Protein Alignment ECE1 and Nep7

DIOPT Version :10

• Sequence 1: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Sequence 2: NP_651603.1
• Gene: Nep7 / 43356
• FlyBaseID: FBgn0039564
• Length: 717
• Species: Drosophila melanogaster
• Alignment Length: 743
• Identity: 202/743 - (27%)
• Similarity: 326/743 - (43%)
• Gaps: 170/743 - (22%)

Human   121 SSMDPTVDPCHDFFSYACGGW--IKANPVPDGHSRWGTFSNLWEHNQAII---KHLLENS----T 176
            |.|:.:||||.||:.:|||.|  :| .|....|.|    ||:.:.:..::   :.||..:    .
  Fly    60 SYMNFSVDPCDDFYEFACGNWKNVK-TPRQSPHRR----SNILDISYTLMDVTEQLLTRTKLAEA 119

Human   177 ASVSEAERKAQVYYRACMNETRIEELRAKP-LMELIERLGG--------WNITG-PWAKDNFQDT 231
            .:||.....||.:|.:|:.........|.| .:.:|..|||        ||.:. .|.  |....
  Fly   120 LNVSAELLVAQRFYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWF--NMSAH 182

Human   232 L----------QVVTAHYRTSPFFS--------VYVSADSKNSNSNVIQVDQSGLGLPSRDYYLN 278
            |          :.:...:..:|:|.        |..:|...|::|...|:::..:....::|.|.
  Fly   183 LSNYGVRSLIHEEILPQHPFNPYFKLPELGFDHVVHTAHVANTSSRAYQLNEHRMRGYLKEYNLT 247

Human   279 KTENEKVLTGYLNYMVQLGKLLGGGDE-EAIRPQMQQILDFETALANITIPQEKRRDEELIYHKV 342
            |.|...|:.|...:.   .:.|...|: |:.|.:...:.:.|      .:|   |..:...|:::
  Fly   248 KDEISAVIEGVFAFW---SEALSIEDKFESDRDKCDLLSEIE------EVP---RFGQWRSYYEI 300

Human   343 TAAELQTLAPAINWLPFLN-------TIFYPVEINESEPIVVYDK---EYLEQISTLINTTDRCL 397
                      |.|.:.|.|       ..||.||:         ||   ::.|.::
  Fly   301 ----------AWNGIDFYNGSSGGEFCDFYYVEL---------DKVCAKHTEAVA---------- 336

Human   398 LNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKA 462
              ||:....:.:....|.:..|..|:|.         .||    ..|..|..||   ...:::..
  Fly   337 --NYLAMRFLYRMDDKLKEPKQPEDQKV---------NCL----MIVQMTLPNL---FNRLYMAE 383

Human   463 TFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIG-YPNFIMDPKELD- 525
            .|.::..|..::::.|::||..:.|.:::|:|.|||..|..|...|..:|| |.|     :||.
  Fly   384 HFTDEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIGSYKN-----EELSD 443

Human   526 ---KVFNDYTAVPDLYFENAMRFFNFSWRVT-----------ADQLRKAPNRDQWSMTPPM---- 572
               :..|:.|.|...|.::.:..     ||.           ||:|.|.        |.|:
  Fly   444 TLIREINNLTIVEGSYAQSLINL-----RVLGTYLHRYAGLHADELPKD--------TKPLTLLV 495

Human   573 ---VNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 634
               |||:|....|.:...||:|..|.|.||.|.:|.||.||.::||||||.||.:|..:|..|.:
  Fly   496 GMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEV 560

Human   635 RPWWKNSSVEAFKRQTECMVEQYSNYSVN--GEPVNGRHTLGENIADNGGLKAAYRAYQNWVK-- 695
            |.||...|...|:.:.:|.|:.::.|.:.  .:.:.|..|..|||||.|||:||...|:|.:|
  Fly   561 RDWWSRKSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQL 625

Human   696 -KNGAE--------HSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 751
             ::||:        ..:|.|.|:..||||:||||:||:...||...|.| |..|:..::||:|::
  Fly   626 QRSGADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCADYEPEHYWEEL-TGAHTVDKYRVLGAV 689

Human   752 SNSKEFSEHFRCPPGSPMNP-PHKCEVW 778
            ||:.:|:|.::||.||||:| ...|.:|
  Fly   690 SNNDDFAEVYKCPLGSPMHPKAESCRMW 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	M13	127..776	CDD:341056	198/733 (27%)
Nep7	NP_651603.1	M13	66..715	CDD:341056	198/733 (27%)