Protein Alignment Pld1 and Pld

DIOPT Version :9

• Sequence 1: NP_001355596.1
• Gene: Pld1 / 18805
• MGIID: 109585
• Length: 1074
• Species: Mus musculus
• Sequence 2: NP_001137610.1
• Gene: Pld / 35554
• FlyBaseID: FBgn0286511
• Length: 1364
• Species: Drosophila melanogaster
• Alignment Length: 1230
• Identity: 456/1230 - (37%)
• Similarity: 645/1230 - (52%)
• Gaps: 202/1230 - (16%)

Mouse    13 TLQKIAADMSNLIENLDTRELHFEGEEVEYDASPGDPKAQEGCIPFSSIYN-TQGFKEPNIQTYL 76
            |:.....|...|:|..:|     :.:|.|:|....:.......|||:|||. :..|.....:.::
  Fly   169 TILSNVGDKPVLVERKET-----DDDEEEFDDEENNSVVLRHEIPFTSIYGPSVKFNSFQRKVFI 228

Mouse    77 SGCPIKAQVLEVERFTSTSRVPSINLYTIELTHGEFTWQVKRKFKHFQEFHRELLKYKAFIRIPI 141
            .|..|..::::.|| :.|:.:.:.||||||||||.|.|.:||::|||...|::|..::..:.||.
  Fly   229 PGREIHVRIVDTER-SVTTHLLNPNLYTIELTHGPFKWTIKRRYKHFNSLHQQLSFFRTSLNIPF 292

Mouse   142 PTKRHTFRRQNVKEEPREM---------------------------------------------- 160
            |::.|..:|..:|...|||
  Fly   293 PSRSHKEKRTTLKATAREMADESTLKDLPSHTKVKQTSTPLRAEGRSSKIAGSNANNAMAMISPN 357

Mouse   161 -------------------------PSLPRSSENAIQEEQFFGRRKQLEDYLTKILKMPMYRNYH 200
                                     |..|...|:.:..|....|.|||||||..:|.:.:||::|
  Fly   358 HSSILAGLTPRRIQKKRKKKKKRKLPRFPNRPESLVTVENLSVRIKQLEDYLYNLLNISLYRSHH 422

Mouse   201 ATTEFLDVSQLSFIHDLGPKGLEGMIMKRSGGHRIPG-----------VNCCGHGR------ACY 248
            .|..|::||.:||:..:|.||.||:|:||:|..| ||           .|||....      .|.
  Fly   423 ETLNFVEVSNVSFVPGMGIKGKEGVILKRTGSTR-PGQAGCNFFGCFQKNCCVRCNYFCSDVVCG 486

Mouse   249 RWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFRVKVGRKETETKYGLRIDNLSRTLILKCNSY 313
            .|..||..||::...|::|..|:|..|:|.|:.|.|..|..:|..:.||::...:|.::|||.:.
  Fly   487 TWRNRWFFVKETCFGYIRPTDGSIRAVILFDQGFDVSTGIYQTGMRKGLQVLTNNRHIVLKCWTR 551

Mouse   314 RHARWWGGAIEEFIRKHGADFLKDHRFGSYAALHENTLAKWYVNAKGYFEDIANAMEEASEEIFI 378
            |..:.|...::.....:..||...:...|:|.:..||.|.|||:...|...:|:.:|.|.|||:|
  Fly   552 RKCKEWMQYLKNTANSYARDFTLPNPHMSFAPMRANTHATWYVDGAQYMSAVADGLEAALEEIYI 616

Mouse   379 TDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYSKRTLMRLHP 443
            .||||||||::|||.::|:.||||.||.|||:||||:|::||||||:||||||.|||.||.: |.
  Fly   617 ADWWLSPEIYMKRPALDGDYWRLDKILLRKAEQGVRVFVLLYKEVEMALGINSYYSKSTLAK-HE 680

Mouse   444 NIKVMRHPDHVSSSVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGLS 508
            ||||||||||....:.|||||||:|:|||:.||:|||||.||||||:.|||||:||:.  ||..|
  Fly   681 NIKVMRHPDHARGGILLWAHHEKIVVIDQTYAFMGGIDLCYGRWDDHHHRLTDLGSIS--TSSFS 743

Mouse   509 LGSLTAASV----ESMESL--SLKDKHEFH-----KKEPISKIVDE--TDMKLK----------- 549
            ..:....|:    :..:|.  |.|.....|     |:.|.|...||  |.::||
  Fly   744 GSTRRTPSLYFTKDDTDSAFGSRKSSRNAHYDTSAKERPPSPPPDEPNTSIELKTLKPGDRLLIP 808

Mouse   550 --------------GIG-KSRKFSKFSLYR---------------QLHRHHLHNADSISSIDSTS 584
                          ||. :..|.:...:.|               ::.:..:|...:..:.:.::
  Fly   809 STLVSSPGETPAESGIALEGMKLNTPEMERKNVLDRLKNNAMKGARMGKDFMHRLTATETEEKSA 873

Mouse   585 SYFSHCRSHQNLIHGLKPHLKLFHPSSESEQGLTRHSTDTGSIRSVQTGVGELHGETRFWHGKDY 649
            ..:: ..|.:...|    .:.|...|...|..:|..||..         :.|..|:.::|.||||
  Fly   874 EVYT-IESEEATDH----EVNLNMASGGQEVAITTSSTQI---------LSEFCGQAKYWFGKDY 924

Mouse   650 CNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIGSVVHGKAARDVARHFIQRWNFTKIMKPKYRSL 714
            .||:.|||:.|:.||.|.|||.:||||||||:|..|.|.:|||||||||||||..|:.|.: .:.
  Fly   925 SNFILKDWMNLNSPFVDIIDRTTTPRMPWHDVGLCVVGTSARDVARHFIQRWNAMKLEKLR-DNT 988

Mouse   715 SYPFLLPKSQATAHELR----YQVPGAVPAKVQLLRSAADWSAGIKHH---EESIHAAYIHVIEN 772
            .:|:|:|||.   |::|    .|.........|||||.:.||.|....   |:|||.|||..|..
  Fly   989 RFPYLMPKSY---HQVRLNPNIQQNRQQRVTCQLLRSVSAWSCGFIEADLVEQSIHDAYIQTITK 1050

Mouse   773 SKHYIYIENQFFISC-------ADDKVVFNKVGDAIAQRILKAHREGQRYRVYIVIPLLPGFEGD 830
            ::||:||||||||:.       .....|.|::|:.:.:||::||:|.:.:|||:::|||||||||
  Fly  1051 AQHYVYIENQFFITMQLGMGVPGAYNNVRNQIGETLFKRIVRAHKERKPFRVYVIMPLLPGFEGD 1115

Mouse   831 ISTGGGNALQAIMHFNYRTMCRGESSILEQLK------PELGNKWINYISFCGLRTHAELEGNLV 889
            :....|.|::||.|:||.::.||.:|||.:|:      ||      |||||..||.|:.|....:
  Fly  1116 VGGSTGIAVRAITHWNYASISRGRTSILTRLQEAGIANPE------NYISFHSLRNHSFLNNTPI 1174

Mouse   890 TELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARD 954
            |||||||||||||||..||.||||||||||:||||||:|.|:.|.|.....|:||:|.:|.||..
  Fly  1175 TELIYVHSKLLIADDRVVICGSANINDRSMIGKRDSEIAAILMDEEFEDGRMNGKKYPSGVFAGR 1239

Mouse   955 LRLECFRLVLGYLSDPSE-----DLQDPVSDKFFKEIWVSTAARNATIYDKVFRCLPNDEVHNLI 1014
            ||...|:..||.|.....     |:.|||.:||:...|...:.:|..|||:||:|:|.|.|....
  Fly  1240 LRKYLFKEHLGLLESEGSSRSDLDINDPVCEKFWHGTWRRISMQNTEIYDEVFKCIPTDFVKTFA 1304

Mouse  1015 QLRDFINKPILAKEDRLRAEEELRKIRGFLVQFPLYFLSEENLLPSVGTKEAIVPMEVWT 1074
            .||.:..:|.|||.....|......|:|:||..||.||::|.|.|...:||.::|..|||
  Fly  1305 SLRKYQEEPPLAKTAPDLAANRANDIQGYLVDLPLEFLNKEVLTPPGTSKEGLIPTSVWT 1364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pld1	NP_001355596.1	PLN02866	82..1059	CDD:215467	432/1143 (38%)
		Catalytic	463..928		213/538 (40%)
Pld	NP_001137610.1	PX_PLD	230..431	CDD:132805	51/201 (25%)
		PH_PLD	419..564	CDD:269956	48/145 (33%)
		PLDc_vPLD1_2_yPLD_like_1	590..734	CDD:197236	94/144 (65%)
		PLDc_vPLD1_2_yPLD_like_2	1032..1220	CDD:197239	98/193 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842747
Domainoid	1	1.000	175	1.000	Domainoid score	I3636
eggNOG	1	0.900	-	-		E1_COG1502
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	776	1.000	Inparanoid score	I529
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58673
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001475
OrthoInspector	1	1.000	-	-		otm43397
orthoMCL	1	0.900	-	-		OOG6_100567
Panther	1	1.100	-	-	LDO	PTHR18896
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2299
SonicParanoid	1	1.000	-	-		X1041
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790