DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ECE1 and Nepl11

DIOPT Version :9

Sequence 1:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens
Sequence 2:	NP_649449.1	Gene:	Nepl11 / 40540	FlyBaseID:	FBgn0037230	Length:	592	Species:	Drosophila melanogaster

Alignment Length:	740	Identity:	147/740 - (19%)
Similarity:	260/740 - (35%)	Gaps:	218/740 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    89 VACLAALGIQYQTRSPSVCLSEACVSVTSSILS---SMDPTVD----PCHDFFSYACGGWIKANP 146
            :|.|...||.|.        .:..:.|.:.:||   :::|.:|    ||.||:.|.|..  .||.
  Fly     6 LAVLWIAGIAYG--------QDDLLRVETELLSFSHNLEPYLDTSKQPCQDFYGYVCSH--SANL 60

Human   147 VPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELI 211
            ...|..|:          |:::|   |...|.:.:.|.:...::::|.:...:|.|:..   :|.
  Fly    61 SETGRQRF----------QSLLK---ETDVAQLMDMELQLINFFKSCESGRGVEALKGS---QLY 109

Human   212 ERLGGWNITGPWAKDNFQDTLQVVT-------AHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLG 269
            .:.|||....|...:..|.|.|...       .|...:|:|  :.::.:..||..::.:...|
  Fly   110 RQSGGWPSLEPNKVNASQRTNQTQRWLGLLGYFHEVGAPYF--FETSVTMQSNKRLVVLQPDG-- 170

Human   270 LPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRD 334
              :|...|.|.|.            ::|::|.....|..|..:       |||..::: :..|||
  Fly   171 --TRRNTLRKFEQ------------RVGEVLQSFGIEQSRAHV-------TALEVLSL-ERSRRD 213

Human   335 ------------------EELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKE 381
                              :.:::...:...|       :|..:...:........|:.|||....
  Fly   214 IVKADHVEDQVQFSYGNFKRIVFGNASLIRL-------DWDGYFRKLLGGKTPQASDTIVVKQLP 271

Human   382 YLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSD 446
            .|.:...|:..|....|.|: ||     |...:|  ..|||                    |...
  Fly   272 RLVEYFALLQNTSMVRLLNW-IW-----TDYLMD--IVDAD--------------------CHQL 308

Human   447 TENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAK--------- 502
            :|...|.....:..:.|   .::....::..|:.||:.:.|....|:||.:|:|::
  Fly   309 SETYAGDLYAHVVQRVT---ANRVELAQMYSELGKAYTDQLGGSVWIDEISRQSSRQFLGNIMHT 370

Human   503 -----EKADAIYN--MIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKA 560
                 |:.||.|:  ::|..:...:.::|.|            |:...|..:.|    |.|:|:.
  Fly   371 TLNGDERLDAAYHSILLGRRSLYRNLEKLRK------------FQRTRRLASHS----AQQVRRY 419

Human   561 PNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQG 625
            .     .|..| |||:...                :..|:|  ||:    :::|...:.:....|
  Fly   420 A-----QMFAP-VNAFLGQ----------------HNLSTP--LNY----LLLGEFFSRSLVAAG 456

Human   626 REYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAY 690
            ......|   .|..:.|...|....:|:          |:..|....|...:|.    :.|..||
  Fly   457 SSSRTQG---AWRSSDSERRFAIFQQCV----------GKQTNAIDLLLSLLAQ----RQALSAY 504

Human   691 QNW-------VKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVI 748
            ..|       |::..|..:..:..::..:|||:....|.|      .|..|.:    ...|.|.:
  Fly   505 GQWLATQAGLVERVDAVLAAGSSKMSLQRLFFVTSLLVDC------RSELGAL----QQDRKRQV 559

Human   749 --GSLSNSKEFSEHFRCPPGSPMNP 771
              .:|.||.||.|.|||.||..:.|
  Fly   560 THATLRNSPEFLEAFRCRPGDVLYP 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	141/711 (20%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	138/699 (20%)
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	137/693 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810