Protein Alignment ECE1 and Nepl16

DIOPT Version :10

• Sequence 1: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Sequence 2: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Alignment Length: 869
• Identity: 172/869 - (19%)
• Similarity: 294/869 - (33%)
• Gaps: 280/869 - (32%)

Human    20 PRGSNSMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRS-----GQRCWA----ARTQ--V 73
            |.||..|     ...||.:::||.:         ..||::..:     |..|.|    .||.  |
  Fly    52 PVGSKQM-----GKSDEIEMIDSAN---------IENFNTRYNKNSIIGWICCAPCIWLRTSAAV 102

Human    74 EKRLVVLVVLLAAGLVA-------------------------CLAALGIQYQTRSPSVCLSEACV 113
            .|..:....||...|:.                         |..|:.      :|..|....|.
  Fly   103 HKMAITSATLLVTTLLVASPILFLISTAPSPLPRDCYMDGDRCSPAVS------APPECSDPICE 161

Human   114 SVTSSILSSMDPTVDPCHDFFSYACGGWIK------ANPVPDGHSR------------------- 153
            :|.|||.:.::...|||.:|..::|  |..      .|.:..|:|:
  Fly   162 AVASSIQARLNWNKDPCTEFKKFSC--WRNTPNKNITNLIEMGNSQKSVDSQMLYLFQNKIMNGS 224

Human   154 WGTFSNLWEH------NQAIIKHLLEN--------STASVSEAERKAQVYYRACMNETRIEELRA 204
            :|...||:|.      |..::..:.::        |....|.|...|::|           :|..
  Fly   225 FGILHNLFESCLQQTTNSTVMHRIFDSLGGYLPVGSVGPSSIAPLIAKIY-----------DLGP 278

Human   205 KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSN------------ 257
            .||::|...|.                       |...|...:.:|..|.:|.
  Fly   279 SPLVDLYHDLS-----------------------YGRRPHILLIISGPSTSSTILERKIRWMSPK 320

Human   258 ---SNVIQVDQSGLGLPSRDYYLNKTENEKVLT----GYLNYMVQLGKLLGGGDEEAIRPQMQQI 315
               |.:.|      |:|            |:|.    .:|.|.|...:.:...|         .|
  Fly   321 APPSRIRQ------GVP------------KLLADLIENFLPYFVSYAQRVSEKD---------TI 358

Human   316 LDFETALANITIPQEKRR--DEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVY 378
            .:|...|..:.:...:|.  |..::|:   .:.||.|.|.:||     |:..|.  |.|.||||.
  Fly   359 FEFIKDLNKLQVEHSRRGFWDSTVLYN---VSSLQDLYPVLNW-----TLLIPQ--NWSGPIVVR 413

Human   379 DKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFC 443
            :.:||:.:...:......:.:|.:   |:......|.:.:                   |..:.|
  Fly   414 NSDYLKALEYFLTKYPTRVAHNSL---LLLSALQILPRDY-------------------PSPEVC 456

Human   444 VSDTENNLGFALGPMFVKATFAEDSKSIA--TEIILEIKKAFEESLSTLKWMDEETRKSAKEKAD 506
            ...|...|......:::....:||.|...  .|||.:..||..:...:||       .:|..|..
  Fly   457 TRSTMWALPELSSSLYIAQHSSEDLKDTTKRAEIIFKSLKAHLKRAPSLK-------GAALVKLS 514

Human   507 AI----YNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWS 567
            |:    ....|:.|    ..:|.|.........:.:|:|.:..:..:.....|......:.|.|:
  Fly   515 ALKIQSQTWEGFSN----TTDLLKSLQPLNITSECWFQNILEIYKKNKLEPNDISLNGGSHDAWA 575

Human   568 MTPPMVNA-YYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHE----LTHAFDDQGRE 627
            .  |:|:. :|....:.||.|..::..|::....|..|::..:||.:..|    :|.:||:
  Fly   576 Y--PIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEILRSITKSFDE---- 634

Human   628 YDKDGNLRPWWKNSSVEAFKRQTECM---VEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRA 689
                                :...|:   |..:||||        |..:   :..:||::.:|.:
  Fly   635 --------------------KAMRCVPHSVNIFSNYS--------RMDI---LIHSGGMQISYHS 668

Human   690 YQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL-SN 753
            ..:..........||.|.||..|:|||..||..|:    ||::.|:  |.::|....::|.| :.
  Fly   669 MLSLTGPIKGMARLPGLNLTPTQIFFLVSAQELCA----ESNYLGI--DTNAPEFDNILGWLVAQ 727

Human   754 SKEFSEHFRCPPGSPMNPPHKCEV 777
            ....:|.|:||.||.:|....|.|
  Fly   728 GGSATEVFKCPSGSMINVQKTCNV 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	M13	127..776	CDD:341056	141/723 (20%)
Nepl16	NP_001097912.1	GluZincin	176..750	CDD:472708	141/722 (20%)