DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plk1 and SAK

DIOPT Version :10

Sequence 1:NP_035251.3 Gene:Plk1 / 18817 MGIID:97621 Length:603 Species:Mus musculus
Sequence 2:NP_649324.1 Gene:SAK / 40384 FlyBaseID:FBgn0026371 Length:769 Species:Drosophila melanogaster


Alignment Length:596 Identity:172/596 - (28%)
Similarity:266/596 - (44%) Gaps:102/596 - (17%)


- Green bases have known domain annotations that are detailed below.


Mouse    59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQHVVGFHDFFEDS 123
            |||||||..::.....|.:..|.|::.|.|:.......::..|:.||..|.|..|:..:.||:|:
  Fly    20 LGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVLQLYTFFQDA 84

Mouse   124 DFVFVVLELCRRRSLLELHKR----RKALTEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFL 184
            ::|::||||....   |||:.    .:..||.||...|:|:|.|..|||.:.::|||:.|.||.|
  Fly    85 NYVYLVLELAHNG---ELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLLL 146

Mouse   185 NEDLEVKIGDFGLATKVEYEGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKP 249
            :.::.|||.||||||:::...||..|:|||||||:|||:|:..|....||||:||::||||||:|
  Fly   147 SREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYTLLVGRP 211

Mouse   250 PFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIHELLNDEFF----TSGY- 309
            ||||..::.|..::..:||.:|.|::..|..||.|:|:..|..|.|:..:|...|.    ..|: 
  Fly   212 PFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKCSNGGHS 276

Mouse   310 IPARLPITCLTIPPRFSIAPSSLD--------PSSRKPLKVLNKGVENPLPDR--PREKEEPVVR 364
            .|..|.:        ||.:..|.|        ..||...::  :.|||..|.:  |:.:||  .:
  Fly   277 APGALNV--------FSQSMESGDSGIITFASSDSRNSQQI--RSVENSGPQQVLPQIREE--FK 329

Mouse   365 ETNEAIECHLSDLLQQLTSVNASKPSERGLVRQE----EA------------EDPACIPIFWVSK 413
            :.:..:....:.|..| .|...::|:..|..:..    ||            ||...:|.....:
  Fly   330 QVHHKLPYEQTGLFGQ-ASTGLAEPNWPGAAKSSAFCMEAGNVPNSKQASLKEDRISVPPLNTKR 393

Mouse   414 WVD--YSDKYGLGYQLCDNSVGVLF------------NDSTRLILYNDGDSLQYIERDGTESYLT 464
            .:.  |..|..:...|.:..|.:.|            ||..|  :.:||..:...:.|.... |.
  Fly   394 LLPTRYKTKNAIMSILRNGEVVLEFLKFRPTYNEDRINDICR--ISDDGQRIIIYQPDPGRG-LP 455

Mouse   465 VSSHPNSLM--KKITLLNYFRNYMSEHLLK--AGANITPREGDELARLPYLRTWFRTRSAIILHL 525
            |...|..|.  ....:.|| .|..|:|..|  .||...   |...::.|.: |:|.|.....|..
  Fly   456 VREQPPDLQIPSGDCVYNY-DNLPSKHWKKYIYGARFV---GLVKSKTPKV-TYFSTLGKCQLME 515

Mouse   526 SNGTVQINFFQDHTKLILCPLMAAVTYINEKRDFQTYRLSLLEEYGC----------------CK 574
            :....:|.|:.. .||:..|......|....        .||.:|.|                |.
  Fly   516 TMTDFEIRFYSG-AKLLKTPSEGLKVYDRNG--------MLLSDYSCSESRSLIEHGNECFTHCV 571

Mouse   575 ELASRLRYART 585
            .:::.|..|:|
  Fly   572 NISNALEVAQT 582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plk1NP_035251.3 STKc_PLK1 45..309 CDD:271089 103/257 (40%)
Activation loop. /evidence=ECO:0000250 194..221 16/26 (62%)
D-box that targets the protein for proteasomal degradation in anaphase. /evidence=ECO:0000250 337..340 1/2 (50%)
POLO_box_1 407..494 CDD:240561 22/104 (21%)
Linker. /evidence=ECO:0000250 493..507 3/13 (23%)
POLO_box_2 509..590 CDD:240560 19/93 (20%)
Important for interaction with phosphorylated proteins. /evidence=ECO:0000250 538..540 0/1 (0%)
SAKNP_649324.1 STKc_PLK4 12..267 CDD:271088 102/249 (41%)
POLO_box_Plk4_1 382..497 CDD:240557 26/121 (21%)
POLO_box_Plk4_2 498..596 CDD:240558 19/95 (20%)
POLO_box_Plk4_3 657..738 CDD:240559
Blue background indicates that the domain is not in the aligned region.

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