Protein Alignment ECHS1 and CG4592

DIOPT Version :10

• Sequence 1: NP_004083.3
• Gene: ECHS1 / 1892
• HGNCID: 3151
• Length: 290
• Species: Homo sapiens
• Sequence 2: NP_609324.2
• Gene: CG4592 / 34317
• FlyBaseID: FBgn0032162
• Length: 287
• Species: Drosophila melanogaster
• Alignment Length: 294
• Identity: 74/294 - (25%)
• Similarity: 125/294 - (42%)
• Gaps: 48/294 - (16%)

Human    18 PVRC--PAWRPFASGANFEYIIAEKRGKNNTVGLIQLNRPKALNALCDGLIDELNQALKTFEEDP 80
            |:.|  .:.|..|:||..:....|...::. :..:.:|.| .:|.|...|:.:|..::...|.:.
  Fly    15 PILCGGQSLRSLANGATSKLTTIEVDDRSG-IATLSMNLP-PVNTLTMELMHDLIDSINQIESNK 77

Human    81 AVGAIVLTGGDKAFAAGADIKEMQNLSFQ--DCYSSKFLKHWDHLTQVKKPVIAAVNGYAFGGGC 143
            :.|.|:.:..||.|:||.|:.||.|...:  ..:.::|...|..|.....|..||:||::...||
  Fly    78 SRGLILTSSNDKVFSAGLDLNEMLNPDVERLRLFWTRFQDLWLALHLCGLPTAAAINGHSPAAGC 142

Human   144 ELAMMCDIIYAGEKAQFAQPEILIGTIPGAGGTQRLTRAVGKSL--AMEMVL----------TGD 196
            .||..|:.       :...|.:.||.     ...|.:..:.|.:  :.:.||          .|.
  Fly   143 VLATACEY-------RVMLPNLFIGI-----HATRFSFVISKWMMNSYQSVLPRRIVERALNQGK 195

Human   197 RISAQDAKQAGLVSKI-CPVETLVEEAIQCAEKIASNSK-------IVVAMAKESVNAAFEMTLT 253
            ..::|:|...|||.:| |..|   |...:||..||:..|       :...|.:|.  ...|:...
  Fly   196 LFASQEALDVGLVDEIACSKE---EALSKCAAFIATFDKTNPVARCLTKRMCREP--DVRELLQD 255

Human   254 EGSKLEKKLFYSTFATDDRKEGMTAFVE---KRK 284
            ..:.|::.:.|.|  |...:||:.|.:|   |||
  Fly   256 RAADLKECVDYVT--TPLFQEGLCAHLEGLKKRK 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ECHS1	NP_004083.3	crotonase-like	32..288	CDD:474030	68/278 (24%)
CG4592	NP_609324.2	crotonase-like	43..287	CDD:474030	65/264 (25%)