Protein Alignment Plxna1 and PlexA

DIOPT Version :10

• Sequence 1: NP_032907.1
• Gene: Plxna1 / 18844
• MGIID: 107685
• Length: 1894
• Species: Mus musculus
• Sequence 2: NP_524637.2
• Gene: PlexA / 43832
• FlyBaseID: FBgn0025741
• Length: 1945
• Species: Drosophila melanogaster
• Alignment Length: 1962
• Identity: 817/1962 - (41%)
• Similarity: 1128/1962 - (57%)
• Gaps: 202/1962 - (10%)

Mouse    44 ASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVEDNEKCYPPPSVQSCPHGL-- 106
            |.|..|.||:|...||.|:||.|||:|:||.:|.|.....|||..|:.:|    |:..||...
  Fly    70 AFDTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC----SILDCPLNAVR 130

Mouse   107 GSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSS---VREAGSMA 168
            ..|||.||:||:|.|.:||:||||..||.|....|.::..:       ||.:..   ..:|.|..
  Fly   131 SPTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII-------EHEVPDAVVANDANSST 188

Mouse   169 GVLIA-GPPGQGQAK-LFVGTPIDGKSEY---FPTLSSRRLMANEEDADMFGFVYQDEFVSSQLK 228
            ...|| |||...... ::||......|.|   .|.::||.|    |...||      :..||.:.
  Fly   189 VAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKMF------QIASSAVT 243

Mouse   229 IPSDTLSKFPAFDIY---YVYSFRSEQFVYYLTLQL-DTQLTSPDAAGEHFFTSKIVRLCVNDPK 289
            ..:.|.....|.:.|   |||.|.||:|.|:||.|| .:..:||..     :.:|:||:|..|..
  Fly   244 TGTRTFINSYARETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKE-----YITKLVRICQEDSN 303

Mouse   290 FYSYVEFPIGC---EQAGVEYRLVQDAYLSRPGQALAKQLGLAEDEEVLFTVFAQGQKNRVKPPK 351
            :|||.|.|:.|   .|.|.::.|||..:|.:|...||:.||::..::|||.||::|:.|  .|..
  Fly   304 YYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGN--TPTN 366

Mouse   352 ESALCLFTLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQ-IDDDFCGQDFNQPLGG 415
            .||||:::|::|:.|..:.|:||:.|.|...|.: ::..:.|:.:.|| |.:||||.|.|.||||
  Fly   367 NSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDF-ISPSMPCVLTKLQTIGEDFCGLDVNSPLGG 430

Mouse   416 TVTIEGTP--LFVDKEDGLTAVAAYDYQGRTVVFAGTRSGRIRKILVDLANPSGRPALAYESVVA 478
            ...|...|  :|..|   ||:|||....|.||||.||..|.::|::::    |...|..|.|...
  Fly   431 ETPITSVPVAMFNTK---LTSVAATSTSGYTVVFVGTSDGFLKKVVIE----SSSIANEYASFAV 488

Mouse   479 QEGNPILRDLVLSPNRQYLYAMTEKQVTQVPVESCVQYTSCELCLGSRDPHCGWCVLHSICSRQD 543
            ..|:.|.||:.......|:|.|::.:|::|.|..|..|.:|..|||:|||:||||.|.:.||.:.
  Fly   489 DLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRS 553

Mouse   544 AC-ERAEEPQRFAS-DLLQCVQLT-VQPRNVSVTMSQ-VPLVLQAWNVPDLSAGVNCSFEDFTET 604
            .| :.|.:|..:.| ...:|..:| |.|..:..|.:: :.|::.  ::|.|...:.|:|.  ||.
  Fly   554 NCQDDANDPLYWVSYKTGKCTTITSVVPHQLQRTTARTLELIID--HLPQLKENLICAFT--TED 614

Mouse   605 ESILEDGR-----IHCHSPSAREVAPITQGQGDQRVVKLYLKSKETGKKFASVDFVFYNCSVHQS 664
            :::..:..     ::|.:|....:..|.||: .....||.:::: .|....|.||.|::||.|.|
  Fly   615 KALFTNATKKRNGVNCTTPRTDMLPQIEQGK-HHFTAKLSVRTR-NGPDLVSTDFTFFDCSTHSS 677

Mouse   665 CLACVNGSFPCHWCKYRHVCTNNAAD-C--------------AFLEG-----RVNMSEDCPQIL- 708
            |..||:..|||.||...|.||::.|: |              ::..|     .:|.:.|..::|
  Fly   678 CTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSGPGFCPTINATGDGSEVLV 742

Mouse   709 ---PSTHIYVPVGVVKPITLAARNLPQPQSGQRGYECLFHIPGSPARVTAL--RFNSSSLQCQNS 768
               .|..|.|.|.::....:..|           :.|.|:|.|   |||:|  :....::.|.:.
  Fly   743 AGGTSKSIKVKVHIIGQFIVQTR-----------FVCQFNIEG---RVTSLNAQLLGDTIYCDSM 793

Mouse   769 SYSYEGNDVSDLPVNLSVVWNGNFVIDNPQNIQAHLYKCPALRQSCGLCLKADPRFECGWCVAER 833
            .:.|.... .:|....:|:|.|:..:|||.||...:|:|..:..|||:||....::.||||.:..
  Fly   794 EFQYTSRS-PNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTN 857

Mouse   834 RCSLRHHC--PADSPASWMHAHHGSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRL 896
            .|.:...|  ..:....|::.   |..|.:|:|....|:|||.:|||.:||.|.|||..:.|:..
  Fly   858 TCEVEEQCNKNKEGKTDWLNR---SEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYS 919

Mouse   897 GVHVGKVLCSPVESEYISAEQIVCEIGDASTLRAHDALVEVCVRDCSLHYRALSPKRFTFVTPTF 961
            ||.:..:.|.|....||..:||||.:.........:..:.|.:.|    ||..|.:.:.||.|..
  Fly   920 GVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVVQIGD----YRGESKEDYEFVDPKI 980

Mouse   962 YRVSPSRGPLSGGTWIGIEGSHLNAGSDVAVSIGGR-PCSFSWRNSREIRCLT--PPGHTPGSAP 1023
            ...:|..||.||||.|.|.|.||||||.:..||... ||.....:|.:..|.|  .||...|.
  Fly   981 LDFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSASPGIIEGR-- 1043

Mouse  1024 IVININRAQLSNPEVKYNYTEDPTILRID---------PEWSINSGGTLLTVTGTNLATVREPRI 1079
            :.::.:.......:..:.|..|||:..:.         |: .|.:||..::||||...:::.|.|
  Fly  1044 LKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPK-GIPAGGIRISVTGTQFTSIQNPNI 1107

Mouse  1080 RAKYGGIERENSCMVYNDTTMVCRAPSIDNPKRSPPELGERPD--EIGFIMDN---VRTLLVLNS 1139
            ...|.|....:.|.|.:||.|.|.:|.:|  ..|.....|||.  |.||:|||   |:.|..:::
  Fly  1108 YVVYNGEMYASPCRVQSDTEMECASPVVD--VDSHVIEAERPILLEYGFLMDNVLRVQNLSKVHN 1170

Mouse  1140 SSFLYYPDP---VLEPLSPTGLLELKPSSPLILKGRNLLPPAPGNSRLNYTVLIGSTPC-ILTVS 1200
            :.|..||:|   :.|.     .::...|..|.:.||||   .......:..|.||:..| |.::|
  Fly  1171 NHFELYPNPEYFIFEE-----RVKYFKSEYLTINGRNL---DRACKESDVEVKIGNGFCNITSLS 1227

Mouse  1201 ETQLLCEAP-------NLTGQHKVTVRAG-GFEFSPGMLQVYSDSLL----------TLPAIVGI 1247
            ..||.|..|       ::.|. :|.||.| ..|:..|:|...|.:::          .:..||
  Fly  1228 RQQLTCRPPSEATATKSMNGP-EVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIV-- 1289

Mouse  1248 GGGGGLLLLVIVAVLIAYKRKSRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIHELTSDL 1312
                 :|||:.||:|:|||:||.::.|.|:.:|.|||.||.|||.|||||||||||::.:||.||
  Fly  1290 -----ILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDL 1349

Mouse  1313 DGAGIPFLDYRTYAMRVLFPGIEDHPVLK-EMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQ 1376
            ...||||||||:|||::|||..|||.||: |.......||.|.:||||:..|.|||.||||||:.
  Fly  1350 TSGGIPFLDYRSYAMKILFPNHEDHIVLQWERPELLRKEKGLRIFGQLIMNKTFLLLFIRTLESN 1414

Mouse  1377 RSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKMLTN 1441
            |.||||:|.|||||||..||.::||.|.:||.||.|||||.:|.|:|||||||||||||||||:.
  Fly  1415 RYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSA 1479

Mouse  1442 WFTFLLYKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLT---- 1502
            ||||||||||||||||||:||:.|:|.|::|||:||.|.||||||||:|||||.||::.:.
  Fly  1480 WFTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYAS 1544

Mouse  1503 -----LNCVN----PEH-ENAPEVPVKGLNCDTVTQVKEKLLDAVYKGVPYSQRPKAGDMDLEWR 1557
                 :.|.|    |.| ||   |.||.|:|||:.|||||.|:.:|:.:|.||||:..|:|||||
  Fly  1545 IIQQPIFCNNLDMLPSHTEN---VSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWR 1606

Mouse  1558 QGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQTSAYNISNSSTFTKSLSRYE 1622
            .|...|:||.|||||:|.:::||:||||.||.|.||:.::|||||:|.||.|..|...:...:||
  Fly  1607 TGATGRVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYE 1671

Mouse  1623 SM---LRTASSPDSLRSRTPMITPDLESGTKLWHLVKNHDHLDQREGDRGSKMVSEIYLTRLLAT 1684
            ::   ..|:|||...|:.:|:.....|:|.:.|||||:||...|:||:|.:|:||||||||||||
  Fly  1672 TLNISKYTSSSPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLTRLLAT 1736

Mouse  1685 KGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQIHDSDVRHTWKSNCLPLRFWV 1749
            |||||||||||||||||||||||||||||||||||||:||..|.|.|.:|.||||||.|||||||
  Fly  1737 KGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWV 1801

Mouse  1750 NVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHKLGKDSPSNKLLYAKDIPNYKSWVERY 1814
            |:||||.|||||||::|.|:||||||||||||||||:|:|||||||:|||||||||.|:.||:||
  Fly  1802 NLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRY 1866

Mouse  1815 YADIAKMPAISDQDMSAYLAEQSRLHLSQFNSMSALHEIYSYIAKYKDEILVALEKDEQARRQRL 1879
            |.||..|..||||||:|.|||:||||.::||:..||||:|:|..||.:::.|.||:||.:::|||
  Fly  1867 YRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQKQRL 1931

Mouse  1880 RSKLEQVVDTMA 1891
            ..|||||.:.|:
  Fly  1932 AFKLEQVHNIMS 1943

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plxna1	NP_032907.1	Sema_plexin_A1	36..511	CDD:200532	173/486 (36%)
		PSI	512..554	CDD:396154	19/42 (45%)
		TIG_plexin	567..657	CDD:465588	20/95 (21%)
		PSI	658..705	CDD:396154	20/66 (30%)
		TIG_2	713..805	CDD:465619	23/93 (25%)
		PSI	809..855	CDD:396154	12/47 (26%)
		IPT_plexin_repeat1	862..958	CDD:238585	32/95 (34%)
		IPT_plexin_repeat2	959..1044	CDD:238584	28/87 (32%)
		IPT_plexin_repeat3	1046..1146	CDD:238586	35/113 (31%)
		TIG	1148..1232	CDD:460355	25/95 (26%)
		Plexin_cytopl	1316..1859	CDD:462434	357/560 (64%)
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	171/480 (36%)
		PSI	522..574	CDD:396154	20/51 (39%)
		TIG_plexin	580..670	CDD:465588	20/95 (21%)
		PSI	671..>702	CDD:396154	15/30 (50%)
		TIG_2	738..829	CDD:465619	25/105 (24%)
		PSI	830..883	CDD:396154	14/55 (25%)
		IPT_plexin_repeat1	885..977	CDD:238585	32/95 (34%)
		IPT_plexin_repeat2	978..1063	CDD:238584	27/86 (31%)
		IPT	1078..1177	CDD:472823	33/101 (33%)
		TIG	<1196..>1246	CDD:460355	15/52 (29%)
		Plexin_cytopl	1353..1911	CDD:462434	357/560 (64%)