPPSSAASLKLSGMLTPSTPTSGTQMSQGTTTPQPKTVASAAAARAAGEPS 779

Mouse   303 LEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLK 367
            .||.:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   780 PEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLK 844

Mouse   368 PLLEKWLNDAE-NLSSDSTASSPSALNSPGLGAEGLNRRRKKRTSIETNIRVALEKSFMENQKPT 431
            |||:|||:||: .:.:......|:||.:.....|.:.|||||||||||.||.||||:|:.|||||
  Fly   845 PLLQKWLDDADRTIQATGGVFDPAALQATVSTPEIIGRRRKKRTSIETTIRGALEKAFLANQKPT 909

Mouse   432 SEDITLIAEQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSS 473
            ||:||.:|::|:|||||:||||||||||||||||.....|.:
  Fly   910 SEEITQLADRLSMEKEVVRVWFCNRRQKEKRINPSLDSPTGA 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pou2f1	NP_035267.2	POU	304..378	CDD:197673	69/73 (95%)
Pou2f1	NP_035267.2	Homeobox	408..461	CDD:278475	40/52 (77%)
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	61/63 (97%)
		Homeobox	886..939	CDD:278475	40/52 (77%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	142	1.000	Domainoid score	I4663
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	276	1.000	Inparanoid score	I2927
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8890
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9475
SonicParanoid	1	1.000	-	-		X2466
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.990