DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ECE1 and Nep5

DIOPT Version :9

Sequence 1:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens
Sequence 2:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster

Alignment Length:	830	Identity:	240/830 - (28%)
Similarity:	396/830 - (47%)	Gaps:	131/830 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    50 PN--GLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEAC 112
            ||  |:|..|      :|.:..:..:...|.::::||.|.:|   .:||::   :|.|:|.|:.|
  Fly    83 PNLIGIQSKF------RRSYYHKVVLGGLLALVIILLIAIIV---ISLGLK---KSSSICRSKEC 135

Human   113 VSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLL-ENST 176
            :...:|::.:||...|||.||:.:.||.|...:|.||..:....|.....|...:::..| .|.|
  Fly   136 LRTAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVREFLRSNIT 200

Human   177 ASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLG------GWNIT----GPWA------K 225
            .|..||..||:..|||||:...:::...:||:..:.|.|      ..|:|    ..:|      |
  Fly   201 KSEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYLLRFGLPVLPSALNLTLGSGSKYATEAANVK 265

Human   226 DNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD--YYLNKTENEKVL-- 286
            .|:..::..:..|..........|..|..|...|.|     .||.|..|  :..|..::.|:|
  Fly   266 YNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRTINRI-----ALGTPETDSAFPFNNDDSHKMLRK 325

Human   287 ------------------------------------TGYLNYMVQ-LGKLL-----GGGDEEA-- 307
                                                |.||:|:.: :.|.|     ....|||
  Fly   326 IHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVNQEEATL 390

Human   308 -IRPQMQQ-------ILDFETALANITIPQEKRRDEELIYHKVTAAELQ-----TLAPAI--NWL 357
             |...::|       :.:|:....|:|.|.:...| :::|  :|..:||     .:||..  .|:
  Fly   391 GITELVKQGVRVARKVHEFKEEAENMTKPSKNPAD-DIVY--ITLQDLQNQTDKNIAPKTLPIWV 452

Human   358 PFLNTIFY------PVEINESEPIVV--YDKEYLEQISTLINTTDRCLLNNYM----IWNLVRKT 410
            .::..|..      .:::.::..|:.  .|..||:.|...::.|....:.:|:    |..||..|
  Fly   453 RYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLSTIEELVLHT 517

Human   411 SSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEI 475
            ||.:    :....::|.|..||:.: .||..:|.:...:.||.|:..:...|.|.::.......:
  Fly   518 SSSM----RLLHSEYMRVAIGTEGS-TPRSLYCANGVNSLLGMAVSYVLADADFTKEKLPKVERM 577

Human   476 ILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFE 540
            :.:|:::|:..:.:..|||..|::...:|:..:.:.||:|.::.:...|:..:.........:.|
  Fly   578 LSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAEVNASTHLE 642

Human   541 NAMRFFNFSWRVTADQLRK--APNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKA 603
            |.|.|.:  |:: .|:|.:  .|....|:.:|..|||:::...|.|..|..|||.|||.... :|
  Fly   643 NLMDFVH--WQM-MDKLNEMDKPEPIGWATSPSNVNAFHTFQSNAITVPIAILQYPFYDLGL-EA 703

Human   604 LNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVN--GEP 666
            ||:|.||.::||||||.|||.||.:|:.||:..||.|.:::.:..:|||.|||||.|.:.  .|.
  Fly   704 LNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRYHLADIDEY 768

Human   667 VNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHS-LPTL-GLTNNQLFFLGFAQVWCSVRTPE 729
            ::|..|||||||||||::.|:.||:.:||:.|.|.| ||.| ..::.||||:.|..:||...||.
  Fly   769 IDGELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLPGLEHYSHEQLFFISFGNLWCETYTPA 833

Human   730 SSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPH-KCEVW 778
            :|...| ||.|.|.:.|:.|.||||:||:..|:|..|:||||.. ||.:|
  Fly   834 ASRYAL-TDSHCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	215/752 (29%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	217/747 (29%)
Nep5	NP_733186.2	PepO	146..882	CDD:226118	220/753 (29%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	217/746 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920