DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ECE1 and Nepl20

DIOPT Version :9

Sequence 1:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens
Sequence 2:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster

Alignment Length:	713	Identity:	203/713 - (28%)
Similarity:	312/713 - (43%)	Gaps:	115/713 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   117 SSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGH-SRWGTFSNLWEH-NQAIIKHLLENSTASV 179
            :.|.|.|:..||||.||::::||.:.:.|...:.. ...|.|..|.:. |:.|:|.|  |:....
  Fly    46 AEIESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKML--NTPHDS 108

Human   180 SEAERKAQV--YYRACMNETRIEELRAKPLMELIERLGGWNITGP------WAKDNFQ--DTLQV 234
            .:.....||  :|.:|:....:....::.|..||...|    |.|      |.:|:|.  :|...
  Fly   109 HDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFG----TMPLLEGSSWQEDDFDWLNTTAR 169

Human   235 VTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVL--TGYL-NYMVQL 296
            :...|.......|.|:.|..|:..|:|.::|....|.:|..|:   :||..:  ..|. |..:.|
  Fly   170 MAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYM---DNETAIYRQNYQNNIQLIL 231

Human   297 GKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLN 361
            .|.||..||.| |...:::.:||..||:..:...|..:...:...:|.|||:.     .:.|.|:
  Fly   232 EKYLGVKDELA-RKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRE-----RYAPTLD 290

Human   362 T---IFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNY----MIWNLVRKTSSFLDQRFQ 419
            |   ||..:....|:.:..|::.|.:.:..:|..|.:..:.||    :||..::|.|...:
  Fly   291 TDQLIFVSMGEKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKPSGVAE---- 351

Human   420 DADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFE 484
                         |.|     :.||..|:......|..|..:....|.|......:..::|..|:
  Fly   352 -------------KPT-----EACVDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFK 398

Human   485 ESL---STLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF 546
            |:|   ..|.|::..||..|..|.:|:  .:...|::.:        |......||..:|.
  Fly   399 ETLLSSPALDWIEPSTRSLAIAKLEAM--TLEVNNYVKE--------NFTEEFADLNLQNT---- 449

Human   547 NFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTK------------------NEIVFPAGILQA 593
                 ...:.||:.    |......|...|:.|.|                  |.|..|..:||
  Fly   450 -----DCVENLRQV----QMLQAKQMRQLYHQPAKPLEAGELLSYTPSNILLENSIKVPVALLQ- 504

Human   594 PFYTRSS--PKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQ 656
            |||..|.  |.|:.||.:..::||||.|.|||.||::|:.||.:.||...|...|.::.:|..:|
  Fly   505 PFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQ 569

Human   657 YSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKK-----NGAE----HSLPTLGLTNNQ 712
            |..|..:|..:.......||||||||::.||.||:.|.:.     |||:    .:||.|..|..|
  Fly   570 YGRYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQ 634

Human   713 LFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKC 775
            |||:.|||.||:...|:.....:.||.|.|.:|||||:|||.:|||:.|.|..||.|||..||
  Fly   635 LFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKC 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	198/705 (28%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	200/703 (28%)
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	197/701 (28%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	198/701 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150955
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850