Protein Alignment ECE1 and Nepl10

DIOPT Version :10

• Sequence 1: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Sequence 2: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Alignment Length: 762
• Identity: 173/762 - (22%)
• Similarity: 274/762 - (35%)
• Gaps: 220/762 - (28%)

Human    88 LVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHS 152
            |.:||.||.|      |...:.:..|:.::.|.::::.|..||.:|:::|||.:..|:...|...
  Fly     7 LCSCLVALFI------PIQAIVDINVATSNDIHNNLNRTTSPCTNFWNFACGRFSSASKYVDNFE 65

Human   153 R----WGTFSNLWEHNQAIIK----HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLME 209
            |    :.|         |:::    ||.||.|.:....::..| ||:||..:||  :|...|..|
  Fly    66 RVEDQFAT---------AMVEFMESHLGENDTLAPRLIKQMRQ-YYKACKEDTR--KLHGNPRPE 118

Human   210 LIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPS-R 273
              |.:..| |..|          :....:.....|....|...:.:|...|||     |.:|. .
  Fly   119 --ELVNQW-ILHP----------KKFLVYGLNGVFIDERVDVAANDSMRWVIQ-----LRMPDPA 165

Human   274 DYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEA--------IRPQMQQILDFETALANITIPQE 330
            |.|.::.            ::||.:|.    |||        :..:|.|:             |:
  Fly   166 DRYSDRR------------VLQLMRLY----EEAWYSMGVVKLVEKMHQL-------------QD 201

Human   331 KRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYP-VEINESEPIV-----VYDKEYLEQISTL 389
            |.|.|..:.:..:.:||:      ..:|..::.|.. :.:|.:|.:.     |.|.|||.:..
  Fly   202 KYRAEYPVVYTWSFSELR------QEIPIPHSFFIELLGVNHTEELYHLTFEVSDVEYLRECF-- 258

Human   390 INTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRW---KFCVSDTENNL 451
                 |||                .|...:..|.......|...:...||.   :.|:......|
  Fly   259 -----RCL----------------RDFASEPKDTYIRARQYVLVEESEPRERNPRSCIHHMRAYL 302

Human   452 GFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLK-----WMDEETRK-------SAKEK 504
              .||..::...|...::...|..:|||       |||||     ::|....:       ..:.|
  Fly   303 --PLGMNYIYDRFIYQNREEDTSKVLEI-------LSTLKAAFGQYLDANRLQLTPNQLAYVRAK 358

Human   505 ADAIYNMIGYPNFIMDPKELDKVF--NDYTAV---PDLYFENAMRFFNFSWRV------------ 552
            .:.|...||  |.   |:|....|  |.|.:.   ...:..|.:..|....|:
  Fly   359 LEGIQIKIG--NL---PEEKSPEFYNNHYGSANFSATNFLANLLEAFALRTRLQNAGLLARNSRV 418

Human   553 ------TADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGV 611
                  ..|.:|||       .|.|    :|...:|.|..|...||.|.:............:|.
  Fly   419 DLRHYYVNDNVRKA-------RTSP----FYENERNTITVPMEFLQWPLFDHREHTIFQHSLLGA 472

Human   612 VVGHELTHAFDDQGREYDKDGNLRP-WWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGE 675
            |:|||:.|||:.:|..:|..||..| ..:....:.|:...:|..||         |.   .:|.|
  Fly   473 VLGHEMNHAFEQEGILFDAAGNESPVGLEIRESKPFRDAIKCAEEQ---------PF---VSLKE 525

Human   676 NIADNGGLKAAYRAYQNWVKKNGAEHSLPTL---------GLTNNQLFFLGFAQVWCSVRTPESS 731
            .:||..||:.||.|:      .|..|.....         ..|..|||.|.:||.:|....|..:
  Fly   526 RLADLNGLQLAYDAF------FGLAHDSRQFEYRPYAFEQEFTAPQLFHLSYAQFFCGSLPPVIA 584

Human   732 HEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778
            |:   .|..     ||..|:.|.::|:..|.|    ..:|...||:|
  Fly   585 HD---RDDE-----RVNVSVGNLRQFAYDFNC----ETSPSSVCEMW 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	M13	127..776	CDD:341056	160/719 (22%)
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	158/705 (22%)