Protein Alignment ECE1 and Nepl7

DIOPT Version :10

• Sequence 1: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Sequence 2: NP_609577.2
• Gene: Nepl7 / 34671
• FlyBaseID: FBgn0032442
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 709
• Identity: 204/709 - (28%)
• Similarity: 312/709 - (44%)
• Gaps: 132/709 - (18%)

Human   119 ILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHN-QAIIKHLLENSTA----- 177
            :||:|:.|:|||.:|:.::||||.||:.||: .:|..:|.|..:|. ...|:..|:|:|.
  Fly    44 LLSTMNRTIDPCENFYEFSCGGWKKADLVPE-QARNTSFLNAIQHKIDEQIQGFLQNATKRELED 107

Human   178 ----SVSEAERKAQVYYRACMNETRIEELRAKPLMELI-ERLGGWNITGPWAKDNFQD-----TL 232
                ..:.||.||:.:|.:|:.......|..:..||.. :||...|.|..|...||..     .|
  Fly   108 LGVNGTTSAEIKAKQFYASCVEMKANLSLGYQYFMEHDGDRLKERNATYDWMYINFMSKYDIYPL 172

Human   233 QVVTAHYRTSP-FFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKT--------ENEKVLTG 288
            ..:..||.||. .|.:.::..||    .:....:..|...:|::.|:.:        ||...||.
  Fly   173 LALKVHYSTSSRKFDILLTLPSK----VLAGFSEEQLKNMTREFGLDSSAEKVKQFVENFNNLTQ 233

Human   289 YLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPA 353
            :...:|.|.|         .|.:.:| |:|:               |.|:.||         ...
  Fly   234 FERNLVSLAK---------SRNETEQ-LNFK---------------EFLVKHK---------HDR 264

Human   354 INWLPFLNTIF-------YPVEINESEPI--VVYDKEYLEQISTLINTTD-----RCLLNNYMIW 404
            :||..|....|       :|| :|:.:.|  :|:   :|||  |.:.|..     |.|:..|.:|
  Fly   265 LNWTRFFELAFNGSQESHWPV-LNQLDNINDLVF---FLEQ--TNLETLKGYIKMRELVKFYGLW 323

Human   405 NLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSK 469
            ....||.....:                          |.|.:|....:||.|.|:...|.::.:
  Fly   324 KTQTKTGGVQSE--------------------------CRSLSETYFNYALLPWFIGKVFDKERR 362

Human   470 SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAV 534
            :....:..:||..|.:.|....|:||:||..||.|..::..::||.:.:...:.:|.|::|....
  Fly   363 ADILSVAKDIKDTFYDLLDHHTWLDEDTRSQAKTKLASMDILVGYTDDLQHREVIDGVYSDINMT 427

Human   535 PDLYFENAMRFFNFSWRVTADQLRKA------PNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQA 593
            .: :|||.........|:....:.||      |.|        .|||||:...|......|:.|.
  Fly   428 GN-WFENLCILEGSRARIRLRSVDKALIPLLMPTR--------TVNAYYADFLNLAFITIGMAQW 483

Human   594 PFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYS 658
            |||....|..|.:.|:|.::|||:.|.||....:|:.||....||.::|:..||.:..|:..||:
  Fly   484 PFYHIDFPDVLKYAGVGNIIGHEMAHGFDSYCYQYNYDGKKTNWWSSASLRNFKERYRCLESQYN 548

Human   659 NYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNG----AEHSLPTLGLTNNQLFFLGFA 719
            .:.:.|...||..|.|:|||||.|.:.||.|::   :|.|    .|..|..:...|.||||:.||
  Fly   549 KFILMGVQTNGSLTSGDNIADNVGTRMAYYAFK---RKTGDKAWLEKPLRGVNFNNKQLFFVKFA 610

Human   720 QVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778
            |.||:.:........|.||.|:...|||.|:|||..||||.|.|..|:.|||..||.||
  Fly   611 QTWCNGKDNGDKLRRLKTDVHAYDEFRVQGTLSNMPEFSEAFNCKLGTEMNPLKKCVVW 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	M13	127..776	CDD:341056	197/697 (28%)
Nepl7	NP_609577.2	M13	52..666	CDD:341056	196/696 (28%)