Protein Alignment ECE1 and Nep4

DIOPT Version :10

• Sequence 1: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Sequence 2: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Alignment Length: 972
• Identity: 313/972 - (32%)
• Similarity: 460/972 - (47%)
• Gaps: 204/972 - (20%)

Human     5 IIRNAGYKCKFHCPHPRGSNSMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRS------- 62
            |:|..|..........|..:..:::....:..||....|.||..|.:.:...|..|.|
  Fly    75 IMRLDGMLAALQLNEQRMRDLRNSHSEVPVYMEDYEALLPEGSTYNDLINEEFILPASKRTQLQI 139

Human    63 -----GQRCWAAR------TQVEKRLVVL----VVLLAAGLV-ACLAALGIQ------------- 98
                 .:||...|      .::|:|..::    ...|..|:. .||.: ||:
  Fly   140 LAAERARRCQPYRYGNGESMELEERNTLMKDSRTSFLPLGIPRECLGS-GIELDIKPIDEEAYQR 203

Human    99 ----YQTRSP---------------------SVCLSEACVSVTS-----------------SILS 121
                ||..:|                     |..:|||..::.|                 ::..
  Fly   204 QKKRYQDIAPYWLEKIRIRERREAERHAEEASAEISEATAALQSFWNEEGTREGIRMTQAKTMKR 268

Human   122 SMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENST---------- 176
            .||..||||.||:.||||.|.:.:|:|...:.:.||..|.|....::::|||.:|
  Fly   269 YMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRK 333

Human   177 ----------------------ASVSEAER----------------------------------- 184
                                  |:...|||
  Fly   334 SPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETP 398

Human   185 ---------------------------------------------KAQVYYRACMNETRIEELRA 204
                                                         ||:..||:|:|...:.:...
  Fly   399 RERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGL 463

Human   205 KPLMELIERLGGWNI-TGPWAKDNFQ-DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG 267
            :||..||..||||.: ...|::.||. ..|......|........:|.||.|||..|::|.||:|
  Fly   464 EPLHTLIRELGGWPVLESQWSESNFNWQVLAATLRRYNNDILIVQWVGADIKNSEENIVQFDQTG 528

Human   268 LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKR 332
            ||||:|:|:| :..|.|.|..|..||.::...:|....:|.| ...:::.|||.||.||.|.|:|
  Fly   529 LGLPTREYFL-QPSNAKYLQAYQRYMAEVMHKMGASKADAQR-VASELVAFETQLAGITAPAEQR 591

Human   333 RDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCL 397
            .:...:|.::|..:||.:.|.|.|..:|.:: ...|:..:|.:|:|..||:.::.||::.||...
  Fly   592 LNVTKLYKRMTLDQLQAVVPEIKWRAYLQSL-QDREVLGTEEVVIYAVEYMSKLVTLLDETDPRT 655

Human   398 LNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLP-RWKFCVSDTENNLGFALGPMFVK 461
            ::|||:|..||...:.:|.||.|..:.|...::|.:::  | |||.|::....|:|.|:|.|||.
  Fly   656 VSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREES--PQRWKVCIAQVNTNMGMAVGSMFVS 718

Human   462 ATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDK 526
            ..|..:||.....:..::::||.:.|.|..|:|:.|::.|:||.:|:...||||:||::|.||:.
  Fly   719 RYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFILNPSELNS 783

Human   527 VFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGIL 591
            .:......|:.||||.:.....:.:....:|.:..|:..|...|.:||||||..||:|:||||||
  Fly   784 KYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQIMFPAGIL 848

Human   592 QAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQ 656
            |.|||.|..||:|||||||||:||||||.|||:||.:|::||:..||.:||:..|..:..|::.|
  Fly   849 QPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQ 913

Human   657 YSNYSVN--GEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHS---LPTLGLTNNQLFFL 716
            ||||:|.  |..:||..|.||||||||||:.|:.|||.|:|::.:|.|   ||.|.:|..|||||
  Fly   914 YSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFL 978

Human   717 GFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778
            .|.||||....||:....|.|..|||.||||||:||||.:|:..|.||.||||||..||.||
  Fly   979 NFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	M13	127..776	CDD:341056	276/768 (36%)
Nep4	NP_650904.3	M13	274..1038	CDD:341056	276/768 (36%)