Protein Alignment ECE1 and frma

DIOPT Version :9

• Sequence 1: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Sequence 2: NP_572226.2
• Gene: frma / 31464
• FlyBaseID: FBgn0029769
• Length: 611
• Species: Drosophila melanogaster
• Alignment Length: 749
• Identity: 161/749 - (21%)
• Similarity: 275/749 - (36%)
• Gaps: 255/749 - (34%)

Human   125 PTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHN-QAIIKHLLENSTASVSEAE----- 183
            |..|||.:|:..|||.| .|:...|.:.   :|.:..::| |..:..||:|      |.|
  Fly    23 PQADPCQNFYKVACGNW-SASHATDSYE---SFMDRLDYNYQEKLADLLDN------EREDDEPH 77

Human   184 --RKAQVYYRACMNETRIEELRAKPL-----MELIERLGGWNITGPWAKDNFQ-DTLQV-VTAHY 239
              ::.:.:|.||          .|||     :.::|.|        ...:|.| :.|.| :||.:
  Fly    78 FLQQLRNFYTAC----------RKPLSQDQVLRILEHL--------IVMENIQNEELSVGLTAAF 124

Human   240 RTSPFFSVYVSADSKNSNSNVI--QVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGG 302
            |      :.|..|..:||:..|  |:      :..|.::...|.|.:.||
  Fly   125 R------LQVLIDLNDSNTYDIWKQL------MSHRKHWDPNTTNREPLT--------------- 162

Human   303 GDEEAIRPQMQQILD-FETALANITIPQEKRRDEEL--IYHKV----------TAAELQTLAPAI 354
                      :::.| ...:|..|..|.::....||  :..|:          .:.:|.|..|..
  Fly   163 ----------REMFDKLWASLPKIPFPFKEYYWRELSELEEKIMSYGSEDDGFDSGDLVTRIPPF 217

Human   355 NWLPFLN-TIFYP--------VEINESEPIVVYDKEYLEQISTLINT------TDRC------LL 398
            ..:|:.| .|.|.        ::|..:|.|:.|....|:.::..::|      .|:|      :|
  Fly   218 WMMPWPNGNITYENLSQMAHWLDIKANEFILTYIYMRLKLVAEGVSTESWHIDRDQCAEQSRQIL 282

Human   399 NNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKAT 463
            ::...| ||.|..                          ||.|
  Fly   283 SHPAAW-LVEKNH--------------------------PRLK---------------------- 298

Human   464 FAEDSKSIATEIILEIKKAFEESL---------ST-------LKWMDEETRKSAKEKADAIYNMI 512
                .:.:..:|..|:|:.|.:.|         ||       ||.|  ..|.|...:..:..:|:
  Fly   299 ----EEPVLQDIFAELKQRFGQKLLANRNNFTRSTQHFLLGKLKRM--RLRLSILPRNSSAQSMV 357

Human   513 GYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFS---------WRVTADQLRKAPNR-DQWS 567
                     :.:::.:.|.......||.|.....|.|         |.:...: :..|:| .:..
  Fly   358 ---------RRIERHYRDVHMNASDYFGNLHIGLNHSRSHKKYAQLWAIVFGR-QLIPSRISKSD 412

Human   568 MTPPMV-------NAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQG 625
            :.|..|       :|:|...:|.::.|..:|:.||||...|..|.:..:|.::||||:|.||.:|
  Fly   413 LYPTQVRGYGTYASAFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEG 477

Human   626 REYDKDGNLRPWWKNSSVE-------AFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGL 683
            ..:...|     ..:|:|:       .|:::..|:..::           ||... |..||..||
  Fly   478 MTFSSHG-----VGSSAVDRELDRNPRFQQELGCLRRRF-----------GRKRY-EKFADASGL 525

Human   684 KAAYRAY----QNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSR 744
            :.||.||    |...|:|.:...|    :|..|.||..|||.:||.:....:|:      |...|
  Fly   526 ELAYSAYFDTAQTDHKRNRSAEEL----VTQKQQFFHNFAQFFCSDKELLQAHD------HGSDR 580

Human   745 FRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778
            .||..::::.:.|.|.|.|.| ||..  .:|.::
  Fly   581 KRVNDAVAHFEPFREAFSCGP-SPRR--RQCRLY 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	159/738 (22%)
		M13	127..776	CDD:189000	159/743 (21%)
frma	NP_572226.2	GluZincin	25..601	CDD:301352	156/732 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010