DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment R151.1 and btl

DIOPT Version :9

Sequence 1:	NP_001299880.1	Gene:	R151.1 / 187907	WormBaseID:	WBGene00020106	Length:	696	Species:	Caenorhabditis elegans
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	451	Identity:	142/451 - (31%)
Similarity:	229/451 - (50%)	Gaps:	89/451 - (19%)

- Green bases have known domain annotations that are detailed below.

Worm   311 SSSEIPKTTPIPEISGSAITKT----TMLMESSILVIFLIVVACMSPICTMIVLLCLR--RRKKE 369
            ||..:...:|:|.:...|:...    ..|...:|:.:||:..|        .:...||  ||:|.
  Fly   577 SSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSA--------FITFMLRRLRREKL 633

Worm   370 IKKRHHFLHRRSLSCSRHSIIETNILYRPPNEVNGG---------------------TTG----- 408
            :|.|...:|:.:         :..|:|||..|...|                     |||
  Fly   634 LKLRIETVHQWT---------KKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTD 689

Worm   409 --------------EWLIRGQDIVVGAVIGEGAFGQVF----KGILRGPNGQVIPVAVKQLKANA 455
                          .|.|..|.:.:|:::||||||:|.    :|:.|.|......||||.:|...
  Fly   690 PAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEH 754

Worm   456 IDEEREEFVREIQMMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMR-----KEK 515
            .|.:....|||:::|:.:|:|.||:.:.|.|.......:|:||.|:|:||.:|:..|     :..
  Fly   755 TDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRS 819

Worm   516 DSDSAIDSKEFLS-----------FTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFG 569
            |||..:|.|..:|           |..|||.||.:|.|...|||||||||:||..|.|:||:|||
  Fly   820 DSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFG 884

Worm   570 MSR----PGVYIKMSKGVIPLRWLSPEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNV-ADK 629
            ::|    ...|.|.:.|.:|::|::||::::..|.::||||::|||||||.|.|..||.:: :.:
  Fly   885 LARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAE 949

Worm   630 DILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKIEQIANVDADAPPSD 690
            ::.:.|..|.|:|:|||||.::|::|:.||:.::..||:|..::...:.|.. .|.:.|:|
  Fly   950 ELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQ-QASSNPND 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
R151.1	NP_001299880.1	PTKc	422..677	CDD:270623	107/279 (38%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652
		Ig	258..340	CDD:143165
		I-set	394..479	CDD:254352
		IGc2	408..469	CDD:197706
		IG_like	492..583	CDD:214653	2/5 (40%)
		Ig	507..583	CDD:299845	2/5 (40%)
		PKc_like	700..1000	CDD:304357	111/299 (37%)
		TyrKc	712..996	CDD:197581	108/283 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810