DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ECE1 and Nepl17

DIOPT Version :9

Sequence 1:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens
Sequence 2:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster

Alignment Length:	732	Identity:	185/732 - (25%)
Similarity:	310/732 - (42%)	Gaps:	98/732 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    79 VLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSS--ILSSMDPTVDPCHDFFSYACGGW 141
            ::.|.||.|.:|...  |:..:..:|   |.:..:.:..|  :.|.||.:|.||.||:.||||.:
  Fly    10 LIFVTLAVGSLAIQG--GVFKELTTP---LGQQIMRIAKSAEMCSFMDTSVSPCDDFYGYACGNY 69

Human   142 IKANPV---PDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSE-AERKAQVYYRACMNETRIEEL 202
            ...|..   .|.:.|...|:|....    ::.:|.....|... .|.:.:.:|.:|::...:...
  Fly    70 ATINAATSQKDTNIRQLMFANYLRR----VRQVLNEPRISTDRPMEVRVKYFYESCLDTAALRTK 130

Human   203 RAKPLMELIERLGG--------WNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSN 259
            :...|:.::...||        |:..|..|.:.....|:    .|.......|||..|..||...
  Fly   131 QRSHLLSVLREFGGMPAVEGKSWDYVGFDAIEMMAQLLR----RYGKLTLLGVYVVPDHFNSQIK 191

Human   260 VIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNY--MVQLGKLLGGGDEEAIRPQMQQILDFETAL 322
            .:|:.|.          |:..|:::..:.:..|  .::|..|| |..||..|...::|::.|..|
  Fly   192 RLQLGQR----------LDLAESDEFASLWKKYALKMRLRNLL-GLSEELARKTAEEIIELELEL 245

Human   323 ANITIPQEKRRDEELIYHKVTAAEL-QTLAPAINWLPFLNTIF---YPVEINESEPIVVYDKEYL 383
            :.........||..|:.|....:.: ....|.:|...|:.:..   |.:.:.||.|      .||
  Fly   246 SRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWLGSEYNLPVFESVP------SYL 304

Human   384 EQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTE 448
            .|:..::.:|...::.|||:       ||.|......|:|:..:|:      |..|......|..
  Fly   305 FQVKKILLSTPNHVVANYML-------SSLLTDFEITANEEQQKVI------CHERITELFPDVV 356

Human   449 NNLGFALGPMFVKATFAEDSKSIATE---IILEIKKAFEESLST--LKWMDEETRKSAKEKADAI 508
            :::        |..:..:.:..||.|   :.:|:|.:|.|.||:  ::|::::||:...||.:.:
  Fly   357 DHM--------VYHSLEQQNPYIANEMRSLWVELKSSFREMLSSPDIEWLEKQTREELLEKLNGM 413

Human   509 -YNMIG--YPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRV-TADQLRKAPNRDQW--- 566
             :.:.|  ..||       ::.|.|.......|:.|..|......|: ..|.||::.:...:
  Fly   414 SFEIAGGQAVNF-------EEQFGDLVVSSADYYGNIQRLLEVKARILRTDLLRESSSVYYYHGV 471

Human   567 SMTPPMVNAYYSPTKNEIVFPAGILQAPF-YTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDK 630
            :.||     .|....|.:|.|...:|..: :....|.||.:|.:|..:.||:.|.|||..|.||.
  Fly   472 TATP-----IYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFDDLNRLYDS 531

Human   631 DGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVK 695
            .|||...|...:...|:....|:.:|:|........:....:..|:||||.|::.|..||..|:.
  Fly   532 RGNLNDNWSTQTKVGFELVKNCLADQFSGMLYGNLRLRRLKSQAESIADNVGIRIAQSAYWKWLD 596

Human   696 KNGAE--HSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFS 758
            :...|  .|||.:..:..|||||..||..||...||.....:..:.|.|...||...:.||..|:
  Fly   597 QVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAMMINSPAFA 661

Human   759 EHFRCPPGSPMNPPHKC 775
            |.|:|...|.||||:||
  Fly   662 EAFQCSNSSKMNPPNKC 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	171/689 (25%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	173/682 (25%)
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	170/680 (25%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	171/680 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920