Protein Alignment ECE1 and Nep1

DIOPT Version :10

• Sequence 1: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Sequence 2: NP_511056.2
• Gene: Nep1 / 31547
• FlyBaseID: FBgn0029843
• Length: 849
• Species: Drosophila melanogaster
• Alignment Length: 1259
• Identity: 244/1259 - (19%)
• Similarity: 409/1259 - (32%)
• Gaps: 433/1259 - (34%)

Human    69 ECLMFESGAVAVLSSA-----EKEAIKGTYAKVLDAYGLLGVLRLNL-GDTMLHYLVLVTGCMSV 127
            ||...:.|.|...||:     .|...:...:.|:....:..:.|.:| |...|..|||....:.:
  Fly    26 ECTCDKKGLVVDCSSSGLTRIPKNISRNVRSLVIRNNRIHKLKRSDLEGFNQLETLVLTHNKIKI 90

Human   128 GKIQESEVFRVTSTEFISLRVD--------ASDEDRISEVRKVLNSGNF-------YFAWSASGV 177
              |:|:.:..:...:.:||..:        .||...::.:....|...|       ||   ....
  Fly    91 --IEENVLDHLPELKRLSLAHNELVYIPPLCSDSRPLASLNLKRNHIQFIDEQVLRYF---PDLT 150

Human   178 SLDLSLNAHRSMQEHTTDNRFFWNQSL-HLHLKHYGVNCD-------------DWLLRLMC-GGV 227
            .||.|.|..:|::....||.    .:| |.||.....:||             .|..::.| ..|
  Fly   151 QLDFSHNRIQSLRTKLFDNL----PALSHAHLHSNPWHCDCRASKVKALLQKVKWEKKVYCTNPV 211

Human   228 EIRTIYAAHKQAKACLISRLSC----ERAGTRFNVRGTNDDGHVANFVETEQVIYLDDCV---SS 285
            |:|     |:.......|.|:|    |.:.|...::.|     .|....::.|:::.:.|   ||
  Fly   212 ELR-----HQALDEVDDSALTCARPAEESWTGEEIKLT-----CAKNSSSKLVVWMYENVEVDSS 266

Human   286 FI---QIRGSVPLFWEQPGL----------QVGSH-RVRMSRGFEANAPAF-----DRHFRTLKD 331
            .:   :|..:|.....:..:          .:..| |:|.|:.....:|.|     |..||.
  Fly   267 SLDGYEIHDTVITVPRKTNVNFMTCTYDFDHIPHHRRLRQSQHQGNGSPQFTYKPRDNSFRE--- 328

Human   332 LYGKQIVVN--LLGSKE---GEHMLSKAFQSHLKASEHASDIHMVSFDYHQMVKGGKAEKLHSVL 391
              |.::.||  ::|:.:   ..:...|.|.|..|.....|                     ::||
  Fly   329 --GSEVKVNCEVMGNPKPTINWYHNGKRFISSRKRQLGLS---------------------NNVL 370

Human   392 KPQVQKFLDYGFFYFDGSAVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQ 456
            :  :..||:.             .||  |..| :.::....|:....|::::.  ....:.|.||
  Fly   371 R--IYPFLEE-------------DSG--RYTC-EAVNSVGKVRHAFSLDLISS--VPPNIYEGPQ 415

Human   457 LVTRFQEVFRSM---------------WSVNGDSISKIYAGTGALEGKAKAGKLKDGARSVTRTI 506
            .|:  |.:..|:               ||.:|.:|       |.::|:....  .||.......|
  Fly   416 SVS--QNLGGSVVFVCKANGNPVPDYTWSFDGSTI-------GHIKGRFMVS--DDGTELRISNI 469

Human   507 QNNFFDSSKQEAIDVLLLGNTLNSDLADKARALLTTGSLR--ASSKVLKNMCENFYKYSKPKKIR 569
            :      .|.|.....:.||.:.:..|| |:..:..|..|  |:.::.:.:
  Fly   470 E------KKDEGYYSCMAGNPVGAMSAD-AKLTVIGGETRKAAAPQIDEEL-------------- 513

Human   570 VCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGN 634
                         .|:||.|.:...:   :|.:....|..|||.:...|:             ..
  Fly   514 -------------LRAIAQKARQNVE---NAVEKTRKQLTQDKVTNTNDL-------------KR 549

Human   635 IVNASTTNQKLWAVELQKTISRDNKYVLLASEQL-VGVCLFV-FIRPQHAPFIRDVAVDTVKT-- 695
            :...||..|   ||||.|......:.|.|..|.: .|:.|.| .:.|::..:...:.|..|:.
  Fly   550 LFRFSTPKQ---AVELSKAREIYEESVRLVREHVEKGLILNVDELHPKNVSYESVLHVTHVQALM 611

Human   696 GMGGATGNKGAVAIRMLFHT-------TSLCFVCSH-FAAGQSQVKERNEDFVEIA----RKLSF 748
            |:.|.             ||       |..||  .| :.:...|...:|:....::    |:|..
  Fly   612 GLSGC-------------HTGQYKNPCTDTCF--HHRYRSFDGQCNNKNKPMTGVSLMPLRRLLK 661

Human   749 PMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLI-NQKNAGQIFR--GFLE 810
            |:....|:....:..|.......|||  |:|:.||     |:|.:.:. :.|.:..:.:  .|::
  Fly   662 PVYENGFNTPVGWEKGRLYNGYPLPN--VREVSRQ-----LVATENITPHSKLSSMVMQWGQFVD 719

Human   811 GKVTFAPTYKYDLFSEDYDTSEKC-RT-----PAWT-------DRVLWRRRKWP---FDRSA--- 856
            ..:|...|   .|....|.|...| ||     |.:.       .||.....|:|   |:|||
  Fly   720 HDLTHTVT---ALSRHSYATGAFCNRTCENLDPCFNIPLSPNDPRVKSGSAKYPCIEFERSAAVC 781

Human   857 ---------------EDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVV---ALIDI 903
                           |.::.| .||.|.|.:           ||..|::..:.|...   .::..
  Fly   782 GSGETSLVFNRVTYREQMNAL-TSFLDASNV-----------YGSNEVQAQELRDTYNNNGMLRF 834

Human   904 DI----------FEVEA--------------------------------------EERQKIYKEV 920
            ||          ||.::                                      .|..:|.|::
  Fly   835 DITSEAGKEYLPFEKDSNMDCRRNFSEENPIRCFLAGDLRANEQLALAATHTIFIREHNRIAKKL 899

Human   921 IAVQGPPDGTVL----------------------VSIKSSAQENTF------FDDALIDELLQQF 957
            .::.|..||.::                      :.....||.|.|      :|..:...:...|
  Fly   900 KSMNGNWDGEIIYHETRKIVGAMMQHITYKHWMPIIFGGQAQMNKFVGTYQGYDPDVDASVTNAF 964

Human   958 A----HFGEVI----LIRFVEDKMWVTFLEGSSALN--------VLSLNGKE-LLNRTITITLKS 1005
            |    .||..|    |.|...|.|.:.  ||..||:        ||:..|.: ||.......||.
  Fly   965 ATAAFRFGHTIINPSLFRLGNDFMPIK--EGHIALHKAFFTPELVLTQGGVDPLLRGLFASPLKH 1027

Human  1006 PDWIKTLEEEMSLEKISVTLPSSTSSTLLGEDAEVSADFDMEGDVDDYSAEVEELLPQHLQPSSS 1070
            |...:.|..|: :||            |..:..|||.|                |...::|.|..
  Fly  1028 PMPTQLLNMEL-IEK------------LFMKGHEVSLD----------------LAVMNIQRSRD 1063

Human  1071 SGLGTSPSSSPRTSPCQSPTAPEY 1094
            .||   ||.:.....|..|...::
  Fly  1064 HGL---PSYTEYRKFCNLPVPVQW 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	M13	127..776	CDD:341056	140/742 (19%)
Nep1	NP_511056.2	M13	194..847	CDD:341056	154/809 (19%)