DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phox2b and PHDP

DIOPT Version :9

Sequence 1:	NP_032914.1	Gene:	Phox2b / 18935	MGIID:	1100882	Length:	314	Species:	Mus musculus
Sequence 2:	NP_523834.1	Gene:	PHDP / 37788	FlyBaseID:	FBgn0025334	Length:	220	Species:	Drosophila melanogaster

Alignment Length:	180	Identity:	77/180 - (42%)
Similarity:	98/180 - (54%)	Gaps:	35/180 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 YSYLNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSLTPGSCSLGTL 70
            |:.:..|:|:.|         |:..|...|.:|.|...::.|.|.       ....|.:.::|:.
  Fly    42 YNLMIDSSYKLC---------ANESAIRGSLNQESSLLFSKITTV-------SEFYPATHNIGSY 90

Mouse    71 RD--HQSSPYAAVPYKLFTDHG-GLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELA 132
            ..  |         .|.:.|.| .|.:|.|||||||||||.||.|||::|.||||||||||||:|
  Fly    91 NTDFH---------LKSYGDDGLSLTDKSKQRRIRTTFTSNQLNELEKIFLETHYPDIYTREEIA 146

Mouse   133 LKIDLTEARVQVWFQNRRAKFRKQERAA-------AAAAAAAKNGSSGKK 175
            .|:.||||||||||||||||||||||.|       ::.....||..:|.|
  Fly   147 SKLHLTEARVQVWFQNRRAKFRKQERHAIYIMKDKSSKLDGRKNPVAGSK 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phox2b	NP_032914.1	Homeobox	102..155	CDD:395001	43/52 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..246		4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..289
PHDP	NP_523834.1	Homeobox	116..168	CDD:278475	42/51 (82%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6832
eggNOG	1	0.900	-	-		E1_KOG0494
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		otm42785
orthoMCL	1	0.900	-	-		OOG6_109475
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3133
SonicParanoid	1	1.000	-	-		X2223
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.700