DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ECE1 and Nep6

DIOPT Version :9

Sequence 1:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens
Sequence 2:	NP_001245645.1	Gene:	Nep6 / 32234	FlyBaseID:	FBgn0030425	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	766	Identity:	181/766 - (23%)
Similarity:	299/766 - (39%)	Gaps:	188/766 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    80 LVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKA 144
            |||:|...|:...||...|.|                  :.:..|..|.||.:|..||||.|...
  Fly    11 LVVILGVMLLKLAAAQDCQQQ------------------LDNDTDAEVKPCENFHQYACGNWYSN 57

Human   145 NP-----VPDGHSRWGTFSNLWEHNQAIIKHLLENST-------ASVSEAERKAQVYYRACM--- 194
            ..     ..|..|:|  .:||   ...:|::|.|:|:       .||:.:..:....||.|:
  Fly    58 TSQRILGAHDMRSKW--VANL---KLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYRCCLLSG 117

Human   195 --NETRIEELRAK----PLMELIERLGG---WNIT----------GPW---AKDNFQDTLQVVTA 237
              ..|..:.|...    ||  |....||   |.:.          |.|   .|||:|...|.:
  Fly   118 QSIRTYTDALSRSGANFPL--LANHTGGSFDWVLANAALRTYGAQGLWRLLVKDNWQSADQRI-- 178

Human   238 HYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENE---KVLTGYLNYMVQLGKL 299
            .|...|.|.:                    ||   ||..||:...:   |:|...|...|:...|
  Fly   179 FYMLPPKFDL--------------------LG---RDDELNEFLYQRYLKILLLELGLRVRRAAL 220

Human   300 LGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHK-VTAAELQTLAPAINWLPFLNTI 363
            |.           ::::.||.:|..: :|.:  .::.|:..| .:..:|::..|.:....:..||
  Fly   221 LA-----------EKLVAFEKSLQKL-LPND--AEQTLVLRKPQSLKDLESQLPRLELKRYFETI 271

Human   364 FYPVEINESEPIVVYDKEYLEQISTLI--NTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFM 426
            ...::.:....::|.|.:||:.:..|:  :|:|..:|:.:::..|    .::.:.|..|.|:
  Fly   272 LEGIDWDSKTLLLVADLDYLQGLQRLLAEHTSDPMVLSTWLLLQL----PAYFELRLHDDDK--- 329

Human   427 EVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEI-------KKAFE 484
               .|.::      ..|:......:...||.:.::....|..:.:....|.:|       |:.||
  Fly   330 ---LGNQR------NHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLFRDLKQQFE 385

Human   485 ESLSTLKWMDEE--TRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDL-------YFE 540
            ..|:..:..:|:  ||..|::|..|:.        ::.|:..|.: |.....|.|       ..:
  Fly   386 LVLNETEVFNEDLVTRNLARDKLRAMR--------LLTPRLQDPI-NGGPGTPQLGGNCDANLLQ 441

Human   541 NAMRFFNFSWR-VTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPK-- 602
            .::......:| |..:.:...|      ..|..|||||....|.|..|.|::..|...:...|
  Fly   442 LSLSQAKLEYRQVFGEPVTSVP------ADPLSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEA 500

Human   603 ---ALNFGGIGVVVGHELTHAFDDQGREYDKDGNL-RPWWKNSSVEAFKRQTECMV-EQYSNYSV 662
               |....|:|.::.||:.||||..|..||..|.| ...|...::..|..:..|.: .:|||.::
  Fly   501 DTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCYLGVRYSNATL 565

Human   663 NGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRT 727
                     |:.|||||..||:.|...|::   ::||         ||.:.||:.|||.||..
  Fly   566 ---------TVNENIADTEGLRLALDTYRH---RSGA---------TNLRTFFVAFAQNWCGT-- 607

Human   728 PESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778
             .:|..||  ..|:....||...:.|..||.:.|.|...|.|||.:||.:|
  Fly   608 -VASTSGL--SQHAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	166/721 (23%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	169/715 (24%)
Nep6	NP_001245645.1	PepO	35..655	CDD:226118	171/722 (24%)
Nep6	NP_001245645.1	M13	40..653	CDD:189000	169/715 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920