Protein Alignment ECE1 and Nepl13

DIOPT Version :10

• Sequence 1: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Sequence 2: NP_651096.1
• Gene: Nepl13 / 42699
• FlyBaseID: FBgn0039022
• Length: 741
• Species: Drosophila melanogaster
• Alignment Length: 765
• Identity: 179/765 - (23%)
• Similarity: 293/765 - (38%)
• Gaps: 180/765 - (23%)

Human   115 VTSSILSSMDPTVDPCHDFFSYACGGW------------------------------IKANPVPD 149
            :.:.:...|:.:.|||.|||.||||.|                              :...|:|.
  Fly    56 IATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQPLPP 120

Human   150 GHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERL 214
            .|                  |....|.||::.. ||.:.:|.:|:........|.:.||::::..
  Fly   121 QH------------------HPNGYSGASMTNV-RKVRAFYESCVAVEANASERRRFLMKILKDN 166

Human   215 GG--------WNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGL--- 268
            ||        |.....|.:     ||..:..:|.......:.:..:.:....|.|...:..|
  Fly   167 GGLRNVPNSNWQHNRQWVQ-----TLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTII 226

Human   269 -----------GLPSRD--YYL---NKTENEKVLTG------------YLNYMVQLGKLLGGGD- 304
                       |...||  |.|   ..|||.:...|            .:.:..:|.|.:|..|
  Fly   227 PAEHCNALATRGAQVRDEVYELVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQDI 291

Human   305 ---EEAIRPQMQQILDFETALANITIPQEKRRDEELIYHK--VTAAELQTLAPAINWLPFLNTIF 364
               ||...|.:|         |.|...:.:...|.|...|  :|..||  .:...|.|.|...:.
  Fly   292 QKPEEEFPPAIQ---------AQIYGARSRTGQERLRRQKGGMTLTEL--TSEMGNHLDFKMLVE 345

Human   365 YPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVM 429
            ..:|......:.:...||::.:...:...:|..:..|:::..:.:    |:|..::|..:
  Fly   346 VILESQYPSQVYLRSPEYVKHVVRTVKANNRITVGGYILYVALNE----LNQPPEEAPSQ----- 401

Human   430 YGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMD 494
                     |.:.||..|:......||.||.:....:::|.....:..::.||.||... ::|||
  Fly   402 ---------RARQCVQVTQRLFPQVLGEMFQRHVQRDNAKHDLDAVFNDVIKALEEQFH-VEWMD 456

Human   495 EETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRK 559
            |..|::|:.:      :..|...:.|.:.||        :.||.|:.:..:    ||.....|:.
  Fly   457 ENDRRAARTR------LSQYRVSLPDYQSLD--------LTDLQFQKSEDY----WRRLEIALKY 503

Human   560 APN------------RDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVV 612
            ..:            :|...:....|.|..||.:..::...|:||||:|....||:|.:..:|..
  Fly   504 RSHQQFEALRGNDFGQDADGLDAFEVRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHR 568

Human   613 VGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHT--LGE 675
            :...|..||||:|  ::........|...::..::..:||...|||:|..| ||...|:.  |.|
  Fly   569 LASALVQAFDDEG--WNNHPQATAQWNEVTMSGYRNASECQRAQYSSYLYN-EPGEFRNATRLRE 630

Human   676 NIADNGGLKAAYRAYQNWVKKNG-------AEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHE 733
            .|||..||..|:.||..|:::..       |:.:|..|..||.||||:.|||..|..:    .::
  Fly   631 IIADGSGLNLAFNAYLAWLEQQDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAK----DNQ 691

Human   734 GLITD-----PHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778
            ..|.|     .|:|.|:.|.|.||||.||...|.|..|:|||...||.|:
  Fly   692 DAILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	M13	127..776	CDD:341056	176/749 (23%)
Nepl13	NP_651096.1	M13	68..738	CDD:341056	175/748 (23%)