DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pold1 and DNApol-zeta

DIOPT Version :9

Sequence 1:NP_035261.3 Gene:Pold1 / 18971 MGIID:97741 Length:1105 Species:Mus musculus
Sequence 2:NP_524881.2 Gene:DNApol-zeta / 47186 FlyBaseID:FBgn0002891 Length:2130 Species:Drosophila melanogaster


Alignment Length:1169 Identity:288/1169 - (24%)
Similarity:476/1169 - (40%) Gaps:237/1169 - (20%)


- Green bases have known domain annotations that are detailed below.


Mouse    37 LALLEEIEAENRLQE---AEEELQLPPEGTVGGQFSTADIDPRWRRPT--LRALDPSTEPLIFQQ 96
            ||:|:....|.:::|   .::.:.:.|          |.:.|.|:...  |:|     :.|:.|:
  Fly  1086 LAMLQRHRGEQKVREYFSTQQRIAIEP----------AQLAPTWQEAKIWLKA-----KELLRQR 1135

Mouse    97 LEIDHYVGSAPPLPEGPLPSRNSVPILRAFGVTDEGFSVCCHIQGFAPYFYTPAPPGFGAEHLSE 161
            .|                |.::|..|.....:..:..::.                         
  Fly  1136 EE----------------PKKSSDDIDSPIKIKRQKITMM------------------------- 1159

Mouse   162 LQQELNAAISRDQRGGKELS-----GPAVLAIELCSRESMFGYHGHGPSPFLRITLALPRLMAPA 221
            ||.|.....|.|:..|:||.     .|...|.:.|                 :.|....:.....
  Fly  1160 LQAEEGDGGSGDEDAGEELDCSLSLTPLSQAKDKC-----------------KATPTSSKARETG 1207

Mouse   222 RRLLEQGVRVPGLGT-----PSFAPYEANVDFEIRFMVDADIVGCNWLELPAGKYVRRAEKKATL 281
            :..|::|.|:..:|:     ||....|.:|.           ......||....::|:.|..:..
  Fly  1208 KSRLKRGTRLSFIGSQDEEPPSSQSSEQSVS-----------SSAAQAELDRSSFLRQLEGSSQD 1261

Mouse   282 CQLEVDVLWSDVISHPPEGQWQRIAPLRVLSFDIEC------------AGRKGIFPEPERDPVIQ 334
            .|.::....|........|....:..|:....||:|            :.|..:.|:|..|. |:
  Fly  1262 RQHDLSFGLSHATLDNTFGFKVNLENLQQAKADIDCNHLTIITLEVFVSTRGDLQPDPMHDE-IR 1325

Mouse   335 ICSLGLRWGEPEPFLRLALTLRPCAPIL------------------GAKVQSYEREEDLLQAWAD 381
            .....:....|:.    .|..:.|..|:                  ..:||....|.:..:|...
  Fly  1326 CLFYAIEHSLPDE----KLPSKACGYIMVNTVQDLLSEGPFHGIDRDIEVQVVTSEAEAFEALLA 1386

Mouse   382 FILAMDPDVITGYNIQNFDLPYLISRAQALKVDRFPFLGRVTGLRSNIRDSSFQSRQVGRRDSKV 446
            .....|.|:..||.|:.....|:|.||:.|..:..|.|.||.  ...:||...:.|:........
  Fly  1387 LCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRVP--TQKVRDFVDEDREQFTDLDVE 1449

Mouse   447 ISMVGRVQMDMLQVLLREHKLRSYTLNAVSFHFLGEQKEDVQHSI--ITDLQNGNEQTRRRLAVY 509
            :.:.||:.:|:.:::..|..|.|||...|.:|.|  .|....|:.  :|: ..|:..||..:..|
  Fly  1450 MKLCGRILLDVWRLMRSEIALTSYTFENVMYHIL--HKRCPWHTAKSLTE-WFGSPCTRWIVMEY 1511

Mouse   510 CLKDAFLPLRLLERLMVLVNNVEMARVTGVPLGYLLTRGQQVKVVSQLLRQAMRQGL--LMPVVK 572
            .|:.....|.||::|.:|....|||::.|:....:|:||.|.:|.|.:||.|..:.|  |.|.|:
  Fly  1512 YLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQ 1576

Mouse   573 TEG---SEDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGAAQKLG----- 629
            ...   :.:|. |.::||...:|..|:..|||.|||||:::|:|.|::|.|  |..:.||     
  Fly  1577 ARAHMRAPEYL-ALIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCL--GRVEHLGGSSPF 1638

Mouse   630 -----------------LKPDEFIKTPTGDEFVKSSVRKGLLPQILENLLSARKRAK--AELAQE 675
                             |:.|....:|.|..|||..||:|:||::|..:|..|:..|  .:|.::
  Fly  1639 EFGASQLRVSRQMLQKLLEHDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKD 1703

Mouse   676 TDPLRRQVLDGRQLALKVSANSVYGFTGAQV-GKLPCLEISQSVTGFGRQMIEKTKQLVESKYTV 739
            :..|:| :|..|||.||:.||..||:|.|.. |::|.:|:..||...||:.:|:..:|      |
  Fly  1704 SSALQR-ILHSRQLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSKGRETLERAIKL------V 1761

Mouse   740 ENGYDANAKVVYGDTDSVMCRFGVSSVAEAMSLGREAANWVSSHFPSPIRLEFEKVYFPYLLISK 804
            ||..:...:||||||||:.......:.|||..:|.|.|..|:...|.|::|:.||||.|.:|.:|
  Fly  1762 ENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTK 1826

Mouse   805 KRYAGLLFSSRSDAHDKMDCKGLEAVRRDNCPLVANLVTSSLRRILVDRDPDGAVAHAKDVISDL 869
            |||.|.::.:........:.||:|.||||.||.||.::...||.:...:|.....|:.....:.|
  Fly  1827 KRYVGYMYETADQEQPVYEAKGIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKL 1891

Mouse   870 LCNRIDISQLVITKELTRAAADYAGKQAH--------VELAERMRKRDPGSAPSLGDRVPYVIIG 926
            |..|.::..|:..||       :.|...:        :||..:..::||...|..|:|||::|:.
  Fly  1892 LSGRANLQDLIFAKE-------FRGLNGYKPTACVPALELTRKWMQKDPRHVPRRGERVPFIIVN 1949

Mouse   927 AAKGVAAYMKSEDPLFVL-EHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAESVLLRGDHTR-- 988
            ...|:........|..:| .....|:..||:.:.:..||.|            .:||.|.:..  
  Fly  1950 GPPGMQLIRLVRSPHDILANEGHKINAIYYITKAIIPPLNR------------CLLLIGANVHDW 2002

Mouse   989 -----CKTVLTSKVG-------------GLLAFTKRRNCCIGCRSVIDHQGAVCKFCQPRESELY 1035
                 .|.::|..||             .:..:....:|.|.|..  ..:..:|..|. :.:...
  Fly  2003 FASLPRKLLMTPAVGTANELAGARGAKSTISQYFSTTSCVIDCGR--QTKAGICPDCL-KNATTC 2064

Mouse  1036 QKEVSHLNALEERFSRLWTQ-CQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQE---RLLQ 1095
            ...:|...|..||..:|..| ||.|.|.| ..:.|.|.|||:.|:.:..|::|:..|   :||:
  Fly  2065 VVVLSDKTARLERGYQLTRQICQACCGRL-GSLQCDSLDCPVLYVLEGKRRELQQIEHWNKLLE 2127

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pold1NP_035261.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31
Nuclear localization signal. /evidence=ECO:0000255 4..19
PTZ00166 78..1098 CDD:240301 279/1125 (25%)
CysB motif 1056..1074 7/17 (41%)
DNApol-zetaNP_524881.2 PTZ00166 20..>196 CDD:240301
DNA_polB_zeta_exo 1297..1518 CDD:99821 50/230 (22%)
POLBc_zeta 1550..2000 CDD:99917 149/478 (31%)
zf-C4pol 2041..2107 CDD:405022 21/69 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0417
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001033
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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