DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ECE1 and Nepl5

DIOPT Version :9

Sequence 1:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens
Sequence 2:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster

Alignment Length:	775	Identity:	177/775 - (22%)
Similarity:	304/775 - (39%)	Gaps:	170/775 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    83 LLAAGLVACLAALGIQYQTRSPSVC-LSEACVSV----TSSILSSMDPTVDPCHDFFSYACGGW- 141
            :|...|||.| ...:.::| :|:.| .:.|..||    ...:.|.||....||.:|:.||||.|
  Fly     1 MLKLSLVAWL-IFSLAWRT-TPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQ 63

Human   142 IKANPVPDGHS----RW--------GTF-----SNLWEHN-----QAIIKHLLENSTASVSEAER 184
            |:..   :.||    .|        |..     ..|.:|:     :.:::...|:|..|.|....
  Fly    64 IQQQ---EQHSLRDRDWTRDRQRYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSILE 125

Human   185 KAQVYYRACMNETRIEELRAKPLMELIERLGG--WNITG-PWAKDNFQ--DTLQVVTAHYRTSPF 244
            :.::|||:|   .|::....|..::|:.....  |...| .|..:.|.  .||..:..|
  Fly   126 QMRLYYRSC---KRLKPYNLKKYLQLLPPSNSTQWPSVGRGWRPERFDWITTLGRLRLH------ 181

Human   245 FSVYVSADSKNSNSNVIQVDQSGLGLP----SRDY--YLNKTENEKVLTGYLNYMVQLGKLLG-G 302
                      ..|..:::.:.    ||    ||:|  |:||...::........|::|  ||. |
  Fly   182 ----------GLNGVLLREEV----LPRWDDSRNYSIYVNKPSRQETQPMGEGAMIEL--LLDIG 230

Human   303 GDEEAIRPQMQQILDFETALANITIPQEKRRDE-----ELIYHKVTAAELQTLAPAINWLPFLNT 362
            ..:.......:|:.|||..|..:   ||...||     :|.|       |.:..|.:.||.|:..
  Fly   231 QTKRTANALARQVDDFERKLHRL---QELEDDEGPREMQLGY-------LDSYLPQLRWLSFMRQ 285

Human   363 IFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFME 427
            :....|::....:::.:..||..:|.|:.:.....:.:|    ::.|..:||.|: ..||....|
  Fly   286 VRIDSELDLRSTLIIENIPYLRALSDLMESESPDTVCSY----IMLKWLAFLKQQ-GPADISRGE 345

Human   428 VMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAE-DSKSIATEIILEIKKAFEESLSTLK 491
                           ||:.....:..| ....|...|:: :|:|..:.:...:|..|.:.|:
  Fly   346 ---------------CVAALRRAMPLA-SSWLVGQQFSDPESESYVSSLFQRLKVRFGQILA--- 391

Human   492 WMDEETRKS------AKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVP--------------- 535
              :...|.|      .::|..|:...:|:    ...:|::.|...:..:.
  Fly   392 --ENRMRLSPPLVHILQQKLRAVRLQMGF----FQTEEIEDVEQYHVRIDLSGHSFYGNQLVLLR 450

Human   536 -------DLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQA 593
                   ||.:.|...|.|    .|...|.......:.|.:.|:   |..| :|.::.|.|:||.
  Fly   451 QRVEANHDLLYINVTNFAN----STGSNLSYLSESWEASNSSPL---YVRP-RNLVLVPHGLLQL 507

Human   594 PFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLR-PWWKNSSVEAFKRQTECMVEQY 657
            |.:.|:.........:|.|:.|||.|.||..|.:||..||:. |..:..:...|::..:|:.:|.
  Fly   508 PIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQM 572

Human   658 SNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQN-WVKKNGAEHSLPTLGLTNNQLFFLGFAQV 721
            :         .|...:.|.:||...|:.||..:.. ..|:...:..||.  .:..||||:.|||.
  Fly   573 A---------TGSKWIDEKLADFVALRLAYETFFGVRDKREPRDPLLPQ--FSQRQLFFITFAQF 626

Human   722 WCS---VRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778
            :|.   |.:|.|..|..:  .|:....||:.:|:|.:|||..|.|...:.|....:|.:|
  Fly   627 FCGRTPVLSPRSQSEAHL--KHAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	165/732 (23%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	161/722 (22%)
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	165/730 (23%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	161/722 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920