DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ECE1 and Nepl18

DIOPT Version :9

Sequence 1:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens
Sequence 2:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	704	Identity:	193/704 - (27%)
Similarity:	299/704 - (42%)	Gaps:	123/704 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   123 MDPTVDPCHDFFSYACGGWIKANPVP-DGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKA 186
            |.|.|.||.||:::|||.|.:.||.. .|......|..:.:.....::.||..:... ||.|:|.
  Fly    54 MKPEVSPCDDFYTHACGNWHRHNPAQLLGDVMTDNFKLISKGFDRRLQRLLRANDLQ-SELEKKM 117

Human   187 QVYYRACMNETRIEELRAKPLMELIERLGGWNITGP------WAKDNFQ--DTLQVVTAHYRTSP 243
            |.:|.:| |....:::..|..:|.:.|..|   |.|      |...:|.  .|:..:...|....
  Fly   118 QRFYMSC-NLVHRDDVHYKLALENVIREYG---TLPALVGAQWNSSDFSWWRTVAQIQHKYGKQI 178

Human   244 FFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI 308
            ...:.:..|.:|::.|.:              |:::.:.:.:.|...|.|            |.:
  Fly   179 IIGLEIMHDIRNTSVNRV--------------YISQPDFKTINTRLTNLM------------EEV 217

Human   309 RPQM--QQILDFETALANITIPQ--EKRR------------DEELIYHKVTAAELQ-TLAPAINW 356
            |..|  ||.....:::|..|..|  |..|            .|.|..:  |.|:|| ..:..:|:
  Fly   218 RTSMDLQQYFGLSSSVAKHTAEQLTELERTFSSGGSGAATLQESLSLY--TVADLQEKYSDHLNF 280

Human   357 LPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDA 421
            ..||..|.  .|.|..:.:.:||:|||::....:.:|......||::|.|       |:....||
  Fly   281 TEFLGLIL--GEENIPKSLYIYDEEYLDKALLTMRSTPLATQANYVLWKL-------LEDFLVDA 336

Human   422 DEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEES 486
            ..|.|.             |:|...|:...|........|.....|.:|...:|..:||..|.:.
  Fly   337 QPKDMV-------------KWCTESTKKYFGKLAEHAVYKRYRNPDVESEVHKIWDQIKGIFRQR 388

Human   487 L--STLKWMDEETRKSAKEKADAIY-NMIGYPNFIMDPKELDKVF--------NDYTAVPDLYFE 540
            |  ..|.|:...||..|.||.:.:: |:..|     |.:..:.|:        |..:.|..|...
  Fly   389 LLGDKLDWISNATRTLAIEKLERMHLNINSY-----DEENFENVYGEVFIDRLNYVSNVQQLLIA 448

Human   541 NAMRFFNFSWRVT--ADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAP-FYTRSSPK 602
            ..:||..   |:.  ||.:...   :....||.     |:..:|.|..|..:||.. |:....|:
  Fly   449 KGIRFVA---RINQPADSVDAT---ELLGFTPA-----YNIQENNITIPVALLQPRYFWGDQYPE 502

Human   603 ALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPV 667
            ||.:..:|.::.||:.|.|||.||:||..|||.|||...|...|:.:.:|...||..|...|..:
  Fly   503 ALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSKL 567

Human   668 NGRHTLGENIADNGGLKAAYRAYQNWVKKNGAE----HSLPTLGLTNNQLFFLGFAQVWCS---- 724
            .......|||||:||||.||.||:.|:.:...|    .::..|...:.||||||:||:.|.
  Fly   568 PESKDQSENIADSGGLKLAYAAYELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLCDDVQF 632

Human   725 VRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778
            :..|..|.    :|.|:||::||||.|||.:||...|.|...:||:|.:||.::
  Fly   633 LFQPWVSQ----SDRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	188/693 (27%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	190/696 (27%)
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	193/702 (27%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	189/695 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150956
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850