DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ECE1 and Nepl21

DIOPT Version :9

Sequence 1:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens
Sequence 2:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	712	Identity:	207/712 - (29%)
Similarity:	316/712 - (44%)	Gaps:	111/712 - (15%)

- Green bases have known domain annotations that are detailed below.

Human   116 TSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGH-SRWGTFSNLWEH-NQAIIKHLLENSTAS 178
            |:.|.|.||...|||:||::::||.:.:.|...... ...|.|..|.:. |:.|:|.|.....:.
  Fly    52 TAEIESFMDQKADPCNDFYAFSCGNYKRINSALSMQVVTTGVFETLTKGLNRKILKMLNTPHDSH 116

Human   179 VSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGP------WAKDNFQ--DTLQVV 235
            .:..:.|.:.:|.:|:....:....::.|..||...|    |.|      |.:|:|.  :|...:
  Fly   117 DTPEDIKVKHFYESCLQIKELNSTYSEKLKRLIAEFG----TMPLLEGSSWQEDDFDWLNTTARM 177

Human   236 TAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLN--------KTEN--EKVLTGYL 290
            ...|..:|.|.:.|:.|..::..|.|.:.|....|.:|..|::        |..|  :::|..||
  Fly   178 AYRYGITPIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMYVDDATAVYRQKYRNNIQRILQRYL 242

Human   291 NYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAIN 355
            ...:.|.|           ...::::|||..||...:.:.:..|...:...:|..|:|.     .
  Fly   243 GVKMDLAK-----------KTAKELIDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQR-----R 291

Human   356 WLPFLN---TIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNY----MIWNLVRKTSSF 413
            :.|.|:   .:|..:....|:.|..|:..|.:.:..:|..|.:..:.||    :||..|...|
  Fly   292 YSPTLDIDRLLFVSMGERISDQIYEYNNRYQQNLVEVIKRTPKRTVANYIFFRLIWEFVETPS-- 354

Human   414 LDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILE 478
                  |:.||.|              |.||..|:......|..||.:....|.|......:..:
  Fly   355 ------DSPEKQM--------------KACVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQ 399

Human   479 IKKAFEESLST---LKWMDEETRKSAKEKADAI---YNMIGYPNFIMDPKELDKVFNDYTAVPDL 537
            :|..|.|:|.:   |.|::..||..|..|..|:   .|.....||..:..||:...:||.
  Fly   400 LKSTFNETLRSSPALNWIERPTRNLAMAKLQAMTLEVNNYADDNFTEEFAELNLQSDDYV----- 459

Human   538 YFENAMRFFNFSWRVTADQLRKAPNR--------DQWSMTPPMVNAYYSPTKNEIVFPAGILQAP 594
              ||.    .::..:.|.|:|:..::        .|.|.||..:     ..:|.|..|..:|| |
  Fly   460 --ENV----RYTSLLGAKQMREMLHKPAKPFEAGSQLSYTPANI-----LIENTIKVPVALLQ-P 512

Human   595 FYTRSS--PKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQY 657
            ||..|.  |.|:.||.:..::||||.|.|||.||::|:.||.:.||...|...|.::.:|..:||
  Fly   513 FYIWSDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQY 577

Human   658 SNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKK-----NGAE----HSLPTLGLTNNQL 713
            ..|..:|..:.......||||||||::.||.||:.|.:.     |||:    .:||.|..|..||
  Fly   578 GRYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQL 642

Human   714 FFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKC 775
            ||:.|||.||:...|......:.||.|.|.||||||||||.:|||:.|.||.||.|||..||
  Fly   643 FFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKC 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	202/704 (29%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	202/701 (29%)
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	205/707 (29%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	200/699 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150954
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3745
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.900