Protein Alignment ECE1 and Nepl6

DIOPT Version :10

• Sequence 1: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Sequence 2: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Alignment Length: 751
• Identity: 183/751 - (24%)
• Similarity: 301/751 - (40%)
• Gaps: 158/751 - (21%)

Human    88 LVACLAALGIQYQTRSPSVCLSEACVS--VTSSILSSMDPTVDPCHDFFSYACGGWI---KANPV 147
            |:|||..:.|   ..:|:....||..:  :.::|||.:......|..:|.||||.:.   :.:|.
  Fly     3 LIACLFIVPI---CAAPTTQNVEADPNSRLMNNILSYVAEDSSACGTYFQYACGKYAVRHRDDPF 64

Human   148 PDGHSRWGTFSNLWEH----NQAIIKHLLENSTAS----VSEAERKAQVYYRACMN---ETRIEE 201
            .:       ...:.:|    |...:.|.|...:.|    .|..|.|...:||.|..   .||..|
  Fly    65 TE-------IIQMLDHKVNGNLVQLMHELHQRSQSPGFNESSVEAKVLHFYRTCREAPPSTRKME 122

Human   202 --LRAKPLMELIERLGGWNIT--------GPWAKDNFQDTLQVVTAHYR---TSPFFSVYVSADS 253
              ||..|        .|..:|        .||.|..|: .::.:...||   |:...:|.|...|
  Fly   123 HYLRLAP--------PGQALTWPQFMPRGEPWPKAQFK-WMKSLGHLYRYGFTNVLVNVLVLRSS 178

Human   254 KNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDF 318
            :|||.  .::|   :.:||.:      .:.:.|.|:|:.:..|..:  |...::|.|.:::|...
  Fly   179 ENSNR--FRLD---ISMPSLE------GDAQHLGGFLSTLATLQII--GVPTKSILPLVRKIRRL 230

Human   319 ETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVV--YDKE 381
            |:|:..:|   |...|:|.....:...|.:|   ...|..|:.:|   |..:.|...|:  .:.:
  Fly   231 ESAIRVLT---EVDDDDESETWTLRQWEYKT---GYAWQGFVESI---VGHSVSHHYVMQAQNAK 286

Human   382 YLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSD 446
            |...:..|:::||..::.||::...|    .:|...|.|::|..                .||:|
  Fly   287 YFTGLKRLMDSTDAEVVANYIMTRFV----LYLIDDFIDSNEHI----------------DCVTD 331

Human   447 TENNLGFALGPMFVK-----ATFAEDSKSIATEIILEIKKAF--EESLSTLKWMDEETRKSAKEK 504
            ...|:..|...::.:     ||..:.::.: |::..::::.|  :.:.:.|....|:....|.:.
  Fly   332 MRRNMNLASNLLYKERFLDPATLQQYTQEV-TKVFEQLRRQFLLQINENRLGLTSEQNSMVATKA 395

Human   505 ADAIYNMIGYP------NFIMDPKELDKVFNDYTAVPDL-YFENAMRFFNFSWRVTADQL-RKAP 561
            ...:.|:...|      :|:....| |.||    .:||. |....:....|..|....|| :.||
  Fly   396 QHVVLNIGNLPRGRDHRSFVSRHYE-DLVF----PLPDFDYAREHLNLLEFRTRKQVLQLNQSAP 455

Human   562 NRDQW-----SMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAF 621
            ..|::     ..|......||....|.||.|.|:||.||:...|.....:..:|.|:.|||.|:.
  Fly   456 TPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAHELMHSV 520

Human   622 DDQGREYDKDGNLR---PWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGL 683
            |..|..||:.||:.   |  :.||...|....:|:....:.|            |.|.|||..||
  Fly   521 DTVGLYYDRYGNIHEIGP--QISSSPRFVAGLQCLNRNSTQY------------LDERIADIAGL 571

Human   684 KAAYRAYQNWVKKNGAEHSLPTL-GLTNNQLFFLGFAQVWCSVRTPESSHEGLITDP-----HSP 742
            ..||..|    .:|.::.||... .:...|:|||..||.:|.        :|   ||     |..
  Fly   572 DLAYSTY----FQNSSQMSLTDFTTIPPQQIFFLNLAQFFCG--------DG---DPINFVGHDN 621

Human   743 SRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778
            ...|:...|:....|.|.|.||..|  |.|.||::|
  Fly   622 DETRLQQMLNGFAPFHEAFGCPAKS--NQPEKCQLW 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	M13	127..776	CDD:341056	170/706 (24%)
Nepl6	NP_609023.3	M13	47..653	CDD:341056	169/700 (24%)