DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ECE1 and Nep3

DIOPT Version :9

Sequence 1:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens
Sequence 2:	NP_001245775.1	Gene:	Nep3 / 33005	FlyBaseID:	FBgn0031081	Length:	786	Species:	Drosophila melanogaster

Alignment Length:	799	Identity:	348/799 - (43%)
Similarity:	498/799 - (62%)	Gaps:	59/799 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    26 MSTYKRATLDEEDLVD----SLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAA 86
            |:.||:....|:|...    .|:|...: .|:|:.:|:.|:... |.:|.:.||.|::...::|.
  Fly     1 MTRYKQTEFTEDDSSSIGGIQLNEATGH-TGMQIRYHTARATWN-WRSRNKTEKWLLITTFVMAI 63

Human    87 GLVACLA--------------ALGIQ-YQTRSPS----VCLSEACVSVTSSILSSMDPTVDPCHD 132
            .:...|.              .|.:| :|...||    .||::.|:..:|.||.|:|.|||||.|
  Fly    64 TIFTLLIVLFTDGGSSDATKHVLHVQPHQKDCPSGNELPCLNKHCIFASSEILKSIDVTVDPCDD 128

Human   133 FFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASV-SEAERKAQVYYRACMN- 195
            |:.|:|..|||.||:|:|.|.||||..|.:.||.||:::||....|. |:|||||:|||.:|::
  Fly   129 FYGYSCNQWIKNNPIPEGKSTWGTFGKLEQMNQLIIRNVLEKPAKSFKSDAERKAKVYYESCLDA 193

Human   196 ETRIEELRAKPLMELIERLGGWNIT------GPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSK 254
            :..:|:|.|||:.:|:.::||||:|      ..|...:   ||:::...|..:..|...:..|.|
  Fly   194 DEHMEKLGAKPMNDLLLQIGGWNVTKSGYNVANWTMGH---TLKILHNKYNFNCLFGWAIGEDDK 255

Human   255 NSNSNVIQVDQSGLGLPSRDYYLNKTEN-EKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDF 318
            ||:.:|||:||.||.||:.|||.|||:| .|||..|:.||.::..|||..:.:| |.||..:::|
  Fly   256 NSSRHVIQIDQGGLTLPTADYYNNKTDNHRKVLNEYIEYMTKVCVLLGANESDA-RAQMIGVINF 319

Human   319 ETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPV--EINESEPIVVYDKE 381
            |..|||||||.|.||:||.:||.:...:|..|||.:||....:.....|  .:.:.|.:|||..:
  Fly   320 EKKLANITIPLEDRRNEEAMYHPMQLRQLSKLAPFLNWTDHFDNAMQMVGRRVTDDEVVVVYAPD 384

Human   382 YLEQISTLI-----NTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPR-- 439
            :|:.:|.:|     ....:..||||::|..||..:|.|.:.|:||.:       |.:|..:..
  Fly   385 FLKNLSDIILKMEQTEEGKITLNNYLVWQAVRTLTSCLSKPFRDAYK-------GVRKALMGSDG 442

Human   440 ----WKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKS 500
                |::|||||.|.:|||:|.:||:..|..:||..|.::|.||::||:.:|..|.|:|::||:.
  Fly   443 GEEIWRYCVSDTNNVVGFAVGAIFVRQAFHGESKPAAEQMIAEIREAFKMNLQNLTWVDKQTREK 507

Human   501 AKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQ 565
            |.|||:.|.:|||:|::|:||.||||.:.:....|:.||||.::...::.:....:|.:..|:..
  Fly   508 AIEKANQISDMIGFPDYILDPVELDKKYAELNITPNAYFENNIQVAIYNLKSNLKRLDQPVNKTN 572

Human   566 WSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDK 630
            |.|||..|||||:||||:|||||||||.||:..::||:||||.:|||:|||||||||||||||||
  Fly   573 WGMTPQTVNAYYTPTKNQIVFPAGILQTPFFDINNPKSLNFGAMGVVMGHELTHAFDDQGREYDK 637

Human   631 DGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVK 695
            .||:..||.:.|:|.|..::||:..|||.|.:||..:||:.||||||||||||||||.|||....
  Fly   638 FGNINRWWDSKSIERFNEKSECIARQYSGYKMNGRTLNGKQTLGENIADNGGLKAAYHAYQRTKS 702

Human   696 KNGAE-HSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSE 759
            ....: ..||.|.||::||||:.|||||||..|.|::...:..||||||:|||||:|||.|||:|
  Fly   703 DRDVDILKLPGLNLTHSQLFFVSFAQVWCSSTTDETNLLQMEKDPHSPSQFRVIGTLSNMKEFAE 767

Human   760 HFRCPPGSPMNPPHKCEVW 778
            .|:|.||..|||..|||||
  Fly   768 VFQCKPGKRMNPTEKCEVW 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	314/677 (46%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	312/671 (46%)
Nep3	NP_001245775.1	M13	123..784	CDD:189000	312/671 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150959
Domainoid	1	1.000	312	1.000	Domainoid score	I1308
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1068
Inparanoid	1	1.050	657	1.000	Inparanoid score	I779
Isobase	1	0.950	-	0	Normalized mean entropy	S3745
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	1	1.000	-	-		FOG0000538
OrthoInspector	1	1.000	-	-		otm40479
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2675
SonicParanoid	1	1.000	-	-		X1744
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750