DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Polg and tam

DIOPT Version :9

Sequence 1:	NP_059490.2	Gene:	Polg / 18975	MGIID:	1196389	Length:	1217	Species:	Mus musculus
Sequence 2:	NP_476821.1	Gene:	tam / 34792	FlyBaseID:	FBgn0004406	Length:	1145	Species:	Drosophila melanogaster

Alignment Length:	1234	Identity:	542/1234 - (43%)
Similarity:	710/1234 - (57%)	Gaps:	167/1234 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse    25 WVSSSV-----LDPVPSDGRPPSQMPSSENG--QLRLNPLLIQMLSRGLHEQIFGCGGEMPDEAA 82
            :.||||     :.| |.....|.:..:.|||  :...|.:.:||:||.||.|:|   .:.|...:
  Fly    18 YASSSVKIFRRVKP-PQKVNKPKKPENVENGPTEYAENLVKVQMISRNLHAQLF---PQAPRSIS 78

Mouse    83 VQRSV------EHLQKHGLWGQPATPLPDVELRLPRLFGGNLDQHFRLLAQKQSLPYLEAAASLL 141
            .|:..      :.|::||:..:.:.|:.||:|:||.|.|.|:::||..:|::|..||.|....|:
  Fly    79 EQQVASAKVYKDELRRHGVDIESSAPVSDVQLKLPALRGANIEEHFHNIAKEQVQPYEELLLPLV 143

Mouse   142 EA-QLPPEPKSWAWAEGWTRYGPE-GEAEPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWY 204
            :. |||..||.||:..|||.|.|| |.|.||..|.|:.||||||||::||..|.||.|:|...||
  Fly   144 QCEQLPKRPKRWAFHTGWTAYDPEDGTATPVDHPLEKGLVFDVEVCVSEGQAPVLATAVSTKRWY 208

Mouse   205 SWCSRRLVEERYSWTSQLSPAD--------------LIPLGGSTSASSSTKQDGQEQLVVGHNVS 255
            ||.|.:|.:.|.| ..:|.|.|              |||||        |...|   ||||||||
  Fly   209 SWVSSKLTKHRLS-VEKLEPLDVDTDSERPHYTTDELIPLG--------TTGPG---LVVGHNVS 261

Mouse   256 FDRAHIREQYLIQDSRMRFLDTMSMHMAISGLSSFQRSLWMGAKQGKHKTQQSTKRGQKSPRKAN 320
            :|||.::||||.:|:..||:||||:||.:||::|:||::....|:
  Fly   262 YDRARLKEQYLTEDTGTRFVDTMSLHMCVSGVTSYQRAMLKSKKE-------------------- 306

Mouse   321 GPAISSWDWMDISSANNLADVHNLYVGGPPLEKEPRELFVKGSMRDIRENFQDLMQYCARDVWAT 385
             ||.....|::.||.|:|.:||.||.||..|.||||.:||:|::..:|::||.|..|||.||.||
  Fly   307 -PAAEDLGWLEQSSLNSLVEVHRLYCGGDTLSKEPRNIFVEGTLEQVRQSFQSLTNYCASDVEAT 370

Mouse   386 FEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLTEAQNTYEELQREMKKSLMDLAN 450
            ..:.:...||:.||.|||.:||||||||.:|||||.|||||:.|||.|||:|..|.|..|...|.
  Fly   371 HRILRVLYPLYAERFPHPASLAGMLEMGSAYLPVNSNWERYIREAQLTYEDLSIEAKYHLGRRAE 435

Mouse   451 DACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKPASASKLPIEGAGPFGDPMDQEDPGPPS 515
            :||.||..::|:::.||||.:|.:||.|.|:..| :||     ||         .::.:|.|...
  Fly   436 EACSLLLDDQYRQNLWLWDEDWSVQELKLKQPPK-RKP-----LP---------TVELKDSGNTP 485

Mouse   516 EEEELQRSVTAHNRLQQLRSTTDLLPKRPQHLPGHPGWYRKLCPRL-----------DDPAWAPG 569
            ||..||.      :.|.|.....|||.|...|||:|.||||||.:.           |:..|:||
  Fly   486 EERRLQA------KFQHLYDQQALLPARRPLLPGYPLWYRKLCRKPPAKRADEILEDDEEPWSPG 544

Mouse   570 PSLLSLQMRVTPKLMALTWDGFPLHYSDSHGWGYLVPGRRDNLTEPPVSPTVESAAVTCPYRAIE 634
            .|.:|..|::.|||::|.|:|:||||....|||:|||.|.|  :|......:|.....||..
  Fly   545 ASEISTGMQIAPKLLSLCWEGYPLHYEREQGWGFLVPFRSD--SEGVDRLPMEQLLAHCPVP--- 604

Mouse   635 SLYRKHCLEQGKQQLEPQEVDLAEEFLLTDSSAMWQTVEELGCLDVEAEAKMEN-SGLSQPLVLP 698
                    |..:......|.|:|.:.|      ..|..:.||        |.|: ..|||
  Fly   605 --------EFARLSASKAESDMAFDML------PGQVEQHLG--------KREHYKKLSQ----- 642

Mouse   699 AACAPKSSQPTYHHGNGPY-NDVNIPGCWFFKLPHKDGNNYNVGSPFAKDFLPKMEDGTLQAG-P 761
                .:....|.:.|:|.: |.|....|:|.|||||:|.::.||:|.:||||.|..:..|.:| |
  Fly   643 ----KQQRLETQYQGSGVWCNKVLDDCCFFLKLPHKNGPSFRVGNPLSKDFLNKFAENVLSSGDP 703

Mouse   762 GGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRVVTRHPSFDEEGHYGAILPQVVTAG 826
            ...:..|.::|.:|:|:|||...||..||||||....||...|....  :...||||.||||..|
  Fly   704 SCQAAARVIDIARMMSYWRNNRDRIMGQMVVWLDSQQLPNEFTGEKC--QPIAYGAICPQVVACG 766

Mouse   827 TITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYVLVGADVDSQELWIAAVLGDAHFAGMHGC 891
            |:||||:||||:||||:||||:||||::||||||||.||||||||||||||:|||||:..|.||.
  Fly   767 TLTRRAMEPTWMTASNSRPDRLGSELRSMVQAPPGYRLVGADVDSQELWIASVLGDAYACGEHGA 831

Mouse   892 TAFGWMTLQGRKSRGTDLHSKTAATVGISREHAKIFNYGRIYGAGQSFAERLLMQFNHRLTRQEA 956
            |..|||||.|.||.|:|:||.||..|||||:|||:.||.|||||||.|||.||.|||...:..||
  Fly   832 TPLGWMTLSGSKSNGSDMHSITAKAVGISRDHAKVINYARIYGAGQLFAETLLRQFNPTFSASEA 896

Mouse   957 AEKAQQMYAVTKGLRRYRLSADGEWLVKQLNLPVDRTEDGWVSLQDLRMIRREASRKSRWKK--- 1018
            ..||.:|:::|||.|.|||                 .|:....|:|......||||.:..:.
  Fly   897 KAKAMKMFSITKGKRVYRL-----------------REEFHDELEDRAYSSYEASRLAIQRNRTL 944

Mouse  1019 WEVASERAWTGGTESEMFNKLESIAMSDTPRTPVLGCCISRALE----PSVVQGEFITSRVNWVV 1079
            .||.....|.|||||.|||:||.||....||||.||..:|||||    |...| .|:.:|:||||
  Fly   945 AEVFHRPNWQGGTESAMFNRLEEIATGSQPRTPFLGGRLSRALEADTGPEQEQ-RFLPTRINWVV 1008

Mouse  1080 QSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAY 1144
            ||.|||:||||||:|:||.....   |||:|.|||:||||:||...:||||:.||||:||.....
  Fly  1009 QSGAVDFLHLMLVSMRWLMGSHV---RFCLSFHDELRYLVKEELSPKAALAMHITNLMTRSFCVS 1070

Mouse  1145 KLGLNDLPQSVAFFSAVDIDQCLRKEVTMDCKTPSNPTGMERRYGIPQGEALDIYQIIELTKGS 1208
            ::||.|||.||||||:|::|..||||.||||||||||.|:...|||..|::|.:.:.||...|:
  Fly  1071 RIGLQDLPMSVAFFSSVEVDTVLRKECTMDCKTPSNPHGLRIGYGIQPGQSLSVAEAIEKAGGN 1134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Polg	NP_059490.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..50		4/18 (22%)
		DnaQ_like_exo	<248..>280	CDD:299142	21/31 (68%)
		DNA_pol_A	413..>455	CDD:295402	24/41 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..523		11/39 (28%)
		DNA_pol_gammaA	763..1181	CDD:176478	233/424 (55%)
tam	NP_476821.1	DNA_pol_A	398..>440	CDD:295402	24/41 (59%)
		TRH	<420..539	CDD:283171	48/139 (35%)
		DNA_pol_gammaA	705..1107	CDD:176478	233/424 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847044
Domainoid	1	1.000	412	1.000	Domainoid score	I682
eggNOG	1	0.900	-	-		E1_COG0749
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2016
Inparanoid	1	1.050	904	1.000	Inparanoid score	I373
Isobase	1	0.950	-	0	Normalized mean entropy	S2606
OMA	1	1.010	-	-		QHG52013
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004939
OrthoInspector	1	1.000	-	-		oto91957
orthoMCL	1	0.900	-	-		OOG6_104329
Panther	1	1.100	-	-	LDO	PTHR10267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R347
SonicParanoid	1	1.000	-	-		X3481
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.780