DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Plxna2 and PlexA

DIOPT Version :9

Sequence 1:XP_006497303.1 Gene:Plxna2 / 18845 MGIID:107684 Length:1901 Species:Mus musculus
Sequence 2:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster


Alignment Length:1972 Identity:812/1972 - (41%)
Similarity:1152/1972 - (58%) Gaps:216/1972 - (10%)


- Green bases have known domain annotations that are detailed below.


Mouse    47 DWTFNHLTVHRRTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKACYPPLIVQPCSEVLTLTN 111
            |...|||.|...||.|:||.:||:|:|:.:|.:....||||:.|:..|  .::..|.:.|.:.|:
  Fly    72 DTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC--SILDCPLNAVRSPTD 134

Mouse   112 NVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSE 176
            |.||:|:||.:.:||:|||||:||.|.:..|.::.|:       ||.:..         .:|.::
  Fly   135 NYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII-------EHEVPD---------AVVAND 183

Mouse   177 GEDGK----------------LFIGTAVDGKQDY---FPTLSSRKLPRDPESSAMLDYELHSDFV 222
            .....                :::|........|   .|.::||.|    |.:.|  :::.|..|
  Fly   184 ANSSTVAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKM--FQIASSAV 242

Mouse   223 SSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPDGMAINSAGDLFYTSRIVRLCKDD 287
            ::..:...::.|..::| :.|:|||:|..|.||||.|.:..     :.:....|.:::||:|::|
  Fly   243 TTGTRTFINSYARETYF-VNYVYGFSSERFSYFLTTQLKHS-----HHSSPKEYITKLVRICQED 301

Mouse   288 PKFHSYVSLPFGC---TRAGVEYRLLQAAYLAKPGEALAQAFNISSDEDVLFAIFSKGQKQYHHP 349
            ..::||..:|..|   .:.|.::.|:||.:|.||...|||:..||..:|||||:||||:.  :.|
  Fly   302 SNYYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEG--NTP 364

Mouse   350 PDDSALCAFPIRAINLQIKERLQSCYHGEGNLELNWLLGKDVQC--TKAPVPIDDNFCGLDINQP 412
            .::||||.:.:::|..:..:.::||::|.|...|:: :...:.|  ||... |.::|||||:|.|
  Fly   365 TNNSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDF-ISPSMPCVLTKLQT-IGEDFCGLDVNSP 427

Mouse   413 LGGSTPVEG--LTLYTTSRDRLTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSV 475
            |||.||:..  :.::.|   :|||||:...:||:||||||..|.|||:..:.   ..:..|..|.
  Fly   428 LGGETPITSVPVAMFNT---KLTSVAATSTSGYTVVFVGTSDGFLKKVVIES---SSIANEYASF 486

Mouse   476 FKD-GSPILRDMAFSINQLYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSR 539
            ..| ||.|.|||.|....||:||||:.:|::|.|..|..|.|||:||.:.||:||||:|.|.||.
  Fly   487 AVDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSP 551

Mouse   540 RDKCQRAWEANR----FAASISQCMSL-EVHPNSISVSDHSRLLSLVVNDAPNLSEGIACA---- 595
            |..||.  :||.    .:....:|.:: .|.|:.:..:. :|.|.|:::..|.|.|.:.||    
  Fly   552 RSNCQD--DANDPLYWVSYKTGKCTTITSVVPHQLQRTT-ARTLELIIDHLPQLKENLICAFTTE 613

Mouse   596 ----FGNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNC 656
                |.|.|:....|:     |.:|....:|.|...:..|..:|.:|:: .|...|||:|.|::|
  Fly   614 DKALFTNATKKRNGVN-----CTTPRTDMLPQIEQGKHHFTAKLSVRTR-NGPDLVSTDFTFFDC 672

Mouse   657 SAHQLCLSCVNSAFRCHWCKYRNLCTHDPT-TC--------------SFQEGRINVSEDCPQLVP 706
            |.|..|..||:|.|.|.||...:.||||.. .|              |::.|    ...||.:..
  Fly   673 STHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSG----PGFCPTINA 733

Mouse   707 T---EEILIPVGEVKPITLKARNLPQPQSGQRGYECVLSIQGAVHRVPALRFNSSSVQCQNSSYQ 768
            |   .|:|:..|..|.|.:|...:.| ...|..:.|..:|:|.|..:.| :....::.|.:..:|
  Fly   734 TGDGSEVLVAGGTSKSIKVKVHIIGQ-FIVQTRFVCQFNIEGRVTSLNA-QLLGDTIYCDSMEFQ 796

Mouse   769 YDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADHKFECGWCSGERRCT 833
            |.... .||...|||:|.|:..:|||.::.|.:|:|....:|||:||....|:.|||||....|.
  Fly   797 YTSRS-PNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCE 860

Mouse   834 LHQHCPSTSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAG 898
            :.:.|........||.:.:..|.||:|......:||.||||.:||.|:|||.::::|...|::||
  Fly   861 VEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAG 925

Mouse   899 VPCTPIPGEYIIAEQIVCEM---GHAVIGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLS 960
            :.|.|.|..||..:||||.:   |..:.  .:|.:.:.||:.:.|    |.:.|.||:|.:|..:
  Fly   926 INCMPFPQFYIDTKQIVCTVDSPGEQMY--RNGKIVVQIGDYRGE----SKEDYEFVDPKILDFN 984

Mouse   961 PIRGPESGGTMVTITGHYLGAGSSVAVYLGNQ-TCEFYGRSMNEIVCVSPPSSNGLGPVPVSVSV 1024
            |..||.||||.:.|||.:|.|||.:...:.:. .|:......::.:| ...:|.|:....:.:|.
  Fly   985 PKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAIC-RTSASPGIIEGRLKMSF 1048

Mouse  1025 DRA-RVDSSLQFEYIDDPRVQRIE---------PEWSITSGHTPLTITGFNLDVIQEPRVRVKFN 1079
            |.. |..:...|:|:.||.|:.:.         |: .|.:|...:::||.....||.|.:.|.:|
  Fly  1049 DNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPK-GIPAGGIRISVTGTQFTSIQNPNIYVVYN 1112

Mouse  1080 GKESVNVCTVVNTTTLTCLAPSLTSDYRPGLDTVERPD--EFGFLFNN---VQSLLIYNDTKFIY 1139
            |:...:.|.|.:.|.:.|.:|.:..|..  :...|||.  |:|||.:|   ||:|...::..|..
  Fly  1113 GEMYASPCRVQSDTEMECASPVVDVDSH--VIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFEL 1175

Mouse  1140 YPNPTFELLSPTGILDQK----PGSPIILKGKNL---CPPASGGAKLNYTVMIGETPCTVT-VSE 1196
            ||||.:      .|.:::    ....:.:.|:||   |..:      :..|.||...|.:| :|.
  Fly  1176 YPNPEY------FIFEERVKYFKSEYLTINGRNLDRACKES------DVEVKIGNGFCNITSLSR 1228

Mouse  1197 TQLLCEPP-------NLTGQHKVMVHVG-GMVFSPGSVSVISDSLLT---LPAIISIAAGGSLLL 1250
            .||.|.||       ::.|. :|:|.:| .:.:..|.:|..|.:::.   ...|.::.|...:||
  Fly  1229 QQLTCRPPSEATATKSMNGP-EVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIVILL 1292

Mouse  1251 IIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYL 1315
            :|.:.:|:|||:||.|:...|:.:|.|||.||.|||.|||||||||||::.:||.||...|||:|
  Fly  1293 LIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGGIPFL 1357

Mouse  1316 DYRTYAMRVLFPGIEDHPVLR----ELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQR 1376
            |||:|||::|||..|||.||:    ||       ...||.|::|.|||.||.|||.||||||..|
  Fly  1358 DYRSYAMKILFPNHEDHIVLQWERPEL-------LRKEKGLRIFGQLIMNKTFLLLFIRTLESNR 1415

Mouse  1377 SFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNW 1441
            .||||:|.|||||||..||.:|||.||:||.||.|||:|.:|.|:|||||||||||||||||:.|
  Fly  1416 YFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAW 1480

Mouse  1442 FAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIE------YKTL 1500
            |.|||:|||||||||||:||:.|:|.|::|||:||.|.||||||||:|||||.|:      |.::
  Fly  1481 FTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASI 1545

Mouse  1501 I---LNCVNPD--NENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLATHPFHP 1560
            |   :.|.|.|  ..::..:.||||:||||.|||||.|:.:|:|:|.|||||..|:||       
  Fly  1546 IQQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDL------- 1603

Mouse  1561 EWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNI-------PASA 1618
            |||.|...||:|.|||:|:|.|.:||:||||.||.|.|.:.::|||||:|.||.       ..|.
  Fly  1604 EWRTGATGRVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSH 1668

Mouse  1619 SISRTSISRYDSSFRYTGSPDSLRSRVPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEI 1683
            .....:||:|.||     ||...|:..|:.....|:|::.|||||:||...||||:|.:|:||||
  Fly  1669 KYETLNISKYTSS-----SPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEI 1728

Mouse  1684 YLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSN 1748
            ||||||||||||||||||||||:|||.||||||||||||||||||:||..|.|.|.:|.||||||
  Fly  1729 YLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSN 1793

Mouse  1749 CLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPS 1813
            .||||||||:||||.|||||||.:|.|:||||||||||||||||:|||||||||:|||||||||.
  Fly  1794 SLPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPE 1858

Mouse  1814 YKNWVERYYADIAKLPAISDQDMNAYLAEQSRLHATEFNMLSALNEIYSYVSKYSEELIGALEQD 1878
            |:.||:|||.||..:..||||||||.|||:||||.||||...||:|:|:|..||:|:|...||:|
  Fly  1859 YRKWVDRYYRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEED 1923

Mouse  1879 EQARRQRLAYKVEHLINAMSIE 1900
            |.:::||||:|:|.:.|.||.|
  Fly  1924 EFSQKQRLAFKLEQVHNIMSSE 1945

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plxna2XP_006497303.1 Sema_plexin_A2 38..552 CDD:200533 184/535 (34%)
TIG_plexin 566..654 CDD:375449 25/95 (26%)
PSI 655..702 CDD:366642 18/61 (30%)
TIG_2 708..802 CDD:375492 27/93 (29%)
PSI 806..855 CDD:366642 15/48 (31%)
IPT_plexin_repeat1 858..953 CDD:238585 35/97 (36%)
IPT_plexin_repeat2 954..1037 CDD:238584 24/84 (29%)
IPT_plexin_repeat3 1041..1141 CDD:238586 31/113 (27%)
TIG 1143..1227 CDD:366832 22/99 (22%)
Plexin_cytopl 1311..1870 CDD:369821 360/580 (62%)
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 160/484 (33%)
PSI 522..574 CDD:279745 22/53 (42%)
PSI 671..>699 CDD:279745 12/27 (44%)
PSI 830..883 CDD:279745 16/52 (31%)
IPT_plexin_repeat1 885..977 CDD:238585 35/97 (36%)
IPT_plexin_repeat2 978..1063 CDD:238584 24/85 (28%)
IPT 1078..1177 CDD:301692 29/101 (29%)
IPT_PCSR 1196..>1255 CDD:238337 18/65 (28%)
Plexin_cytopl 1353..1916 CDD:285529 361/581 (62%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 710 1.000 Domainoid score I119
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H56427
Inparanoid 1 1.050 1362 1.000 Inparanoid score I132
Isobase 1 0.950 - 0 Normalized mean entropy S4424
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000391
OrthoInspector 1 1.000 - - otm43935
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3977
SonicParanoid 1 1.000 - - X591
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.800

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