DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ECE1 and Nepl4

DIOPT Version :9

Sequence 1:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens
Sequence 2:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	786	Identity:	158/786 - (20%)
Similarity:	280/786 - (35%)	Gaps:	207/786 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    64 QRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTS-----SILSSM 123
            |..|.|             ||..|...|.:::.::......|......|.|..:     :::|.:
  Fly     3 QNLWTA-------------LLLLGSATCGSSVPVKANDPEQSCPYLGECNSTINQQHIDTLMSYV 54

Human   124 DPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHN-----QAIIKHLLENSTASVSEAE 183
            |...:||.||::||||.| :|.     |....|.:.:.|..     :.:...||.|.:|......
  Fly    55 DSEKNPCEDFYAYACGKW-RAK-----HGSHTTATMISESQINRQYEDLFLQLLRNPSAPEYGYP 113

Human   184 RKAQV--YYRAC--------------MNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTL 232
            ..|:|  :|::|              ::...:..|.:...|.|:..||.:...|.:.:
  Fly   114 MFAKVLAHYQSCIALEKPDLRRYIELLDRDLLASLNSTHWMHLLAALGRYGYHGHYVQ------- 171

Human   233 QVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLG 297
              |...:..:....:::...:::.|.::.|           |.|...:::
  Fly   172 --VEVRWYNATHHMIFLLPHNRHLNLSLTQ-----------DIYDALSQD--------------- 208

Human   298 KLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNT 362
                |.....:....:|....|..|..:..|..  .|:  .:...:..:::|..|.::|...|.|
  Fly   209 ----GSSWPPLHQLQEQFRSLEQNLVRLAKPHS--ADD--TFRNYSLDQIRTEVPGLHWDEALRT 265

Human   363 IFYPVEINESEP----IVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADE 423
                 ::..|.|    ..|.|.:.:|.:...:||.|..|||.|   :|.|..|..|:
  Fly   266 -----QLGRSVPGNHVFQVDDLDAIEGLVEYLNTVDTLLLNRY---SLARFLSHLLE-------- 314

Human   424 KFMEVMYGTKKTCLP-------------RWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEI 475
                         ||             |.:.|:.....::...:..::.::.::.  :..|.|:
  Fly   315 -------------LPHNPLATWESGQRSRGRNCIRHMRRSVYLPMNYVYERSFYSR--RRHADEL 364

Human   476 ILEIKKAFEESLSTLKW--------MDEETRKSAKEKADAIYNMIGY--PN----FIMDPKELDK 526
            :  |...|::..|.|:.        :.::..||.:.|...:...:|.  ||    |..|......
  Fly   365 V--IHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRINVGNLPPNVTEQFYWDSDRRWS 427

Human   527 VFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPN---RDQW----SMTPPM-----VNAYYSP 579
            |..|       ::||.:....:.:.:.|| |..:.:   ||.|    ..||..     ...|:..
  Fly   428 VGRD-------FYENHLNSLLYYYTLVAD-LESSSDQEERDIWYSFNMHTPEFPDNIDATPYFYC 484

Human   580 TKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKN-SSV 643
            ..|.|..|...::.||:..:...||.:|.:...:|||:.||||....:||..||||.:... ..|
  Fly   485 LGNIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYDAQGNLRNFSDQLGEV 549

Human   644 EAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAY-QNWVKKNGAEHSLPTLG 707
            |.:.....|:         |...|    .|.|..:|..|.:.|.:.| .:|:.::|
  Fly   550 ELYNGAVGCL---------NSSAV----MLNERTSDVSGSRLAMQTYGGDWLTRSG--------- 592

Human   708 LTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPP 772
              |.:|:||.||..:|       ..||  ...|.....|:..:|....:|:|.|||..||.|...
  Fly   593 --NGRLYFLQFAHFFC-------GDEG--DQYHDSGSQRLNYALGQVPQFAEVFRCHVGSGMTSA 646

Human   773 HKCEVW 778
            .:|..|
  Fly   647 DQCPFW 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	146/725 (20%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	144/714 (20%)
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	145/714 (20%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	144/712 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920