DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ECE1 and Nep7

DIOPT Version :9

Sequence 1:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens
Sequence 2:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster

Alignment Length:	743	Identity:	202/743 - (27%)
Similarity:	326/743 - (43%)	Gaps:	170/743 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   121 SSMDPTVDPCHDFFSYACGGW--IKANPVPDGHSRWGTFSNLWEHNQAII---KHLLENS----T 176
            |.|:.:||||.||:.:|||.|  :| .|....|.|    ||:.:.:..::   :.||..:    .
  Fly    60 SYMNFSVDPCDDFYEFACGNWKNVK-TPRQSPHRR----SNILDISYTLMDVTEQLLTRTKLAEA 119

Human   177 ASVSEAERKAQVYYRACMNETRIEELRAKP-LMELIERLGG--------WNITG-PWAKDNFQDT 231
            .:||.....||.:|.:|:.........|.| .:.:|..|||        ||.:. .|.  |....
  Fly   120 LNVSAELLVAQRFYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWF--NMSAH 182

Human   232 L----------QVVTAHYRTSPFFS--------VYVSADSKNSNSNVIQVDQSGLGLPSRDYYLN 278
            |          :.:...:..:|:|.        |..:|...|::|...|:::..:....::|.|.
  Fly   183 LSNYGVRSLIHEEILPQHPFNPYFKLPELGFDHVVHTAHVANTSSRAYQLNEHRMRGYLKEYNLT 247

Human   279 KTENEKVLTGYLNYMVQLGKLLGGGDE-EAIRPQMQQILDFETALANITIPQEKRRDEELIYHKV 342
            |.|...|:.|...:.   .:.|...|: |:.|.:...:.:.|      .:|   |..:...|:::
  Fly   248 KDEISAVIEGVFAFW---SEALSIEDKFESDRDKCDLLSEIE------EVP---RFGQWRSYYEI 300

Human   343 TAAELQTLAPAINWLPFLN-------TIFYPVEINESEPIVVYDK---EYLEQISTLINTTDRCL 397
                      |.|.:.|.|       ..||.||:         ||   ::.|.::
  Fly   301 ----------AWNGIDFYNGSSGGEFCDFYYVEL---------DKVCAKHTEAVA---------- 336

Human   398 LNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKA 462
              ||:....:.:....|.:..|..|:|.         .||    ..|..|..||   ...:::..
  Fly   337 --NYLAMRFLYRMDDKLKEPKQPEDQKV---------NCL----MIVQMTLPNL---FNRLYMAE 383

Human   463 TFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIG-YPNFIMDPKELD- 525
            .|.::..|..::::.|::||..:.|.:::|:|.|||..|..|...|..:|| |.|     :||.
  Fly   384 HFTDEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIGSYKN-----EELSD 443

Human   526 ---KVFNDYTAVPDLYFENAMRFFNFSWRVT-----------ADQLRKAPNRDQWSMTPPM---- 572
               :..|:.|.|...|.::.:..     ||.           ||:|.|.        |.|:
  Fly   444 TLIREINNLTIVEGSYAQSLINL-----RVLGTYLHRYAGLHADELPKD--------TKPLTLLV 495

Human   573 ---VNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 634
               |||:|....|.:...||:|..|.|.||.|.:|.||.||.::||||||.||.:|..:|..|.:
  Fly   496 GMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEV 560

Human   635 RPWWKNSSVEAFKRQTECMVEQYSNYSVN--GEPVNGRHTLGENIADNGGLKAAYRAYQNWVK-- 695
            |.||...|...|:.:.:|.|:.::.|.:.  .:.:.|..|..|||||.|||:||...|:|.:|
  Fly   561 RDWWSRKSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQL 625

Human   696 -KNGAE--------HSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 751
             ::||:        ..:|.|.|:..||||:||||:||:...||...|.| |..|:..::||:|::
  Fly   626 QRSGADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCADYEPEHYWEEL-TGAHTVDKYRVLGAV 689

Human   752 SNSKEFSEHFRCPPGSPMNP-PHKCEVW 778
            ||:.:|:|.::||.||||:| ...|.:|
  Fly   690 SNNDDFAEVYKCPLGSPMHPKAESCRMW 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	197/731 (27%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	198/733 (27%)
Nep7	NP_651603.1	PepO	60..717	CDD:226118	201/741 (27%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	198/733 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150957
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850