DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zeel-1 and CG12084

DIOPT Version :9

Sequence 1:	NP_490966.2	Gene:	zeel-1 / 189770	WormBaseID:	WBGene00021463	Length:	917	Species:	Caenorhabditis elegans
Sequence 2:	NP_612112.1	Gene:	CG12084 / 192509	FlyBaseID:	FBgn0043458	Length:	793	Species:	Drosophila melanogaster

Alignment Length:	828	Identity:	157/828 - (18%)
Similarity:	304/828 - (36%)	Gaps:	237/828 - (28%)

- Green bases have known domain annotations that are detailed below.

Worm   193 LNVNALKKNERKEGFLNHCNTAYRLPHKMTSSLANITAAQIARHINDGRYTRTNILEGMDTKFRD 257
            ||...:..||..:|||.:..   |....:..|        :.|...|...|...|:     ..|:
  Fly    46 LNPGIVLPNEICDGFLENYQ---RFNRPLDDS--------VIRLFEDTHRTSLKIV-----NLRN 94

Worm   258 TILSKLLLLNPKAYQFIAKTTQVEKSLSIGKRVFELEYYARHKSIITTLTIVLHKKKYWEKIQKL 322
            :.||.:.|.....::..|.:......:|:|.......|....:|:  .|.|..|..:|.|..:|.
  Fly    95 STLSSIGLETLMRHKLFALSLWYCDMISVGSHHLLAHYGDSLRSL--ELGISSHLLQYAEPNEKE 157

Worm   323 DIRECEAQLTPGWVKQI---GIMLSSLTTLEISNKPLSKEDFSELCDSFPNLVQLDISDTGIR-- 382
            .:   :.|||...::::   |:::.            .:..|:.|.|    |..||::...:.
  Fly   158 PV---DFQLTCPHLRRLVLNGVVMH------------HRLQFAHLHD----LGHLDLTSCVLANF 203

Worm   383 KLDGIFKLKHLKVLWMRNLQFECSSDMLDLFKLTGLTALDVS-------RDVYKTNIKTIMQFVE 440
            .|:.:..|.:|..|.:.|: :..::.:..:..|..|..||:|       ...|....:|:...::
  Fly   204 SLEALGSLPNLHTLILFNV-WPIANQLHAICCLRRLCTLDISISSSGNGHGTYDLPDQTLEMLMD 267

Worm   441 CGIILPNLTFLDASGTDLNEN--------LLNSLASHPKLQQIVAIDTNVQYIKTTGHEILSFGN 497
               .|.:||.||.|||:|..|        ..:.:...||::|..|: |::..:.:.....|.|
  Fly   268 ---NLRHLTHLDISGTNLAGNGVATKESTTTSGMQQSPKMEQHFAL-TDIPGLASRTQRPLQF-- 326

Worm   498 LQTSLRILKHFVNLKRSVATRKCLLRITTQLKQFHNDTKQYDVVKCLRHAIEAIETF-RPNEQ-- 559
                                          |..:|  |..:   .|.||.|.|:|.. ..|||
  Fly   327 ------------------------------LGLYH--TAHW---ACKRHDIPALEVAGDANEQQI 356

Worm   560 LKAEIRWNDNTYITGLNCLIEISRNKSHIF---HPLDAKLVLDILLIASERIL-----PLTSSAL 616
            |.|...::|...:     |..:..:..|:|   :..|....||::|.|.:|.|     .::.||
  Fly   357 LTAARYYHDRPVL-----LTRVLNDLYHLFRFENCKDIHTALDVVLSAMDRHLKFKHMQISGSA- 415

Worm   617 QHPCQAVWEAIQNLVDQEFDWLDYDQIGTSAMRFALEVYLRPDRFL----------NQATSVVET 671
                 .::..::.....:|..|..:.|..:.:. .:|:::..|..|          :....|:..
  Fly   416 -----TLFYIVKGRDRSKFGALLRNHIIRTLLN-GMEMHITDDTMLRNGYLTLTQFHMPVDVLFE 474

Worm   672 CTRL--------SPSQDFSGYLEKKLTTCVINLIKEEIINGNERQCISFLKIVYSM-TL----CS 723
            ..||        |.::. .|::: ::...::|.:..: ::|.::..:..|.:|.:| ||    .:
  Fly   475 YERLIKILLHGVSKTEQ-EGFVQ-RIAIYLLNTLACQ-VDGRQKLFLGELGVVSTMFTLIKDRLT 536

Worm   724 KSACEDILKNGKFASLVWCLQ-----NC------NSDELHLEVLH-------VIRNL-----SIV 765
            :|..:|:::..  .|.:|.:.     ||      ...|..|:.||       ::||:     ::.
  Fly   537 RSVFDDVMEVA--WSTMWNVTDETAINCKRFLDGRGMEYFLKCLHTFPDRDELLRNMMGLLGNVA 599

Worm   766 HKSSIFKKHFTATEFKVFHQLLNDW-----------------------TSNKAYNVFTI------ 801
            ....:..|..|....:||.:||:..                       ::|.||..|.:
  Fly   600 EVKWLRPKLMTQEFIEVFARLLDSLSDGIEVGGASASVVARVREREMASANHAYLRFQVSYNAAG 664

Worm   802 ISLRIFSSERD-WTTCEFSSDANDLLIDR-----------------FRYFQPSEITEKVEIYLGI 848
            :...|.|...| ||   ..:.:.:.:::|                 :|.|:|  |...|..|
  Fly   665 VLAHIASDGADAWT---IKTPSREHVLERMVAAIQRWNIKSERNINYRSFEP--ILSLVRCY--- 721

Worm   849 LEDVLKTSRLEGPVLWALLTL-QILTEQKKEFVET---IEEYSYILKH 892
                 :|.:.:...:|||..| |:..|:..:.||.   |:..:.:::|
  Fly   722 -----ETPQCQHWAVWALANLTQVYPEKYCKLVEQENGIQILNELIEH 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zeel-1	NP_490966.2	leucine-rich repeat	346..370	CDD:275380	3/23 (13%)
		leucine-rich repeat	371..392	CDD:275380	5/22 (23%)
		leucine-rich repeat	393..417	CDD:275380	4/23 (17%)
		leucine-rich repeat	418..447	CDD:275380	7/35 (20%)
		leucine-rich repeat	448..471	CDD:275380	9/30 (30%)
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	4/24 (17%)
		leucine-rich repeat	136..167	CDD:275381	10/35 (29%)
		leucine-rich repeat	168..189	CDD:275381	3/32 (9%)
		leucine-rich repeat	190..213	CDD:275381	5/22 (23%)
		ARM	535..628	CDD:237987	18/94 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3665
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900