DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lmd-5 and Cht10

DIOPT Version :9

Sequence 1:	NP_001309512.1	Gene:	lmd-5 / 187942	WormBaseID:	WBGene00020141	Length:	1518	Species:	Caenorhabditis elegans
Sequence 2:	NP_001036422.1	Gene:	Cht10 / 3355116	FlyBaseID:	FBgn0250907	Length:	2286	Species:	Drosophila melanogaster

Alignment Length:	1487	Identity:	293/1487 - (19%)
Similarity:	494/1487 - (33%)	Gaps:	516/1487 - (34%)

- Green bases have known domain annotations that are detailed below.

Worm   254 VDDTICVSKKFSCQHRIEILNGDTCGFLENAFQTNNTEMEIANEGVKCDNLPIGRMMCVWSADDR 318
            |..:.|.|.:|       ..:.:.|....:.|.....:.:....|:..:|...|   |.|.:..:
  Fly   687 VQPSNCKSGEF-------FADSNNCNAYYHCFFAGELQQQFCPSGLHWNNEAKG---CDWPSSAQ 741

Worm   319 ---KLPNMTCTEWKTITDDSSDCYSEAKKLSITIDLFKFLNPRVNCVNRQKILRGSRICIKSQST 380
               ||.....|.:......|       ||...|      |.|     |::.....:...:.|.|:
  Fly   742 CSLKLDQHLSTSYPNPIQTS-------KKPETT------LKP-----NKKPSEISTHHQVNSTSS 788

Worm   381 KP---------CT------------YFQMVNQF---QSCEDIMQRSQISMRKLLELNPTFRCDKM 421
            :|         ||            |:..||:.   ..|...:....|  :||.:.....:|...
  Fly   789 RPQYMRPTILECTEGDYYPHRNCRKYYICVNKALVPSECGGDLHWDGI--KKLCDWPENVQCVTS 851

Worm   422 AKYEQICLGIGPFRQEQCISSRRVTPENDNCDKIM-----------RPTGL-------------- 461
            .||.:|........::.|...:|| |...||.|.:           .|.||
  Fly   852 KKYLKIIKSSSANEEDPCKGEKRV-PYPGNCSKYLFCLWNRLQASDCPPGLHYNERIGNCDWPAA 915

Worm   462 ---------SREQIEA---------------LNP----------------EVNCW-ESFEW---- 481
                     |.|:.|.               |.|                :|.|: .::.|
  Fly   916 AKCNPKGSESSEEAELNAMPKPPTPQTPSSHLRPTYPTEKPVPKPRDSHYKVICYFTNWAWYRKG 980

Worm   482 ---------GTLICTASL------------------GVDTKNAQNLVVTSLKD----VSPELARK 515
                     .|.:||..:                  ..|.:|.....|||||.    ||..|...
  Fly   981 IGRFTPDDINTELCTHVIYGFAVLDYSELVLRTHDSWADVENNFYTRVTSLKSKGIKVSLALGGW 1045

Worm   516 YDIYTSNPTEAAENDMNEQLVRDLQNPNVNSKLKELYKSDERIRKI------LDSQHPLPRQSYC 574
            .|         ::.|...:|||   :|...|:.  :..:.|.|.|.      ||.::|:..|:.|
  Fly  1046 ND---------SQGDKYSRLVR---SPMARSRF--VRHALEFIEKYGFEGLDLDWEYPVCWQTEC 1096

Worm   575 DE------------IQKTTMGYNIKSCYCGNEELLIYCQVLVS-NFMTEGEDFNEESQNVTTLRA 626
            ::            :|:.:..:..:.       |::...|..| ..:..|.|..:.|:....:..
  Fly  1097 NKGSTEEKDGFTAWVQELSEAFRPRG-------LMLSTAVSPSRKIIDAGYDIPQLSRYFDWIAV 1154

Worm   627 --------FRSKRG-VGCNFNHPFSGEDSLEYFTKIHGGCFGGGCSFPVGFLEISIDADICAPLI 682
                    :..|.| |...::||   :|..|||.                              :
  Fly  1155 MTYDFHGHWDKKTGHVAPLYHHP---DDDFEYFN------------------------------V 1186

Worm   683 SFGIDSLSYCTKDGNDCNQVDKGDAPGLKFLTERKVGGKFSLCAIGSKLVKILSKGGVSLCWDIV 747
            ::   |::|..:.|          ||..|.:.                        |:.|
  Fly  1187 NY---SINYWMEKG----------APSQKLVM------------------------GIPL----- 1209

Worm   748 ATDYYG--FVGKLSISSDLNLIA-FDLEGGAVMKVHG-LAFPEICDRVDFECEDYCIWKNKNWEN 808
                ||  |..:.:.||.||..| ...|.|...:..| ||:.|||:||:.:.     |:..:.|.
  Fly  1210 ----YGQSFTLENTNSSGLNAKAPAPGEAGEFTRAAGFLAYYEICERVNRQG-----WQVVHDEF 1265

Worm   809 GKAYGFFNFRLLKVFGFEGIKIFSETFDAPKRVGCDAGKEAAVVIRNER-----TCRDDQDRDVE 868
            |:         :..:.::|.:..|  :|:|     |..::.::::|:.:     ....|.| |.:
  Fly  1266 GR---------MGPYAYKGTQWVS--YDSP-----DMVRKKSLLVRSLKLGGGMVWALDLD-DFK 1313

Worm   869 RRCWSGDDMMNWE----------FLQLEWGFAFKPKPFGGTLFVCEFIDRHEQKIGFDVYGGKSK 923
            .||.:|...:..|          .:::.......|..:.|.          |::|        .:
  Fly  1314 NRCGNGVHPLLTEIHNVLKDPPSLMEIPGPIETTPTEYPGM----------EEEI--------HE 1360

Worm   924 NKGKNTFYYAVRNDGIYFGTEKYKEDQLMGSWDNVCEEDKESEDDSSTADSAEPTGSSSVPAASC 988
            :.|:              |.|....:.:|.:.:|      |.|:.....|........::.|...
  Fly  1361 SNGE--------------GPEVQPIEAVMQTCEN------EGEEHEGILDPNHVLEEENIEATEM 1405

Worm   989 GK--RIVGYYTGW------GEREITENQLKKL-THVIFAFVAMYADGSVKFGPVSADDPGPQAGK 1044
            ..  :|:.|:|.|      |.:.:.|:....| ||:|:.|..:..|...    :...|.......
  Fly  1406 ATEFKIICYFTNWAWYRQGGGKFLPEDIDSDLCTHIIYGFAVLSRDNLT----IQPHDSWADLDN 1466

Worm  1045 KAERRFVDMKKKARAVNSGVRVLFAVGGWDNS--QYFSSVAADSGKRRNFVDSVASFIEHHKIDG 1107
            |...|.|..:||      |.:|..|:|||::|  ..:|.:..:...|..|:.:|..|||.:..||
  Fly  1467 KFYERIVAYRKK------GAKVTVAIGGWNDSAGDKYSRLVRNPEARSRFIRNVLDFIEEYNFDG 1525

Worm  1108 VDLDWEYP-----EMKGGDKQNHVTLIRELRERFNGMASRNNRKDPYLITLASAAGEWNLREGYD 1167
            :|||||||     :.|.|..:..:.....:||.|.....|.     .:::.|.:..:..:..||:
  Fly  1526 LDLDWEYPVCWQVDCKKGTAEEKIGFSALVRELFYAFQPRG-----LILSAAVSPNKKVIDAGYE 1585

Worm  1168 LKGILNYADFINVMTYDYYGAWESKWGAYTGTPAPLYFGSLKGFSGKLNADFSMKFYACNTKKPS 1232
            :..:.:|..:|:||.|||:|.|:.|    ||..||:|  |....:...||:|||.::........
  Fly  1586 VAELSHYFSWISVMAYDYHGQWDKK----TGHVAPMY--SHPEGTANFNANFSMNYWISMGADRR 1644

Worm  1233 QLTMGVPFYGRYWKNVLEPIDASDNMWRTAAPQNGKYEGG-----------YVGWRNLEKEGWNK 1286
            :|.||:|.||:.:..      |.....:..||..|..|.|           |.....:....||.
  Fly  1645 KLVMGIPLYGQSFSL------AETTKHQLNAPTYGGGEAGEATRARGFLAYYEICLKIRHHRWNV 1703

Worm  1287 GSATWHKKTKTPYIMNNGARMFLGFENERSLKEKMDYATNRNLGGLMIWALDLDDDADTLLNLVS 1351
            ...|  |....|:..:..  .::.|::...::.|.:|.....|||.|||||||||
  Fly  1704 VRDT--KGRIGPFAYHGD--QWVSFDDVPMIRHKSEYIKAMGLGGAMIWALDLDD---------- 1754

Worm  1352 SAGLCSGGSGDKITYKCVPIDDVRWWTPENSDENRQGQCGKSAPLINGFYPVCDPDDPGFSCCGA 1416
            ...:|                                :| :|.||:.....|.    .||
  Fly  1755 FKNVC--------------------------------EC-ESYPLLKAINRVL----RGF----- 1777

Worm  1417 AGYCGSEEEYCECKGCVNYRKDPDLIVKEPVKPSREIQWYTQDAPDGKRGRCGKDIE-------- 1473
                |..:..|..:...:..| |:  :|.|.:|       |.:||.      |.:::
  Fly  1778 ----GGPQPKCLLENPKSTMK-PN--IKPPFRP-------TINAPS------GPNLDSPTQNVSL 1822

Worm  1474 -----KINGKMPICNPDDDTK-YCCSNGGY----CGIGDEYCK--CDGCVNYRTTNG 1518
                 |.:.|..:.:..|.|| |.|.:|.|    |.:|.::.|  ||...|.:::.|
  Fly  1823 NVLSIKCHSKNYLAHEWDCTKYYICEHGTYVERSCPLGLQWNKTYCDWPTNVQSSLG 1879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lmd-5	NP_001309512.1	LysM	22..65	CDD:197609
		LysM	77..120	CDD:197609
		LysM	151..194	CDD:197609
		LysM	220..260	CDD:197609	1/5 (20%)
		LysM	275..312	CDD:197609	5/36 (14%)
		LysM	386..429	CDD:197609	10/45 (22%)
		Self-incomp_S1	851..944	CDD:283566	14/107 (13%)
		Glyco_18	991..1336	CDD:214753	97/369 (26%)
		GH18_chitinase-like	992..1336	CDD:299167	97/368 (26%)
		ChtBD1_GH18_2	1388..1435	CDD:211315	9/46 (20%)
		ChtBD1_GH18_2	1462..1513	CDD:211315	15/70 (21%)
Cht10	NP_001036422.1	Glyco_18	220..565	CDD:214753
		GH18_chitolectin_chitotriosidase	221..586	CDD:119351
		ChtBD2	697..737	CDD:214696	7/49 (14%)
		CBM_14	801..848	CDD:279884	8/48 (17%)
		CBM_14	875..918	CDD:279884	8/43 (19%)
		Glyco_18	966..1310	CDD:214753	83/464 (18%)
		GH18_chitolectin_chitotriosidase	967..1331	CDD:119351	89/485 (18%)
		Glyco_18	1410..1753	CDD:214753	101/373 (27%)
		GH18_chitolectin_chitotriosidase	1411..1774	CDD:119351	109/436 (25%)
		ChtBD2	1834..1871	CDD:214696	12/36 (33%)
		Glyco_18	1909..2253	CDD:214753
		GH18_chitolectin_chitotriosidase	1910..2274	CDD:119351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164209
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4747
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740