DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plk1 and Ire1

DIOPT Version :10

Sequence 1:NP_035251.3 Gene:Plk1 / 18817 MGIID:97621 Length:603 Species:Mus musculus
Sequence 2:NP_001097839.1 Gene:Ire1 / 42358 FlyBaseID:FBgn0261984 Length:1074 Species:Drosophila melanogaster


Alignment Length:513 Identity:121/513 - (23%)
Similarity:196/513 - (38%) Gaps:154/513 - (30%)


- Green bases have known domain annotations that are detailed below.


Mouse     2 NAAAKAGKLARAPAD-LGKGGVPGDAVPGAPVAAPLAKEIPEVLVDPRSRRQYVRGRFLGKGGFA 65
            |...:.||::.:..: ||||                                 ..|.|:.||.|.
  Fly   538 NGQVRVGKISFSTNEVLGKG---------------------------------CEGTFVFKGTFE 569

Mouse    66 KCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHR-SLAHQHVVGFHDFFEDSDFVFVV 129
            :.|         |...:::|:....       ...|:::.| |.||::||.:....:|..|.::.
  Fly   570 ERF---------VAVKRLLPECFTF-------ADREVALLRESDAHENVVRYFCTEQDRQFRYIA 618

Mouse   130 LELCRR---------RSL-LELHKRRKALTEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFL 184
            :|||..         ||| |:.|        .:....|.|...|..:||...::|||:|..|:.:
  Fly   619 VELCAATLQDYTEGDRSLELQNH--------IDVWQVLSQAASGLSHLHSLDIVHRDIKPQNVLI 675

Mouse   185 N-----EDLEVKIGDFGLATKVEY---EGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIM 241
            :     ..:.|.|.||||..|:.:   ...|:..:.||..:||||::..:..:..||::|:||:.
  Fly   676 SLPDAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTDGWIAPEMMRSQRTTTAVDIFSLGCVY 740

Mouse   242 YTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINP----------VAASLIQKMLQTDPTARPTI 296
            |.:|.|........||. ...|..:||::.| :.|          :|..||..|:..||.:||  
  Fly   741 YYVLSGGHHAFGDNLKR-QANILSHEYNLAK-LRPEDDSEDSRIILAEQLISDMIHKDPQSRP-- 801

Mouse   297 HELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSL----DPSSR--------KPLKVLNKGVEN 349
                          |||    |:...|.|...|..|    |.|.|        :|||.|.|....
  Fly   802 --------------PAR----CIGNHPLFWDEPKMLSFLQDVSDRVEKLQFHAEPLKSLEKNGRI 848

Mouse   350 PLPDRPREKEEPVV----RETNEAIECHLSDLLQQLTS----VNASKPSERGLVRQEEAEDPACI 406
            .:.|......:|::    |:....:...:.|||:.|.:    .:...|:.:.::        .||
  Fly   849 VVLDDWNVHLDPMITDDLRKYRGYMGASVRDLLRALRNKKHHYHELTPAAQKML--------GCI 905

Mouse   407 PIFWVSKWVD-----YSDKYGLGYQLCDN--------SVGVLFNDSTRLILYNDGDSL 451
            |..:.:.|||     .|..|. .:.:|.|        |.|.||   ||...::..|:|
  Fly   906 PHEFTNYWVDRFPQLISHAYH-AFSICSNEPIFKPYYSAGYLF---TRPWYFDADDAL 959

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plk1NP_035251.3 STKc_PLK1 45..309 CDD:271089 72/292 (25%)
Activation loop. /evidence=ECO:0000250 194..221 10/29 (34%)
D-box that targets the protein for proteasomal degradation in anaphase. /evidence=ECO:0000250 337..340 1/10 (10%)
POLO_box_1 407..494 CDD:240561 16/58 (28%)
Linker. /evidence=ECO:0000250 493..507
POLO_box_2 509..590 CDD:240560
Important for interaction with phosphorylated proteins. /evidence=ECO:0000250 538..540
Ire1NP_001097839.1 Luminal_IRE1 53..321 CDD:188875
STKc_IRE1 545..813 CDD:270884 82/346 (24%)
RNase_Ire1 817..941 CDD:199217 27/132 (20%)
Blue background indicates that the domain is not in the aligned region.

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