DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ECE1 and Nepl10

DIOPT Version :9

Sequence 1:XP_011539174.1 Gene:ECE1 / 1889 HGNCID:3146 Length:778 Species:Homo sapiens
Sequence 2:NP_610787.1 Gene:Nepl10 / 36366 FlyBaseID:FBgn0033742 Length:633 Species:Drosophila melanogaster


Alignment Length:762 Identity:173/762 - (22%)
Similarity:274/762 - (35%) Gaps:220/762 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    88 LVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHS 152
            |.:||.||.|      |...:.:..|:.::.|.::::.|..||.:|:::|||.:..|:...|...
  Fly     7 LCSCLVALFI------PIQAIVDINVATSNDIHNNLNRTTSPCTNFWNFACGRFSSASKYVDNFE 65

Human   153 R----WGTFSNLWEHNQAIIK----HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLME 209
            |    :.|         |:::    ||.||.|.:....::..| ||:||..:||  :|...|..|
  Fly    66 RVEDQFAT---------AMVEFMESHLGENDTLAPRLIKQMRQ-YYKACKEDTR--KLHGNPRPE 118

Human   210 LIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPS-R 273
              |.:..| |..|          :....:.....|....|...:.:|...|||     |.:|. .
  Fly   119 --ELVNQW-ILHP----------KKFLVYGLNGVFIDERVDVAANDSMRWVIQ-----LRMPDPA 165

Human   274 DYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEA--------IRPQMQQILDFETALANITIPQE 330
            |.|.::.            ::||.:|.    |||        :..:|.|:             |:
  Fly   166 DRYSDRR------------VLQLMRLY----EEAWYSMGVVKLVEKMHQL-------------QD 201

Human   331 KRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYP-VEINESEPIV-----VYDKEYLEQISTL 389
            |.|.|..:.:..:.:||:      ..:|..::.|.. :.:|.:|.:.     |.|.|||.:..  
  Fly   202 KYRAEYPVVYTWSFSELR------QEIPIPHSFFIELLGVNHTEELYHLTFEVSDVEYLRECF-- 258

Human   390 INTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRW---KFCVSDTENNL 451
                 |||                .|...:..|.......|...:...||.   :.|:......|
  Fly   259 -----RCL----------------RDFASEPKDTYIRARQYVLVEESEPRERNPRSCIHHMRAYL 302

Human   452 GFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLK-----WMDEETRK-------SAKEK 504
              .||..::...|...::...|..:|||       |||||     ::|....:       ..:.|
  Fly   303 --PLGMNYIYDRFIYQNREEDTSKVLEI-------LSTLKAAFGQYLDANRLQLTPNQLAYVRAK 358

Human   505 ADAIYNMIGYPNFIMDPKELDKVF--NDYTAV---PDLYFENAMRFFNFSWRV------------ 552
            .:.|...||  |.   |:|....|  |.|.:.   ...:..|.:..|....|:            
  Fly   359 LEGIQIKIG--NL---PEEKSPEFYNNHYGSANFSATNFLANLLEAFALRTRLQNAGLLARNSRV 418

Human   553 ------TADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGV 611
                  ..|.:|||       .|.|    :|...:|.|..|...||.|.:............:|.
  Fly   419 DLRHYYVNDNVRKA-------RTSP----FYENERNTITVPMEFLQWPLFDHREHTIFQHSLLGA 472

Human   612 VVGHELTHAFDDQGREYDKDGNLRP-WWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGE 675
            |:|||:.|||:.:|..:|..||..| ..:....:.|:...:|..||         |.   .:|.|
  Fly   473 VLGHEMNHAFEQEGILFDAAGNESPVGLEIRESKPFRDAIKCAEEQ---------PF---VSLKE 525

Human   676 NIADNGGLKAAYRAYQNWVKKNGAEHSLPTL---------GLTNNQLFFLGFAQVWCSVRTPESS 731
            .:||..||:.||.|:      .|..|.....         ..|..|||.|.:||.:|....|..:
  Fly   526 RLADLNGLQLAYDAF------FGLAHDSRQFEYRPYAFEQEFTAPQLFHLSYAQFFCGSLPPVIA 584

Human   732 HEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778
            |:   .|..     ||..|:.|.::|:..|.|    ..:|...||:|
  Fly   585 HD---RDDE-----RVNVSVGNLRQFAYDFNC----ETSPSSVCEMW 619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ECE1XP_011539174.1 PepO 114..769 CDD:226118 161/725 (22%)
M13 127..776 CDD:189000 160/719 (22%)
Nepl10NP_610787.1 GluZincin 41..608 CDD:301352 158/705 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG3590
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D282463at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11733
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

Return to query results.
Submit another query.