Protein Alignment ECE1 and Nep2

DIOPT Version :10

• Sequence 1: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Sequence 2: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Alignment Length: 777
• Identity: 280/777 - (36%)
• Similarity: 420/777 - (54%)
• Gaps: 78/777 - (10%)

Human    67 WAARTQVEKRLVV----LVVLLAAGLVACLAALGIQYQTRSPS---------------------- 105
            |..|.::||.|:|    :.|:||.|....   :|...:|..||
  Fly    11 WRRRNKLEKSLLVSLGIMFVVLATGFGLW---IGKVLRTSPPSNPQATALHGDSTTINQVPTGTA 72

Human   106 ----------VCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNL 160
                      |||::.|:...|::|..|.|.|:||.:|:.:|||.:::...:||......|||.:
  Fly    73 SKGKSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVI 137

Human   161 WEHNQAIIKHLLENSTASVSEAE----RKAQVYYRACMNETRIEELRAKPLMELIERLGGWNIT- 220
            .:..|..:|.::   ||...|.|    |...:.|:||||:|.||.|..:|:..:.||||||.:.
  Fly   138 SDKLQEQLKDII---TAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIK 199

Human   221 -GPW-AKDNFQDTLQVVTAHYRTSPFFSVY-----VSADSKNSNSNVIQVDQSGLGLPSRDYYLN 278
             ..| |.|::  |.|.....:||:.|...|     :..|.:||...:|.:|||.|.| ||: ||.
  Fly   200 GDSWNADDSW--TWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL-SRE-YLV 260

Human   279 KTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 343
            |..||.::|.|..|||.:. :|.|.:.:..:.::...|:||.|||||:.|.||||:...:|:..|
  Fly   261 KGFNETLVTAYYKYMVDIA-VLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRT 324

Human   344 AAELQTLAPAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNL 406
            .|:||...|.:.|:.::|.:. |..:|  |.|.|.:....:.|.:..|:..|.:.::.|||.|.:
  Fly   325 PAQLQAAYPYVQWVDYMNALL-PEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRI 388

Human   407 VRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCV-----------SDTENNLGFALGPMFV 460
            ...:..||.:.|:....::...:.|.::. ..|||.||           .|..::||.::|.::|
  Fly   389 HGFSVGFLSEEFRKRQLQYATALSGRQEQ-EARWKECVDIATSSMDEVCEDDFDSLGISVGSLYV 452

Human   461 KATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELD 525
            ...|.:|||:.|.|::.||:..|.:.|..:.|||.:|:|.||.|..::...||||:.::|.::|.
  Fly   453 GKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLA 517

Human   526 KVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQW--SMTPPMVNAYYSPTKNEIVFPA 588
            ..:......||.|||:.:....|....:.::||...|:..|  ...|.:|||:||..:|.|.|||
  Fly   518 AYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPA 582

Human   589 GILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECM 653
            ||||..|:....||.:|||.||.|:|||:||.||||||::|..||||.||...:.:|:..:.:|:
  Fly   583 GILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCI 647

Human   654 VEQYSNYS--VNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFL 716
            :|||.||:  ..|..:||.:|.|||||||||:|.:|.||:.|.:|:|.|..||.|..|..|:|::
  Fly   648 IEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMFWV 712

Human   717 GFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778
            ...|.||:....||....:.|..||||.|||:|||||.|:|::.|.||.||||||..|||||
  Fly   713 AAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	M13	127..776	CDD:341056	254/677 (38%)
Nep2	NP_001246914.1	M13	104..772	CDD:341056	254/677 (38%)